Skip to main content
SpringerLink
Log in

Cardiocirculatory adjustments to exercise following myocardial infarction in rats

  • Original Contributions
  • Published:
Basic Research in Cardiology Aims and scope Submit manuscript

Summary

The sequential changes of the cardiocirculatory response to exercise over time in rats with myocardial infarction and failure were studied. Hemodynamics and regional blood flow (RBF, radioactive microspheres) were determined at rest and during exercise either at 1, 10 or 42 days after infarction (MI, infarct size 41.4±2.6% of LV) or sham procedures (SH). Whereas the response to exercise was attenuated one day after surgery in MI and SH, cardiocirculatory recovery was present in SH at 10 days and LV systolic and end-diastolic pressures separated SH and MI groups. Renal vasoconstriction during exercise occurred 10 days after MI and BF to working muscle during exercise was significantly lower in MI as compared to SH. At 42 days after MI manifest heart failure was present and despite significant blood flow redistribution (p<0.05 MI vs SH in renal and cutaneous beds) impaired skeletal muscle flow was observed along with increased vascular resistance in working muscle during exercise. We conclude that the cardiocirculatory response to exercise following large MI follows a distinctive time-dependent pattern, which differs from that observed at rest. Besides exaggerated sympathetically mediated vasoconstriction during exercise, impaired vasodilatation in skeletal muscle at exercise emerged.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Alder HL, Roessler EB (1972) Introduction to probability and statistics. Freeman, San Francisco pp 280–314

    Google Scholar 

  2. Benge W, Litchfield RL, Marcus ML (1980) Exercise capacity in patients with severe left ventricular dysfunction. Circulation 61:955–959

    PubMed  Google Scholar 

  3. Bruce RA (1977) Exercise testing for evaluation of ventricular function. N Engl J Med 296:671

    PubMed  Google Scholar 

  4. Drexler H, Depenbusch JW, Truog AG, Zelis R, Flaim SF (1985) Effects of diltiazem on cardiac function and regional blood flow at rest and during exercise in a conscious rat model of chronic heart failure (myocardial infarction). Circulation 71:1262–1270

    PubMed  Google Scholar 

  5. Epstein SE, Beiser GD, Stampfer M, Robinson BF, Braunwald E (1967) Characterization of the circulatory response to maximal upright exercise in normal subjects and patients with heart disease. Circulation 35:1049–1062

    PubMed  Google Scholar 

  6. Fishbein MC, Maclean D, Maroko PR (1978) Experimental myocardial infarction in the rat. Am J Pathol 90:57

    PubMed  Google Scholar 

  7. Flaim SF, Minteer WJ, Clark DP Zelis R (1979) Cardiovascular response to acute aquatic and treadmill exercise in the untrained rat. Am J Physiol 46:302–308

    Google Scholar 

  8. Flaim SF, Minteer WJ (1980) Ventricular volume overload alters cardiac output distribution in rats during exercise. J Appl Physiol 49:482–490

    PubMed  Google Scholar 

  9. Flaim SF, Nellis SH, Toggart EJ, Drexler H, Kanda K, Newman ED (1984) Multiple simultaneous determinations of hemodynamics and flow distribution in conscious rat. J Pharmacol Methods 11:1–38

    Article  PubMed  Google Scholar 

  10. Francis GS, Goldsmith SR, Cohn JN (1982) Relationship of exercise capacity to resting left ventricular performance and basal plasma norepinephrine levels in patients with congestive heart failure. Am Heart J 104:725–731

    Article  PubMed  Google Scholar 

  11. Francis GF, Goldsmith SR, Ziesche SM, Cohn JN (1982) Response of plasma norepinephrine and epinephrine to dynamic exercise in patients with congestive heart failure. Am J Cardiol 49:1152–1156

    PubMed  Google Scholar 

  12. Goldstein RE, Beiser GD, Stampfer M, Epstein SE (1975) Impairment of automatically mediated heart rate control in patients with cardiac dysfunction. Circ Res 36:571–578

    PubMed  Google Scholar 

  13. Haskel WL, DeBusk R (1979) Cardiovascular responses to repeated treadmill exercise testing soon after myocardial infarction. Circulation 60:1247–1252

    PubMed  Google Scholar 

  14. Hecht HS, Karahalios SE, Ormiston JA, Schnugg SD, Hopkins JM, Singh BN (1982) Pattern of exercise response in patients with severe left ventricular dysfunction: radionuclide ejection fraction and hemodynamic cardiac performance evaluations. Am Heart J 104:718–724

    Article  PubMed  Google Scholar 

  15. Heymann MA, Payne BD, Hoffman JIE, Rudolph AM (1977) Blood flow measurements with radionuclide-labeled particles. Prog Cardiovasc Res 20:55–79

    Google Scholar 

  16. Ishise S, Pegram BL, Yamamoto J, Kitamura Y, Frohlich ED (1980) Reference sample microsphere method: Cardiac output and blood flows in conscious rat. Am J Physiol 239:H443-H449

    PubMed  Google Scholar 

  17. Mason DT, Zelis R, Longhurst J, Lee G (1977) Cardiocirculatory responses to muscular exercise in congestive heart failure. Prog Cardiovasc Dis 29:475–489

    Article  Google Scholar 

  18. Millard RW, Higgins CB, Franklin D, Vatner SF (1972) Regulation of the renal circulation during severe exercise i normal dogs and dogs with experimental heart failure. Circ Res 31:881–888

    PubMed  Google Scholar 

  19. Miller DH, Borer JS (1982) Exercise testing early after myocardial infarction. Am J Med 72:427–437

    Article  PubMed  Google Scholar 

  20. Morris SN, Phillips JF, Jordan JW, McHenry LP (1978) Incidence and significance of decreases in systolic blood pressure during graded treadmill exercise testing. Am J Cardiol 41:221

    Article  PubMed  Google Scholar 

  21. Port S, McEwan P, Cobb FR, Jones RH (1981) Influence of resting left ventricular function on the left ventricular response to exercise in patients with coronary artery disease. Circulation 63:856–863

    PubMed  Google Scholar 

  22. Riegger AJR, Liebau G (1982) The renin-angiotensin aldosteron system, antidiuretic hormone and sympathetic nerve activity in an experimental model of congestive heart failure in the dog. Clin Sci 62:465–469

    PubMed  Google Scholar 

  23. Ross J, Gault JH, Mason DT, Linhart JW, Braunwald E (1966) Left ventricular performance during muscular exercise in patients with and without cardiac dysfunction. Circulation 34:597–608

    PubMed  Google Scholar 

  24. Smith HJ, Nuttal A (1985) Experimental models of heart failure. Cardiovasc Res 19:181–186

    PubMed  Google Scholar 

  25. Vatner SF, Higgins CB, Franklin D (1972) Regional circulatory adjustments to moderate and severe chronic anemia in conscious dogs at rest and during exercise. Circ Res 30:731

    PubMed  Google Scholar 

  26. Wagner HN, Rhodes BA, Sasaki Y, Ryan JP (1969) Studies of the circulation with radioactive microspheres. Invest Radiol 4:374–386

    PubMed  Google Scholar 

  27. Weber KT, Kinasewitz GT, Janicki JS, Fishman AP (1982) Oxygen utilization and ventilation during exercise in patients with chronic cardiac failure. Circulation 65:1213–1223

    PubMed  Google Scholar 

  28. Wilson JR, Martin JL, Schwartz D, Ferraro N (1984) Exercise intolerance in patients with chronic heart failure: role of impaired nutritive flow to skeletal muscle. Circulation 69:1079–1087

    PubMed  Google Scholar 

  29. Wilson JR, Martin JL, Ferraro N (1984) Impaired skeletal muscle nutritive flow during exercise in patients with congestive heart failure: role of cardiac pump dysfunction as determined by the effect of dobutamine. Am J Cardiol 53:1308–1315

    Article  PubMed  Google Scholar 

  30. Wilson JR, Ferraro N (1985) Effect of the renin-angiotensin-system on limb circulation and metabolism during exercise in patients with heart failure. J Am Coll Cardiol 6:556–563

    PubMed  Google Scholar 

  31. Wohl AJ, Lewis HR, Campbell W, karlsson E, Willerson JT, Mullins CB, Blomquist CG (1977) Cardiovascular function during early recovery from acute myocardial infarction. Circulation 56:931–937

    PubMed  Google Scholar 

  32. Zelis R, Mason DT, Braunwald E (1968) A comparison of the effects of vasodilator stimuli on peripheral resistance vessels in normal subjects and in patients with congestive heart failure. J Clin Invest 47:960–970

    PubMed  Google Scholar 

  33. Zelis R, Delea CS, Coleman HN, Mason DT (1970) Arterial sodium content in experimental congestive heart failure. Circulation 41:213

    PubMed  Google Scholar 

  34. Zelis R, Flaim SF, Moskowitz RM, Nellis SH (1979) How much can we expect from vasodilator therapy in congestive heart failure. Circulation 59:1092–1097

    PubMed  Google Scholar 

  35. Zelis R, Flaim SF (1982) Alterations in vasomotor tone in congestive heart failure. Prog Cardiovasc Dis 24:437–459

    Article  PubMed  Google Scholar 

  36. Zelis R, Longhurst J, Capone RJ, Mason DT (1974) A comparison of regional blood flow and oxygen utilization during dynamic forearm exercise in normal subjects and patients with congestive heart failure. Circulation 50:137–143

    PubMed  Google Scholar 

Download references

Author information

Author notes

  1. H. Drexler

    Present address: Medizinische Klinik III, Hugstetter Str 55, 7800, Freiburg, (F.R.G.)

Authors and Affiliations

  1. Departments of Medicine and Physiology, The Milton S. Hershey Medical Center, The Pennsylvania State University, College of Medicine, 17033, Hershey, Pennsylvania, (U.S.A.)

    H. Drexler, St. F. Flaim, E. J. Toggart, M. R. Glick & R. Zelis

Authors
  1. H. Drexler
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. St. F. Flaim
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. J. Toggart
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. R. Glick
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. R. Zelis
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Helmut Drexler was recipient of a fellowship grant from the Deutsche Forschungsgemeinschaft (DFG)

Edward J. Toggart was supported by the National Heart, Lung and Blood Institute Public Health Service grant No. HL 06239-02

Rights and permissions

Reprints and permissions

About this article

Cite this article

Drexler, H., Flaim, S.F., Toggart, E.J. et al. Cardiocirculatory adjustments to exercise following myocardial infarction in rats. Basic Res Cardiol 81, 350–360 (1986). https://doi.org/10.1007/BF01907456

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01907456

Key words

Search

Navigation