Skip to main content
Log in

Non-host-selective fungal phytotoxins: Biochemical aspects of their mode of action

  • Multi-author Review
  • Published:
Experientia Aims and scope Submit manuscript

Abstract

During the last decade increasing attention has been directed towards the biochemical mechanisms responsible for the biological activity of phytotoxins. Studies on the mode of action of some non-host-selective phytotoxins, some following on from previous observations, have demonstrated a very specific interaction with particular components of the cell machinery, and have suggested the possible use of these phytotoxins as tools for the investigation of important biochemical processes. This review article reports and discusses results of studies carried out in the 1980s with seven non-host-selective fungal toxins: brefeldin A, cercosporin,Cercospora beticola toxin, fusicoccin, ophiobolins, tentoxin, and zinniol. Each of these interferes with the life of the host by interacting with a different biochemical target.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Aducci, P., and Ballio, A., Mode of action of fusicoccin: the role of specific receptors, in: Phytotoxins and Plant Pathogenesis, pp. 143–150. Eds. A. Graniti, R. D. Durbin and A. Ballio. Springer-Verlag. Berlin 1989.

    Chapter  Google Scholar 

  2. Aducci, P., and Marra, M., IP3 levels and their modulation by fusicoccin measured by a novel [3H]IP3 binding assay. Biochem. Biophys. Res. Commun168 (1990) 1041–1046.

    Article  CAS  PubMed  Google Scholar 

  3. Aducci, P., Ballio, A., Blein, J.-P., Fullone, M. R., Rossignol, M., and Scalla, R., Functional reconstitution of a proton-translocating system responsive to fusicoccin. Proc. natl. Acad. Sci. USA85 1988) 7849–7851.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Aducci, P., Ballio, A., Fiorucci, L., and Simonetti, E., Inactivation of solubilized fusicoccin-binding sites by endogenous plant hydrolases. Planta160 (1984) 422–427.

    Article  CAS  PubMed  Google Scholar 

  5. Aducci, P., Ballio, A., Fullone, M. R., and Persichetti, F., Entrapment into liposomes of fusicoccin binding sites, Plant Sci.45 (1986) 83–86.

    Article  CAS  Google Scholar 

  6. Aducci, P., Crosetti, G., Federico, R., and Ballio, A., Fusicoccin receptors. Evidence for endogenous ligand. Planta148 (1980) 208–210.

    Article  CAS  PubMed  Google Scholar 

  7. Aducci, P., Federico, R., and Ballio, A., Interaction of a high molecular weight derivative of fusicoccin with plant membranes. Phytopath. Medit.19 (1980) 187–188.

    CAS  Google Scholar 

  8. Aducci, P., Fullone, M. R., and Ballio, A., Properties of proteoliposomes containing fusicoccin receptors from maize. Plant Physiol.91 (1989) 1402–1406.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Arntzen, C. J., Inhibition of photophosphorylation by tentoxin, a cyclin tetraptptide. Biochim. Biophys. Acta283 (1972) 539–542.

    Article  CAS  PubMed  Google Scholar 

  10. Assante, G., Locci, R., Camarda, L., Merlini, L., and Nasini, G., Screening of the genusCercospora for secondary metabolites. Phytochemistry16 (1977) 243–247.

    Article  CAS  Google Scholar 

  11. Balis, C., and Payne, M. G., Triglycerides and Cercosporin fromCercospora beticola. Fungal growth and cercosporin production. Phytopathology61 (1971) 1477–1484.

    Article  CAS  Google Scholar 

  12. Ballio, A., Structure-activity relationship, in: Toxins in Plant Disease, pp. 395–441. Ed. R. D. Durbin. Academic Press, New York 1981.

    Chapter  Google Scholar 

  13. Ballio, A., and Aducci, P., Search for endogenous ligands to fusicoccin binding sites, in: Plant Hormone Receptors, pp. 125–130. Ed. D. Klämbt. Springer-Verlag, Berlin 1987.

    Chapter  Google Scholar 

  14. Ballio, A., Brufani, M., Casinovi, C. G., Cerrini, S., Fedeli, W., Pellicciari, R., Santurbano, B., and Vaciago, A., The structure of fusicoccin A. Experimentia24 (1968) 631–635.

    Article  CAS  Google Scholar 

  15. Ballio, A., Chain, E. B., De Leo, P., Erlanger, B. F., Mauri, M., and Tonolo, A., Fusicoccin: a new wilting toxin produced byFusicoccum amygdali Del. Nature203 (1964) 297.

    Article  CAS  Google Scholar 

  16. Ballio, A., De Michelis, M. I., Lado, P., and Randazzo, G., Fusicoccin structure-activity relationships: Stimulation of growth by cell enlargement and promotion of germination. Physiol. Plant.52 (1981) 471–475.

    Article  CAS  Google Scholar 

  17. Ballio, A., Federico, R., Pessi, A., and Scalorbi, D., Fusicoccin binding sites in subcellular preparations of spinach leaves. Plant Sci. Lett.18 (1980) 39–44.

    Article  CAS  Google Scholar 

  18. Ballio, A., Federico, R., and Scalorbi, D., Fusicoccin structure-activity relationships. In vitro binding to microsomal preparations of maize coleoptiles. Physiol. Plant.52 (1981) 476–481.

    Article  CAS  Google Scholar 

  19. Barasch, I., Mor, H., Netzer, D., and Kashman, Y., Production of zinniol byAltermaria dauci and its phytotoxic effect on carrot. Physiol. Plant Path.19 (1981) 7–16.

    Article  Google Scholar 

  20. Barbier-Brygoo, H., Ephritikhine, G., Klämbt, D., Ghislain, M., and Guern, J., Functional evidence for an auxin receptor at the plasmalemma of tobacco mesophyll protoplasts. Proc. natl Acad. Sci. USA86 (1989) 891–895.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Barrow, K. D., Barton, D. H. R., Chain, E., Ohnsorge, U. F. W., and Thomas, R., Fusicoccin. Part II. The constitution of fusicoccin. J. chem. Soc. (C) (1971) 1265–1274.

  22. Blein, J.-P., Bourdil, I., Rossignol, M., and Scalla, R.,Cercospora beticola toxin inhibits vanadate-sensitive H+ transport in corn root membrane vesicles. Plant Physiol.88 (1988) 429–434.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Blum, W., Key, G., and Weiler, E. W., ATPase activity in plasmalemma-rich vesicles isolated by aqueous two-phase partitionning fromVicia faba mesophyll and epidermis: Characterization and influence of abscisic acid and fusicoccin. Physiol. Plant.72 (1988) 297–287.

    Article  Google Scholar 

  24. Böcher, M., and Novacky, A., Effect of tentoxin on the membrane potential ofLemma gibba G1. Plant Sci. Lett.23 (1981) 269–276.

    Article  Google Scholar 

  25. Cavallini, L., Bindoli, A., Macri, F., and Vianello, A., Lipid peroxidation induced by cercosporin as a possible determinant of its toxicity. Chem.-biol. Interact.28 (1979) 139–146.

    Article  CAS  PubMed  Google Scholar 

  26. Chattopadhyay, A. K., and Samaddar, K. R., Effects ofHelminthosporium oryzae infection and ophiobolin on the cell membranes of host tissues. Physiol. Plant Path.8 (1976) 131–139.

    Article  CAS  Google Scholar 

  27. Cocucci, S. M., Morgutti, S., Cocucci, M., and Gianani, L., Effects of ophiobolin A on potassium permeability, transmembrane electrical potential and proton extrusion in maize roots. Plant Sci. Lett.32 (1983) 9–16.

    Article  CAS  Google Scholar 

  28. Cotty, P. J., Misaghi, I. J., and Hine, R. B., Production of zinniol byAlternaria tagetica and its phytotoxic effect onTagetes erecta. Phytopathology73 (1983) 1326–1328.

    Article  CAS  Google Scholar 

  29. Dahse, I., Bulychev, A. A., Kurella, G. A., and Liebermann, B., Weak tentoxin effect on the electrical light response of isolated chloroplasts ofPeperomia metallica. Physiol. Plant.65 (1985) 446–450.

    Article  CAS  Google Scholar 

  30. Dahse, I., Matorin, D. N., and Liebermann, B. A., A comparison of tentoxin action on the delayed fluorescence in chloroplasts of spinach,Chlorella andAnacystis. Biochem. Physiol. Pflanzen181 (1986) 137–146.

    Article  CAS  Google Scholar 

  31. Dahse, I., Schnabl, H., Hampp, R., Ziegler, H., Müller, E., and Liebermann, B., Inhibition of light-induced stomatal opening and of guard-cell-protoplast swelling inVicia faba L. by tentoxin, an inhibitior of photophosphorylation. Planta173 (1988) 391–396.

    Article  CAS  PubMed  Google Scholar 

  32. Daly, J. M., Mechanism of action, in: Toxins in Plant Disease, pp. 331–394. Ed. R. D. Durbin. Academic Press, New York 1981.

    Chapter  Google Scholar 

  33. Daub, M. E., Cercosporin, a photosensitizing toxin fromCercospora species. Phytopathology72 (1982) 370–374.

    Article  CAS  Google Scholar 

  34. Daub, M. E., Peroxidation of tobacco membrane lipids by the photosensitizing toxin, cercosporin. Plant Physiol.69 (1982) 1361–1364.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Daub, M. E., and Briggs, S. P., Changes in tobacco cell membrane composition and structure caused by cercosporin. Plant Physiol.71 (1983) 763–766.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Daub, M. E., and Hangarter, R. P., Ligh-induced production of singlet oxygen and superoxide by the fungal toxin cercosporin. Plant Physiol.73 (1983) 855–857.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. de Boer, A. H., Watson, B. A., and Cleland, R. E., Purification and identification of the fusicoccin binding protein from oat root plasma membrane. Plant Physiol.89 (1989) 250–259.

    Article  PubMed  PubMed Central  Google Scholar 

  38. De Michelis, M. I., Pugliarello, M. C., Olivari, C., and Rasi-Caldogno, F., On the mechanism of FC-induced activation of the plasma membrane H+-ATPase, in: Plant Membrane Transport, pp. 373–378. Eds J. Dainty, M. I. De Michelis, E. Marrè and F. Rasi-Caldogno. Elsevier, Amsterdam 1989.

    Google Scholar 

  39. De Michelis, M. I., Pugliarello, M. C., and Rasi-Caldogno, F., Fusicoccin binding to its plasma membrane receptor and the activation of the plasma membrane H+-ATPase. I. Characteristics and intracellular localization of the fusicoccin receptor in microsomes from radish seedlings. Plant Physiol.90 (1989) 133–139.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Dobrowolski, D. C., and Foote, C. S., Cercosporin, a singlet oxygen generator. Angew. Chem. Int. Ed. Engl.22 (1983) 720–721.

    Article  Google Scholar 

  41. Dohrmann, U., Hertel, R., Pesci, P., Cocucci, S. M., Marrè, E., Randazzo, G., and Ballio, A., Localization of in vitro binding of the fungal toxin fusicoccin to plasmamembrane-rich fractions from corn coleoptiles. Plant Sci. Lett.9 (1977) 291–299.

    Article  CAS  Google Scholar 

  42. Duke, S. O., and Vaughn, K. C., Lack of involvement of polyphenol oxidase in ortho-hydroxylation of phenolic compounds in mung bean seedlings. Physiol. Plant.54 (1982) 381–385.

    Article  CAS  Google Scholar 

  43. Durbin, R. D., and Uchytil, T. F., The effect of tentoxin on fusicoccin-induced stomatal opening. Phytopath. Medit.15 (1976) 62–63.

    Google Scholar 

  44. Durbin, R. D., Uchytil, T. F., and Sparapano, L., The effect of tentoxin on stomatal aperture and potassium content of guard cells. Phytopathology63 (1973) 1077–1078.

    Article  CAS  Google Scholar 

  45. Fajola, A. O., Cercosporin, a phytotoxin fromCercospora spp. Physiol. Plant Path.13 (1978) 157–164.

    Article  CAS  Google Scholar 

  46. Feyerabend, M., and Weiler, E. W., Characterization and localization of fusioccin-binding sites in leaf tissues ofVicia faba L. probed with a novel radioligand. Planta174 (1988) 115–122.

    Article  CAS  PubMed  Google Scholar 

  47. Feyerabend, M., and Weiler, E. W., Photoaffinity labelling and partial purification of the putative plant receptor for the fungal wilt-inducing toxin fusicoccin. Planta178 (1989) 282–290.

    Article  CAS  PubMed  Google Scholar 

  48. Fujiwara, T., Oda, K., Yokota, S., Takatsuki, A., and Ikehara, Y., Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum. J. biol. Chem.263 (1988) 18 545–18 552.

    Article  CAS  Google Scholar 

  49. Fulton, N. O., Bollenbacher, K., and Templeton, G. E., A metabolite fromAlternaria tenuis that inhibits chlorophyll production. Phytopathology55 (1965) 49–51.

    CAS  Google Scholar 

  50. Gianani, L., Cocucci, S., and Morgutti, S., Ophiobolin A and fusicoccin interaction on proton extrusion from Maize roots. Phytopath. Medit.19 (1980) 191–192.

    CAS  Google Scholar 

  51. Gianani, L., Cocucci, S., Pardi, D., and Randazzo, G., Effects of ophiobolin B on cell enlargement and H+/K+ exchange in maize coleoptile tissues. Planta146 (1979) 271–274.

    Article  CAS  PubMed  Google Scholar 

  52. Hager, A., Hampp, R., and Mehrle, W., Mechanism of growth induction by ester compounds. Studies with segments and protoplasts of oat coleoptiles. in: Plant Growth Substances 1985, pp. 284–292. Ed. M. Bopp. Springer-Verlag, Berlin 1986.

    Google Scholar 

  53. Hartman, P. E., Dixon, W. J., Dahl, T. A., and Daub, M. E., Multiple modes of photodynamic action by cercosporin. Photochem. Photobiol.47 (1988) 699–703.

    Article  CAS  PubMed  Google Scholar 

  54. Hartman, P. E., Suzuki, C. K., and Stack, M. E., Photodynamic production of superoxide in vitro by altertoxins in the presence of reducing agents. Appl. envir. Microbiol.55 (1989) 7–14.

    Article  CAS  Google Scholar 

  55. Heitz, F., Jacquier, R., Kaddari, F., and Verducci, J., Aggregation and ion transfer induced by tentoxin. Biophys. Chem.23 (1986) 245–249.

    Article  CAS  PubMed  Google Scholar 

  56. Heitz, F., Kaddari, F., Van Mau, N., Verducci, J., Raniri Seheno, H., and Lazaro, R., Ionic pores formed by cyclic peptides. Biochimie71 (1989) 71–76.

    Article  CAS  PubMed  Google Scholar 

  57. Horner, R. D., Froehlich, J. P., and Moudrianakis, F. N., Initial products of photophosphorylation with AMP and (32P)Pi. J. biol. Chem.258 (1983) 5618–5622.

    Article  CAS  PubMed  Google Scholar 

  58. Hradil, C. M., Hallock, Y. F., Clardy, J., Kenfield, D. S., and Strobel, G., Phytotoxins fromAlternaria cassiae. Phytochemistry28 (1989) 73–75.

    Article  CAS  Google Scholar 

  59. Klotz, M. G., Gündel, J., Müller, E., and Liebermann, B., Tentoxin action on the electric properties of a lipid bilayer membrane. Stud. Biophys.90 (1982) 53–54.

    Google Scholar 

  60. Kohlbrenner, W. E., and Boyer, P. D., Probes of catalytic site cooperativity during catalysis by the chloroplast adenosine triphosphate and the adenosine triphosphate synthase. J. biol. Chem.258 (1983) 10 881–10 886.

    Article  CAS  Google Scholar 

  61. Kojima, M., and Takeuchi, W., Detection and characterization ofp-coumaric acid hydroxylase in mung bean,Vigna mungo, seedlings. J. Biochem.105 (1989) 265–270.

    Article  CAS  PubMed  Google Scholar 

  62. Kuyama, S., and Tamura, T., Cercosporin A pigment ofCercosporina kikuchii Matsumoto et Tomoyasu. I. Cultivation of fungus, isolation and purification of pigment. J. Am. Chem. Soc.79 (1957) 5725–5726.

    Article  CAS  Google Scholar 

  63. Leung, P. C., Graves, L. M., and Tipton, C. L., Characterization of the interaction of ophiobolin A and calmodulin. Int. J. Biochem.20 (1988) 1351–1359.

    Article  CAS  PubMed  Google Scholar 

  64. Leung, P. C., Taylor, W. A., Wang, J. H., and Tipton, C. L., Role of calmodulin inhibition in the mode of action of Ophiobolin A. Plant Physiol.77 (1985) 303–308.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  65. Leung, P. C., Taylor, W. A., Wang, J. H., and Tipton, C. L., Ophiobolin A, a natural product inhibitor of calmodulin. J. biol. Chem.259 (1984) 2742–2747.

    Article  CAS  PubMed  Google Scholar 

  66. Lippincott-Schwartz, J., Donaldson, J. G., Schweizer, A., Berger, E. G., Hauri, H. P., Yuan, L. C., and Klausner, P. D., Microtubuledependent retrograde transport of proteins into the ER in the presence of brefeldi. A suggests an ER recycling pathway. Cell60 (1990) 821–836.

    Article  CAS  PubMed  Google Scholar 

  67. Lippincott-Schwartz, J., Yuan, L. C., Bonifacino, J. S., and Klausner, R. D., Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER. Cell56 (1989) 801–813.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  68. Macri, F., and Vianello, A., Inhibition of K+ uptake, H+ extrusion and K+-activated ATPase, and depolarization of transmembrane potential in plant tissues treated withCercospora beticola toxin. Physiol. Plant Path.15 (1979) 161–170.

    Article  CAS  Google Scholar 

  69. Macri, F., and Vianello, A., Photodynamic activity of cercosporin on plant tissues. Plant Cell Envir.2 (1979) 267–271.

    Article  Google Scholar 

  70. Macri, F., and Vianello, A., Photodynamic activity of compounds structurally related to cercosporin. Agric. biol. Chem.44 (1980) 2967–2960.

    CAS  Google Scholar 

  71. Macri, F., Del'Anntone, P., and Vianello, A., ATP-dependent proton uptake inhibited byCercospora beticola toxin in pea stem microsomal vesicles. Plant Cell Eavir.6 (1983) 555–558.

    Article  CAS  Google Scholar 

  72. Marra, M., Aducci, P., and Ballio, A., Immunoaffinity chromatography of fusicoccin. J. Chronat.440 (1988) 47–51.

    CAS  Google Scholar 

  73. Marra, M., Aducci, P., and Ballio, A., Immunoaffinity chromatography of endogenous ligands for fusicoccin binding sites, in: Phytotoxins and Plant Pathogenesis, pp. 359–361. Eds A. Graniti, R. D. Durbin and A. Ballio. Springer-Verlag, Berlin 1989.

    Google Scholar 

  74. Marrè, E., Fusicoccin: a tool in plant physiology. A. Rev. Plant Physiol.30 (1979) 273–288.

    Article  Google Scholar 

  75. Marrè, E., Mechanism of action of phytotoxins affecting plasmalemma functions. Progr. Phytochem.6 (1980) 253–284.

    Google Scholar 

  76. Marrè, E., Fusicoccin and hormone-induced changes of H+ extrusion: physiological implications, in: Frontiers of Membrane Research in Agriculture, pp. 429–460. Eds. J. B. St. John, E. Berlin and P. C. Jackson. Rowman & Allanheld. Totowa 1985.

    Google Scholar 

  77. Marrè, E., Marrè, M. T., and Romani, G., Action of fusicoccinin vivo: Physiological and biochemical consequences, in: Phytotoxins and Plant Pathogenesis, pp. 131–141. Eds. A. Graniti, R. D. Durbin and A. Ballio. Springer-Verlag, Berlin 1989.

    Chapter  Google Scholar 

  78. Martin, J. A., and Vogel, E., The synthesis of zinniol. Tetrahedron36 (1980) 791–794.

    Article  CAS  Google Scholar 

  79. Meyer, C., Feyerabend, M., and Weiler, E. M., Fusicoccin-binding proteins inArabidopsis thaliana(L)Heynh. characterization solubilization and photoaffinity labelling. Plant Physiol.89 (1989) 692–699.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  80. Meyer, W. L., Kuyper, L. F., Phelps, D. W., and Cordes, A. W., Structure of the cyclic tetrapeptide tentoxin. Crystal and molecular structure of the dihydro derivative. J. Chem. Soc. chem. Commun. (1974) 399–400.

  81. Misumi, Y., Misumi, Y., Miki, K., Takatsuki, A., Tamura, G., and Ikehara, Y., Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes. J. biol. Chem.261 (1986) 11 398–11 403.

    Article  CAS  Google Scholar 

  82. Nejidat, A., Effect of ophiobolin A on stomatal movement. Role of calmodulin. Plant Cell Physiol.28 (1987) 455–460.

    CAS  Google Scholar 

  83. Oda, K., Hirose, S., Takami, N., Misumi, Y., Takatsuki, A., and Ikehara, Y., Brefeldin A arrests the intracellular transport of a precursor of complement C3 before its conversion site in rat hepatocytes. FEBS Lett.214 (1987) 135–138.

    Article  CAS  PubMed  Google Scholar 

  84. Oku, H., Role of parasitic enzymes and toxins in development of characteristic symptoms in plant disease, in: The Dynamic Role of Molecular Constituents in Plant-Parasite Interaction, pp. 237–255. Eds C. J. Mirocha and I. Uritani, Bruce Publ. Co., St. Paul, Minn. 1967.

    Google Scholar 

  85. Orsenigo, M., Estrazione e purificazione dellaCochiiobolina, una tossina prodotta daHelminhosporium oryzae. Phytopath. Z.29 (1957) 189–196.

    Google Scholar 

  86. Orsenigo, M., Osservazioni preliminari sul meccanismo d'azione della cochliobolina. Giorn. Bot. Ital.68 (1961) 250–252.

    Article  Google Scholar 

  87. Pick, U., and Weiss, M., A light-dependent dicyclohexylcarbodiimide-sensitive Ca-ATPase activity in chloroplasts which is not coupled to proton translocation. Eur. J. Biochem.173 (1988) 623–628.

    Article  CAS  PubMed  Google Scholar 

  88. Quick, W. P., and Mills, J. D., Thiol modulation of chloroplast CF0-CF1 in isolated barley protoplasts and its significance to regulation of carbon dioxide fixation. Biochim. biophys. Acta851 (1986) 166–172.

    Article  CAS  Google Scholar 

  89. Quick, P., Scheibe, R., and Stitt, M., Use of tentoxin and nigericin to investigate the possiblecontribution of ΔpH to energy dissipation and the control of electron transport in spinach leaves. Biochim. biophys. Acta974 (1989) 282–288.

    Article  CAS  Google Scholar 

  90. Racker, E., Violand, B., O'Neill, S., Alfonzo, M., and Telford, J., Reconstitution, a way of biochemical research: some new approaches to membrane bound enzymes. Archs Biochem. Biophys.198 (1979) 470–477.

    Article  CAS  Google Scholar 

  91. Rasi-Caldogno, F., and Pugliarello, M. C., Fusicoccin stimulates the H+-ATPase of plasmalemma in isolated membrane vesicles from radish. Biochem. biophys. Res. Commun.133 (1985) 280–285.

    Article  CAS  PubMed  Google Scholar 

  92. Rasi-Caldogno, F., De Michelis, M. I., Pugliarello, M. C., and Marrè, E., H+-pumping driven by the plasma membrane ATPase in membrane vesicles from radish: stimulation by fusicoccin. Plant Physiol.82 (1986) 121–125.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  93. Richter, M. L., Gromet-Elhanan, Z., and McCarty, R. E., Reconstitution of the H+-ATPase complex ofRhodospirillum rubrum by the β-subunit of the chloroplast coupling factor 1. J. biol. Chem.261 (1986) 12 109–12 113.

    Article  CAS  Google Scholar 

  94. Robeson, D. J., and Strobel, G. A., Zinniol induces chlorophyll retention in barley leaves: the selective action of a non-host-specific phytotoxin. Phytochemistry23 (1984) 1597–1599.

    Article  CAS  Google Scholar 

  95. Robeson, D., Strobel, G., Matsumoto, G. K., Fisher, E. L., Chen, M. H., and Clardy, J., Alteichin: an unusual phytotoxin fromAlternaria eichorniae, a fungal pathogen of water hyacinth. Experientia40 (1984) 1248–1250.

    Article  CAS  PubMed  Google Scholar 

  96. Rossignol, M., Bourdil, I., Santoni, V., and Blein, J.-P., Interaction between plasma membrane H+-ATPase and phytotoxins: use of reconstituted systems, in: Plant Membrane Transport, pp. 379–384. Eds. J. Dainty, M. I. De Michelis, E. Marrè and F. Rasi-Caldogno. Elsevier, Amsterdam 1989.

    Google Scholar 

  97. Schlösser, E., Über eine biologisch aktive Substanz ausCercospora beticola. Phytopath. Z.44 (1962) 295–312.

    Article  Google Scholar 

  98. Schlösser, E., TheCercospora beticola toxin. Phytopath. Medit.10 (1971) 154–158.

    Google Scholar 

  99. Schröder, M., Schulz, S., and Weiler, E. W., The growth-promoting fungal toxin fusicoccin does not act through an ester-hydrolysis mechanism in plants. Naturwissenschaften77 (1990) 82–83.

    Article  Google Scholar 

  100. Schwartz, A., The role of Ca2+ and EGTA on stomatal movements inCommelina communis L. Plant Physiol.79 (1985) 1003–1005.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  101. Shoshan, V., and Selman, B. R., Tentoxin inhibition of the light-dependent exchange of chloroplast coupling factor 1 tightly bound adenine nucleotides. J. biol. Chem.254 (1979) 8808–8813.

    Article  CAS  PubMed  Google Scholar 

  102. Singleton, V. L., and Bohonos, N., Chemical characterization of the mold product decumbin. Agric. biol. Chem.28 (1964) 77–81.

    Article  CAS  Google Scholar 

  103. Singleton, V. L., Bohonos, N., and Ullstrup, A. J., Decumbin, a new compound from a species ofPenicillium. Nature181 (1958) 1072–1073.

    Article  CAS  PubMed  Google Scholar 

  104. Starratt, A. N., Zinniol: a major metabolite ofAlternaria zinniae. Can. J. Chem.46 (1968) 767–770.

    Article  CAS  Google Scholar 

  105. Steele, J. A., Uchytil, T. F., Durbin, R. D., Bhatnagar, P., and Rich, D. H., Chloroplast coupling factor 1. A species-specific receptor for tentoxin. Proc. natl Acad. Sci. USA73 (1976) 2245–2248.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  106. Steinkamp, M. P., Martin, S. S., Hoefert, L. L., and Ruppel, E. G., Ultrastructure of lesions produced byCercospora beticola in leaves ofBeta vulgaris. Physiol. Plant Path.15 (1979) 13–26.

    Article  Google Scholar 

  107. Steinkamp, M. P., Martin, S. S., Hoefert, L. L., and Ruppell, E. G., Ultrastructure of lesions produced in leaves ofBeta vulgaris by cercosporin, a toxin fromCercospora beticola. Phytopathology71 (1981) 1272–1281.

    CAS  Google Scholar 

  108. Stoessl, A., Structure and biogenetic relations: Fungal non-host-specific, in: Toxins in Plant Disease, p. 151. Ed R. D. Durbin. Academie Press, New York 1981.

    Google Scholar 

  109. Stout, R. G., Fusicoccin activity and binding inArabidopsis thaliana. Plant Physiol.88 (1988) 999–1001.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  110. Stout, R. G., and Cleland, R. E., Partial characterization of fusicoccin binding to receptor sites on oat root membranes. Plant Physiol.66 (1980) 353–359.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  111. Sugawara, F., and Strobel, G., Zinniol, a phyytotoxin, is produced byPhoma macdonaldii. Plant Sci.43 (1986) 19–23.

    Article  CAS  Google Scholar 

  112. Suzuki, Y., Tanaka, H., Aoki, H., aand Tamura, T., Ascotoxin(decumbin), a metabolite ofAscochyta imperfecta peck. Agric. biol. Chem.34 (1970) 395–413.

    CAS  Google Scholar 

  113. Templeton, G. E.,Alternaria toxin related to pathogenesis in plants, in: Microbial Toxins, vol. 8, pp. 160–192. Eds S. Kadis, A. Ciegler and S. J. Aji. Academic Press, New York 1972.

    Google Scholar 

  114. Thuleau, P., Graziana, A., Rossignol, M., Kauss, H., Auriol, P., and Ranjeva, R., Binding of the phytotoxin zinniol stimulates the entry of calcium into plant protoplasts. Proc. natl Acad. Sci. USA85 (1988) 5932–5935.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  115. Tietjen, K. G., and Matern, U., Induction and suppression of phytoalexin biosynthesis in cultured cells of safflower,Carthamus tinctorius L., by metabolites ofAlternaria carthami Chowdhury. Archs Biochem. Biophys.229 (1984) 136–144.

    Article  CAS  Google Scholar 

  116. Teitjen, K. G., Hammer, D., and Matern, U., Determination of toxin distribution inAlternaria leaf spot diseased tissue by radioimmunoassay. Physiol. Plant Path.26 (1985) 241–257.

    Article  Google Scholar 

  117. Tietjen, K. G., Schaller, E., and Matern, U., Phytotoxins fromAlternaria carthami Chowdhury: structural identification and physiological significance. Physiol. Plant Path.23 (1983) 387–400.

    Article  CAS  Google Scholar 

  118. Tipton, C. L., Paulsen, P. V., and Betts, R. E., Effects of ophiobolin-A on ion leakage and hexose uptake by maize roots. Plant Physiol.59 (1977) 907–910.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  119. Tognoli, L., Beffagna, N., Pesci, P., and Marrè, E., On the relationship between ATPase activity and FC binding capacity of crude and partially purified microsomal preparations from maize coleoptiles. Plant Sci. Lett.16 (1979) 1–14.

    Article  CAS  Google Scholar 

  120. Takatsuki, A., and Tamura, G., Brefeldin A, a specific inhibitor of intracellular translocation of vesicular stomatitis virus G protein: Intracellular accumulation of high-mannose type G protein and inhibition of its cell surface expression. Agric. biol. Chem.49 (1985) 899–902.

    CAS  Google Scholar 

  121. Turner, N. C., and Graniti, A., Fuscioccin, a fungal toxin that opens stomata. Nature223 (1969) 1070–1071.

    Article  CAS  Google Scholar 

  122. Ulmer, J. B., and Palade, G. E., Targeting and processing of glycophorins in murine erythroleukemia cells. Use of brefeldin A as a perturbant of intracellular traffic. Proc. natl Acad. Sci. USA86 (1989) 6992–6996.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  123. Vaughn, K. C., and Duke, S. O., Tentoxin-induced loss of plastidic polyphenol oxidase. Physiol. Plant.53 (1981) 421–428.

    Article  CAS  Google Scholar 

  124. Venkataramani, K., Isolation of Cercosporin fromCercospora personata. Phytopath. Z.58 (1967) 379–382.

    Article  CAS  Google Scholar 

  125. Weiss, U., Merlini, L., and Nasini, G., Naturally occurring perylenquinones, in: Progress in the Chemistry of Organic Natural products, vol. 52, pp. 1–71. Eds W. Herz, H. Grisebach, G. W. Kirby and Ch. Tamm. Springer-Verlag, Wien 1987.

    Google Scholar 

  126. White, G. A., and Starratt, A. N., The production of a phytotoxic substance byAlternaria zinniae. Can. J. Bot.45 (1967 2087–2290.

    Article  CAS  Google Scholar 

  127. Willmer, C. M., and Mansfield, T. A., A critical examination of the use of detached epidermis in studies of stomatal physiology. New Phytol.68 (1969) 363–375.

    Article  Google Scholar 

  128. Yamazaki, S. A., Okubo, A., Akiyama, Y., and Fuwa, K., Cercosporin, a novel photodynamic pigment isolated fromCercospora kikuchii. Agric. biol. Chem.39 (1975) 287–288.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ballio, A. Non-host-selective fungal phytotoxins: Biochemical aspects of their mode of action. Experientia 47, 783–790 (1991). https://doi.org/10.1007/BF01922458

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01922458

Key words

Navigation