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Cerebral blood flow changes induced by electrical stimulation of the Gasserian ganglion after experimentally induced subarachnoid haemorrhage in pigs

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Summary

The effect of trigeminal electrical stimulation on cerebral blood flow has been studied in conditions of normal or reduced cerebral blood flow (CBF).

Autologous blood was injected into the subarachnoid space of ten Pittmann-Moore pigs to induce subarachnoid haemorrhage (SAH) accompanied by cerebral blood flow (CBF) reduction. One week later, in six of ten animals, a considerable decrease of CBF was noted as evaluated by means of a recording-system monitoring over the right parieto-temporal calvarium the washout of133 Xenon injected into the internal carotid artery after the external carotid had been clamped. Continuous electrical stimulation of the Gasserian ganglion performed in the six animals with severely induced CBF reduction produced a remarkable cerebrovascular dilation and increase of CBF lasting over 3 h.

Electrical stimulation of the Gasserian ganglion produced a similar pattern of vasodilation in six pigs in which no blood was injected and no reduction of CBF was evident.

The mechanisms and the anatomical pathways which underlie these results are discussed.

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References

  1. Bergvall U, Steiner L, Forster DMC (1973) Early pattern of cerebral circulatory disturbances following subarachnoid haemorrhage. Neuroradiology 5: 24–32

    Google Scholar 

  2. Bill A, Stjernschantz J, Mandahl A, Brodin E, Nilsson G (1979) Substance P: release on trigeminal nerve stimulation, effects in the eye. Acta Physiol Scand 106: 371–373

    Google Scholar 

  3. Dawson B, Michenfelder JD, Theye RA (1971) Effects of ketamine on canine cerebral blood flow and metabolism: modification by prior administration of thiopental. Anaesth Analg 50: 443–447

    Google Scholar 

  4. Drummond PD, Gonski A, Lance JW (1983) Facial flushing after thermocoagulation of the Gasserian ganglion. J Neurol Neurosurg Psychiatry 46: 611–616

    Google Scholar 

  5. Fox RH, Goldsmith R, Kidd DJ (1962) Cutaneous vasomotor control in the human head, neck and upper chest. J Physiol 161: 298–312

    Google Scholar 

  6. Goadsby PJ, Edvinsson L, Ekman R (1989) Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system. Ann Neurol 23: 193–196

    Google Scholar 

  7. Gonzalez G, Onofrio BM, Kerr FWL (1975) Vasodilator sytem for the face. J Neurosurg 42: 696–703

    Google Scholar 

  8. Grubb RL Jr, Raicle ME, Eichlins JO, Gado MH (1977) Effects of subarachnoid haemorrhage on cerebral blood volume, blood flow, and oxygen utilization in humans. J Neurosurg 46: 446–453

    Google Scholar 

  9. Hemmingsen R, Hertz MM, Barry DI (1979) The effect of propranolol on cerebral oxygen consumption and blood flow in the rat: measurements during normocapnia and hypercapnia. Acta Physiol Scand 105: 274–281

    Google Scholar 

  10. Jefferson G (1931) Observations on trigeminal neuralgia. Br Med J 2: 879–883

    Google Scholar 

  11. Jennett B, Miller JD, Harper AM (1976) Anatomy of the collateral cerebral circulation in man and animals. In effect of carotid artery surgery on cerebral blood flow. Amsterdam, Excerpta Medica, pp 21–39

    Google Scholar 

  12. Lambert GA, Bogduk N, Goadsby PJ, Duckworth JW, Lance JW (1984) Decreased carotid resistance in cats in response to trigeminal stimulation. J Neurosurg 61: 307–315

    Google Scholar 

  13. Lambert GA, Goadsby PJ, Zagami AS, Duckworth JW (1988) Comparative effects of stimulation of the trigeminal ganglion and the superior sagittal sinus on cerebral blood flow and evoked potentials in the cat. Brain Res 53: 143–149

    Google Scholar 

  14. Lang R, Zimmer R (1974) Neurogenic control of cerebral blood flow. Exp Neurol 43: 143–161

    Google Scholar 

  15. Lembeck F, Holzer P (1979) Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation. Naunyn-Schmiedeberg's Arch Pharmacol 310: 175–183

    Google Scholar 

  16. Liu-Chen LY, Gillespie SA, Norregaard TV, Moskowitz MA (1984) Colocalization of retrogradely transported wheat germ agglutinin and the putative neurotransmitter substance P within trigeminal ganglion cells projecting to cat middle cerebral artery. J Comp Neurol 25: 187–192

    Google Scholar 

  17. Matthews B, Robinson PP (1980) The course of postganglionic sympathetic fibres distributed with trigeminal nerve in cat. J Physiol (London) 303: 391–401

    Google Scholar 

  18. Mayberg MR, Zervas NT, Moskowitz MA (1984) Trigeminal projections to supratentorial pial and dural blood vessels in cats demonstrated by hroseradish peroxidase histochemistry. J Comp Neurol 3: 46–56

    Google Scholar 

  19. McCulloch J, Uddman R, Kingman TA, Edvinsson L (1986) Calcitonin gene related peptide: functional role in cerebrovascular regulation. Proc Natl Acad Sci USA 83: 5731–5735

    Google Scholar 

  20. McCulloch J, Kingman TA, Uddman R, Edvinsson L (1987) The vasomotor significance of the trigemino-cerebrovascular innervation. J Cerebr Blood Flow Metabol [Suppl]1: S225

    Google Scholar 

  21. McCulloch J: Peptidergic innervation of the cerebral vasculature and its functional significance. NATO Advanced Research Workshop, Salo' 3–8 September 1988, 31–33

  22. Michenfelder JD, Theye RA (1971) Effects of fentanyl, droperidol, and innovar on canine cerebral metabolism and blood flow. Br J Anaesth 43: 630–636

    Google Scholar 

  23. Moskowitz MA, Reinhard JF Jr, Romero J, Melamed E, Pettibone DJ (1979) Neurotranmitters and the fifth cranial nerve: is there a relation to the headache phase of migraine? Lancet 2: 883–885

    Google Scholar 

  24. Olesen J, Paulson OB, Lassen NA (1971) Regional cerebral blood flow in man determined by the initial slope of the clearance of intra-arterially injected133 Xenon. Stroke 2: 519–540

    Google Scholar 

  25. Onofrio BM (1975) Radiofrequency percutaneous Gasserian ganglion lesions. Results in 140 patients with trigeminal pain. J Neurosurg 42: 132–139

    Google Scholar 

  26. Petruk KC, West GR, Marriott MR, McIntyre JW, Oreston TR, Weir WKA (1972) Cerebral blood flow following induced subarachnoid haemorrhage in the monkey. J Neurosurg 37:316–324

    Google Scholar 

  27. Rowbotham GF (1939) Observations on the effects of trigeminal denervation. Brain 62: 364–380

    Google Scholar 

  28. Sakas DE, Moskowitz MA, Buzzi MG, Wei EP, Kontos HA, Kano M (1989) Trigeminovascular fibers increase blood flow in cortical grey matter by axon reflex-like mechanisms. J Cereb Blood Flow Metabol [Suppl]1: S31

    Google Scholar 

  29. Siegfried J (1977) 500 Percutaneous Thermocoagulation of the Gasserian ganglion for trigeminal pain. Surg Neurol 8: 126–131

    Google Scholar 

  30. Simmons T, Ruskell GI (1988) Distribution and termination of trigeminal nerves to the cerebral arteries in monkeys. J Anat 159: 57–71

    Google Scholar 

  31. Stattin S (1973) Changes in meningeal and cerebral circulation in subarachnoid haemorrhage. Neuroradiology 5: 20–23

    Google Scholar 

  32. Sweet WH, Wepsic JG (1974) Controlled thermocoagulation of the trigeminal ganglion and rootlets for differential destruction of pain fibers. Part 1: trigeminal neuralgia. J Neurosurg 39:143–156

    Google Scholar 

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Authors and Affiliations

  1. Department of Neurosurgery, University of Padova, Padova, Italy

    G. Salar, I. Iob, G. B. Costella, C. Battaggia & L. Peserico

  2. Department of Anaesthesiology and Intensive Care, University of Padova, Padova, Italy

    C. Ori

Authors
  1. G. Salar
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  2. C. Ori
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  3. I. Iob
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  4. G. B. Costella
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  5. C. Battaggia
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  6. L. Peserico
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Salar, G., Ori, C., Iob, I. et al. Cerebral blood flow changes induced by electrical stimulation of the Gasserian ganglion after experimentally induced subarachnoid haemorrhage in pigs. Acta neurochir 119, 115–120 (1992). https://doi.org/10.1007/BF01541794

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