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Compatibility problems of chlorpromazine HCl-stearate lubricants examined by differential scanning calorimetry

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Abstract

Differential scanning calorimetry (DSC) was used to investigate the interactions between chlorpromazine HCl (CPZ) and stearate lubricants. The phase diagram was constructed for each CPZ-stearate system. An unknown endothermic peak at 145°C was found for the CPZ-stearate lubricants; this was affected by the grinding and heating processes. This unknown endothermic peak proved to relate to a polymorphism transition but was not an incompatibility problem. Three polymorphisms of CPZ were also determined by DSC analysis and IR spectrophotometry.

Zusammenfassung

Mittels DSC wurden die Wechselwirkungen zwischen ChlorpromazinHCl (CPZ) und Stearatgleitmitteln untersucht. Für jedes CPZ-Stearat-System wurde das Phasendiagramm erstellt. Bei CPZ-Stearatgleitmitteln ergab sich bei 145°C ein unbekannter endothermer Peak, der durch Zerkleinerungs- und Erhitzungsprozesse beeinflußt wurde. Dieser unbekannte endotherme Peak scheint einer polymorphen Umwandlung zu entsprechen, stellte jedoch kein Inkompatibilitätsproblem dar. Weiterhin wurden mittels DSC und IR-Spektroskopie drei Polymorphien von CPZ festgestellt.

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Authors and Affiliations

  1. Biopharmaceutics Laboratory, Department of Medical Research, Veterans General Hospital-Taipei, Shih-Pai, Taipei, Republic of China

    Shan-Yang Lin & Yuh-Horng Kao

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  1. Shan-Yang Lin
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  2. Yuh-Horng Kao
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Lin, SY., Kao, YH. Compatibility problems of chlorpromazine HCl-stearate lubricants examined by differential scanning calorimetry. Journal of Thermal Analysis 36, 2493–2504 (1990). https://doi.org/10.1007/BF01913646

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  • DOI: https://doi.org/10.1007/BF01913646

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