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Genetic control of igG2a production in the response to sheep erythrocytes

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Abstract

A low IgG2a response in B10 mice during the primary response to sheep red blood cells (SRBC) is described. Analysis of the response in B10 × BALB/c hybrid progenies and in congenic strains indicates that this low response is a dominant phenotype placed under the control of a single Mendelian gene or a group of closely linked genes. This gene(s) is neither linked to CH allotypes orH2 haplotypes, nor is it sex-linked. It can be considered as an isotype- and antigenspecific regulatory gene of the immune response.

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Seman, M., Zilberfarb, V., Stanislawski, M. et al. Genetic control of igG2a production in the response to sheep erythrocytes. Immunogenetics 7, 131–139 (1978). https://doi.org/10.1007/BF01843998

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  • DOI: https://doi.org/10.1007/BF01843998

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