Skip to main content
SpringerLink
Log in

Does chronic aspirin treatment increase blood pressure in man?

Steigert eine Langzeit-Aspirin-Therapie den Blutdruck beim Menschen

  • Kurze Wissenschaftliche Mitteilungen
  • Published:
Klinische Wochenschrift Aims and scope Submit manuscript

Summary

In postmyocardial infarction patients longterm aspirin treatment with 1.5 g/day led to a significant increase in systolic and diastolic blood pressure after 6 months. This could not be found in the placebo- and the phenprocoumon-treated patients. After one year the blood pressure behaviour was the same in all three treatment groups. As nonsteroidal antirheumatic drugs can produce hypertension in animals, probably due to inhibition of prostaglandin synthesis, blood pressure control in longterm aspirin treatment is advisable.

Zusammenfassung

Nach 6 Monaten Therapie mit 1,5 g Acetylsalizylsäure täglich wurde bei Postinfarkt-Patienten ein signifikanter Anstieg des systolischen und diastolischen Blutdrucks beobachtet. Ein solches Ansteigen des Blutdrucks konnte bei den mit Placebo oder Phenprocoumon Behandelten nicht nachgewiesen werden. Ein Jahr nach Therapiebeginn war das Blutdruckverhalten gleich in allen drei Therapiegruppen. Da auch bei Tieren mit nichtsteroidalen Antirheumatika ein Hochdruck erzeugt werden konnte, wahrscheinlich durch Hemmung der Prostaglandinsynthese, ist die regelmäßige Blutdruckkontrolle während einer Langzeit-Aspirin-Therapie ratsam.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Breddin K (1968) Die Thrombocytenfunktion bei hämorrhagischen Diathesen, Thrombosen und Gefäßkrankheiten. Thromb Diath Haemorrh 27 [Suppl]

  • Breddin K, Überla K, Walter E (1977) German-austrian multicenter two years prospective study on the prevention of secondary myocardial infarction by ASA in comparison to phenprocoumon and placebo. Thromb Haemostas 38 (1):168 (Abstract)

    Google Scholar 

  • Burch JW, Stanford N, Majerus PW (1978) Inhibition of platelet prostaglandin synthetase by oral aspirin. J Clin Invest 61:314–319

    PubMed  Google Scholar 

  • Colina-Chourio J, McGiff JC, Nasjletti A (1975) Development of high blood pressure following inhibition of prostaglandin synthesis. Fed Proc 34:368 (Abstract)

    Google Scholar 

  • Elwood PC, Cochrane AL, Burr ML, Sweetnam PM, Williams G, Welsby E, Hughes SJ, Renton R (1974) A randomized controlled trial of acetyl salicylic acid in the secondary prevention of mortality from myocardial infarction. Br Med J 1:436–440

    PubMed  Google Scholar 

  • Elwood PC, Sweetnam PM (1979) Aspirin and secondary mortality after myocardial infarction. Lancet 2:1313–1315

    PubMed  Google Scholar 

  • Gafni Y, Schwartzman M, Raz A (1978) Prostaglandin biosynthesis in rabbit renal medulla: Inhibition in vitro vs. in vivo by aspirin, indomethacin and meclofenamic acid. Prostaglandins 15:759–772

    PubMed  Google Scholar 

  • Klimt ChR (1978) Results of the coronary drug project aspirin study and design of the aspirin myocardial infarction study and the persantine-aspirin reinfarction study. In: Breddin K, Dorndorf W, Loew D, Marx R Acetylsalicylic acid in cerebral ischemia and coronary heart disease (eds) Schattauer, Stuttgart New York, pp 129–140

    Google Scholar 

  • Lonigro AJ, Itskovitz HD, Crowshaw K, McGiff JC (1973) Dependency of renal blood flow on prostaglandin synthesis in the dog. Circ Res 32:712–717

    PubMed  Google Scholar 

  • Masotti G, Galanti G, Poggesi L, Abbate R, Neri Serneri GG (1979) Differential inhibition of prostacyclin production and platelet aggregation by aspirin. Lancet 2:1213–1216

    PubMed  Google Scholar 

  • McGiff JC (1979) Prostaglandins in circulatory disorders. Triangel 18:101–107

    Google Scholar 

  • Romero JC, Strong CG (1977) The effect of indomethacin blockade of prostaglandin synthesis on blood pressure of normal rabbits and rabbits with renovascular hypertension. Circ Res 40:35–41

    PubMed  Google Scholar 

  • Rosenthal J, Simon PG, Silbergleit A (1974) Effects of prostaglandin deficiency on natriuresis, diuresis, and blood pressure. Prostaglandins 5:435–440

    PubMed  Google Scholar 

  • The Coronary Drug Project (CDP) Research Group (1976) Aspirin in coronary heart disease. J Chron Dis 29:625–642

    Google Scholar 

  • The Persantine-Aspirin Reinfarction Study (PARIS) Research Group (1980) Persantine and aspirin in coronary heart disease. Circulation 62:449–461

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medical Department of the University of Heidelberg, Germany

    E. Walter, W. Kaufmann & P. Oster

Authors
  1. E. Walter
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. Kaufmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. Oster
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Walter, E., Kaufmann, W. & Oster, P. Does chronic aspirin treatment increase blood pressure in man?. Klin Wochenschr 59, 297–299 (1981). https://doi.org/10.1007/BF01478209

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01478209

Key words

Schlüsselwörter

Search

Navigation