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Histological and neurophysiological changes induced by carrageenan in skeletal muscle of cat and rat

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Abstract

Infiltration of the rat gastrocnemius-soleus (GS) muscle with carrageenan induced a myositis which was characterized histologically by an accumulation of polymorphonuclear leukocytes around capillaries and small arterioles. In chloralose-anaesthetized cats having an inflamed GS-muscle, the discharge behaviour of single muscle receptors with group III and IV afferent fibres was recorded. Concerning background activity, only group III receptors showed a significant increase, whereas a significant lowering in mechanical threshold was present only among group IV receptors. Both high- and low-threshold mechanosensitive receptors showed signs of a sensitization. In contrast to group IV receptors in the cat, rat group IV receptors showed a significantly higher level of background activity in inflamed muscle but no increased responsiveness to mechanical stimuli. Acetylsalicylic acid (ASA) influenced only some of the receptors in the inflamed tissue. Leukotriene D4 did not act as a sensitizing substance but depressed the activity of group IV muscle receptors.

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References

  1. P. Berberich, U. Hoheisel and S. Mense,Effects of a carrageenan-induced myositis on the discharge properties of group III and IV muscle receptors in the cat. J. Neurophysiol.59, 1395–1409 (1988).

    PubMed  Google Scholar 

  2. R. Devere and W. G. Bradley,Polymyositis: its presentation, morbidity and mortality. Brain98, 637–666 (1975).

    PubMed  Google Scholar 

  3. M. Di Rosa, J. P. Giroud and D. A. Willoughby,Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine. J. Path.104, 15–29 (1971).

    PubMed  Google Scholar 

  4. H. Z. Movat,Mediators of the vascular phenomena of acute inflammation. In: (Ed. H. Z. Movat)The Inflammatory Reaction. pp. 77–109, Elsevier, Amsterdam 1985.

    Google Scholar 

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Authors and Affiliations

  1. Anatomisches Institut III, Universität Heidelberg, Im Neuenheimer Feld 307, D-6900, Heidelberg, FRG

    B. Diehl, U. Hoheisel & S. Mense

Authors
  1. B. Diehl
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  2. U. Hoheisel
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  3. S. Mense
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Diehl, B., Hoheisel, U. & Mense, S. Histological and neurophysiological changes induced by carrageenan in skeletal muscle of cat and rat. Agents and Actions 25, 210–213 (1988). https://doi.org/10.1007/BF01965013

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  • DOI: https://doi.org/10.1007/BF01965013

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