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A new method of measuring functional recovery after crushing the peripheral nerves in unanesthetized and unrestrained rats

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Summary

The distances between the first and fifth digits and between the second and fourth digits of the rat's hind paw were measured after crushing the sciatic nerve. The distances between the digits recovered significantly faster in weak nerve crushing than in strong crushing, and faster in distal nerve crushing than in proximal crushing. These results suggest that this method is available for evaluating the functional recovery after nerve crushing.

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Authors and Affiliations

  1. Pharmacological Research, Central Research Laboratories, Sankyo Co., Ltd, Shinagawa-ku, 140, Tokyo, Japan

    K. Hasegawa

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  1. K. Hasegawa
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Acknowledgment. The author wishes to thank Dr. Yutaka Sakai for his valuable advice and support, Prof. Tsuneyuki Nakazawa (Department of Neuropsychiatry, School of Medicine, Fujita-Gukuen University) and Prof. Saburo Homma (Department of Physiology, School of Medicine, Chiba University) for their continuing guidance and encouragement, and Dr Shinsaku Kobayashi for his helpful suggestion and critical reading of the manuscript.

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Hasegawa, K. A new method of measuring functional recovery after crushing the peripheral nerves in unanesthetized and unrestrained rats. Experientia 34, 272–273 (1978). https://doi.org/10.1007/BF01944724

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  • DOI: https://doi.org/10.1007/BF01944724

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