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Accumulation of 2-μm latex particles in mouse Peyer's patches during chronic latex feeding

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Summary

2-μm latex particles accumulated in macrophages in intestinal Peyer's patches of mice given latex suspensions as drinking fluid for 2 months. The number of particles accumulating was a direct (but nonlinear) function of the number ingested. Some of the latex particles were still present in Peyer's patches 6 weeks after the cessation of latex feeding.

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Author notes

  1. J. W. Vanderhoff

    Present address: Center for Surface and Coatings Research, Lehigh University, 18015, Bethlehem, Pa.

  2. J. A. Laissue

    Present address: Pathologisches Institut, Kantonsspital, CH-6000, Luzern, Switzerland

Authors and Affiliations

  1. Medical Research Center, Brookhaven National Laboratory, 11973, Upton, New York, USA

    M. E. LeFevre, J. W. Vanderhoff, J. A. Laissue & D. D. Joel

Authors
  1. M. E. LeFevre
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  2. J. W. Vanderhoff
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  3. J. A. Laissue
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  4. D. D. Joel
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Additional information

Acknowledgments. Research supported by the U. S. Energy Research and Development Administration. We thank Mr W. Marin, Division of Photography and Graphic Arts, Brookhaven National Laboratory, for figure 2.

The research described in this report involved animals maintained in animal care facilities fully accredited by the American Association for Accreditation of Laboratory Animal Care.

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LeFevre, M.E., Vanderhoff, J.W., Laissue, J.A. et al. Accumulation of 2-μm latex particles in mouse Peyer's patches during chronic latex feeding. Experientia 34, 120–122 (1978). https://doi.org/10.1007/BF01921939

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  • DOI: https://doi.org/10.1007/BF01921939

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