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The T-Cell factor specific for poly(Tyr, Glu)-Poly(Pro)-Poly(Lys) is an I-Region gene product

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Abstract

The nature of a T-cell factor specific for poly(Tyr,Glu)-poly(Pro)-poly(Lys) [(T,G)-pro-L] was established in the present study. The activity of the (T,G)-Pro-L-specific factor was not removed by anti-mouse immunoglobulin Sepharose columns, suggesting that it is not a classical immunoglobulin. On the other hand, the factor lost its activity after passage through immunoadsorbents prepared with anti-H-2 sera raised against theH-2 haplotypes of the mouse strains in which the factor was prepared. Furthermore, this factor was adsorbed byI region-specific antisera but not by antisera directed against theI-J andI-C subregions as well as theK andD regions of theH-2 complex. Thus, the (T,G)-Pro-L-specific T-cell factor is most probably anI-A subregion gene product.

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Isac, R., Dorf, M. & Mozes, E. The T-Cell factor specific for poly(Tyr, Glu)-Poly(Pro)-Poly(Lys) is an I-Region gene product. Immunogenetics 5, 467–475 (1977). https://doi.org/10.1007/BF01570506

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  • DOI: https://doi.org/10.1007/BF01570506

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