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Numbers and avidity of anti-DNP antibody plaques in different inbred mouse strains

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Abstract

Spleen cells of mice from eight inbred strains and three F1 hybrids, undergoing a secondary immune response to dinitrophenylated keyhole limpet hemocyanin (DNP-KLH), were examined for numbers of indirect DNP-specific plaque forming cells (PFC) as well as avidity of anti-DNP antibodies. The results indicated that the magnitude of the immune response is under genetic control. Differences in average avidity and heterogeneity of avidity were found among different mouse strains, suggesting genetic control of these parameters. However, no simple pattern of inheritance for these characteristics emerged from the study.

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Minga, U.M., Segre, M. & Segre, D. Numbers and avidity of anti-DNP antibody plaques in different inbred mouse strains. Immunogenetics 2, 369–377 (1975). https://doi.org/10.1007/BF01572306

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  • DOI: https://doi.org/10.1007/BF01572306

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