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Polyphasic type a hepatitis: Histological features

Histopathologisches Bild der polyphasischen Hepatitis A

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Summary

The histology of polyphasic type A hepatitis was analyzed in liver biopsy specimens of two patients. The microscopic examination showed, together with changes of acute viral hepatitis, portal plasma cell infiltration, limiting plate erosion and porto-portal bridging necrosis. These features, although sometimes described in classical HAV hepatitis, appear to be similar to those commonly observed in severe and evolving forms of acute hepatitis due to other hepatotropic viruses. Only careful serological analyses can lead to a correct diagnosis and prognosis in case of polyphasic type A hepatitis.

Zusammenfassung

Bei zwei Patienten mit polyphasischer Hepatitis A standen Leberbiopsien für die histopathologische Untersuchung zur Verfügung. Neben Veränderungen der akuten Virushepatitis fanden sich portale Plasmazellinfiltrationen, eine Erosion der Endplatte und Brückennekrosen. Diese Veränderungen werden manchmal auch bei der klassischen Hepatitis A beschrieben. Sie ähneln jedoch mehr den Veränderungen, die man bei schweren, fortschreitenden Formen von Infektionen durch andere hepatotrope Viren beobachtet. Nur die sorgfältige serologische Diagnostik kann zu einer korrekten Diagnose und prognostischen Beurteilung der polyphasischen Hepatitis A führen.

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Authors and Affiliations

  1. Dipartimento di Patologia Umana, Università di Messina, Policlinico Universitario Pad. D., Gazzi

    Daniela Villari M. D. & Santina Spinella M. D.

  2. Dipartimento di Medicina Interna, Università di Messina, I-98100, Messina

    G. Raimondo M. D., M. Pernice M. D. & Giuseppina Rodinò M. D.

  3. Istituto di Malattie Infettive, Università di Bologna, I-40100, Bologna, Italy

    L. Attard M. D. & Gabriela Verucchi M. D.

Authors
  1. Daniela Villari M. D.
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  2. Santina Spinella M. D.
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  3. G. Raimondo M. D.
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  4. M. Pernice M. D.
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  5. Giuseppina Rodinò M. D.
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  6. L. Attard M. D.
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  7. Gabriela Verucchi M. D.
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Villari, D., Spinella, S., Raimondo, G. et al. Polyphasic type a hepatitis: Histological features. Infection 21, 46–48 (1993). https://doi.org/10.1007/BF01739313

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  • DOI: https://doi.org/10.1007/BF01739313

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