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Serum HIV-1 RNA load to predict CD4+ T-cell depletion in asymptomatic patients

Vorhersagewert der Serum-HIV-1 RNA-Last für die CD4+-T-Zell-Depletion bei asymptomatischen Patienten

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Summary

The temporal association between the increase in viral replication and the depletion in CD4+ T cells in HIV-1 infection is not yet clear. To investigate this phenomenon HIV-1 RNA was quantified in several frozen sera from 20 asymptomatic HIV-1 infected patients in the 2 years preceding CD4+ T cell depletion of 50% or more, and compared with 20 HIV-1 infected paired patients who were stable in the same period. In each group, no statistically significant variation in the mean HIV-1 RNA titre was found between the last checkup and the one 24 months earlier. The mean HIV-1 RNA titre was 103.86 copies/ml in the non-progressor group and 105.12 copies/ml in the progressor group. These data support the view that the quantity of circulating HIV-1 RNA is an early predictor of disease progression that is relatively constant during the asymptomatic period of HIV-1 infection.

Zusammenfassung

Die zeitliche Beziehung zwischen der zunehmenden Virusreplikation und Depletion der CD4+ T-Zellen bei HIV-1 Infektion ist noch nicht geklärt. Um dieses Phänomen zu untersuchen, haben wir eine Quantifizierung der HIV-1 RNA in mehreren Seren von 20 asymptomatischen HIV-1 infizierten Patienten durchgeführt, die in den Jahren vor einer Verminderung der CD4+ T-Zellen um 50% und mehr eingefroren worden waren. Die Werte wurden mit denjenigen von 20 HIV-1 infizierten Patientenpaaren verglichen, die während desselben Zeitraums stabil geblieben waren. In keiner der Gruppen fanden sich statistisch signifikante Unterschiede im mittleren HIV-1 RNA-Titer zwischen der Untersuchung zum Zeitpunkt 24 Monate und der ersten Untersuchung. In der nicht progredienten Gruppe fand sich ein mittlerer HIV-1 RNA-Titer von 103,86/ml Kopien, in der progredienten Gruppe 105,12/ml. Diese Ergebnisse sprechen dafür, daß die Menge an zirkulierender HIV-1 RNA ein früher Prädiktor der Krankheitsprogression ist, der während der asymptomatischen Phase der HIV-1 Infektion relativ konstant bleibt.

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Lafeuillade, A., Pellegrino, P., Poggi, C. et al. Serum HIV-1 RNA load to predict CD4+ T-cell depletion in asymptomatic patients. Infection 24, 245–247 (1996). https://doi.org/10.1007/BF01781103

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