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Immunomodulators interfere with angiopathy but not vasospasm after subarachnoid haemorrhage in rabbits

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Summary

The present study deals with the effects of immunomodulators on the morphology of intracerebral arterial walls in rabbits with experimental subarachnoid haemorrhage (SAH). Immunostimulators: thymostimuline and inosine dimethylamino-isopropanol-p-acetamido-benzoate were found to aggravate the angiopathic changes, whereas immunosuppressive drugs — cyclosporine A and azathioprine appeared to prevent the damage. The authors consider the possibility of using immunosuppressive drugs in patients with ruptured intracranial aneurysms.

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Authors and Affiliations

  1. Department of Neurophysiology, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

    M. Ryba M. D., Ph. D.

  2. Laboratory of Ultrastructure of Central Nervous System, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

    M. Walski

  3. Department of Anaesthesiology and Intensive Care Medicine, Medical School, Warsaw, Poland

    K. Iwanska

  4. Department of Neurosurgery, Institute of Surgery, Medical School, Warsaw, Poland

    M. Pastuszko

Authors
  1. M. Ryba M. D., Ph. D.
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  2. K. Iwanska
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  3. M. Walski
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  4. M. Pastuszko
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Ryba, M., Iwanska, K., Walski, M. et al. Immunomodulators interfere with angiopathy but not vasospasm after subarachnoid haemorrhage in rabbits. Acta neurochir 108, 81–84 (1991). https://doi.org/10.1007/BF01407672

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  • DOI: https://doi.org/10.1007/BF01407672

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