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Treatment of craniopharyngiomas—the stereotactic approach in a ten to twenty-three years' perspective

II. Psychosocial situation and pituitary function

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Summary

Fourty-two consecutive patients with craniopharyngioma were treated by “stereotactic approach”, i.e. preferentially stereotactic puncture and installation of colloid isotope into cystic tumours and external stereotactic single dose irradiation to solid tumour parts. In a minority of cases, such treatment was less suitable, and surgical removal and/or radiotherapy was used. There was no peroperative mortality. A long-term follow up (observation time 10–23 years) of the 31 patients alive indicated that they were socially well adapted with a high rate of fulltime work and a low rate of intercurrent disease. In spite of substitution therapy for pituitary insufficiency in most cases, the patients were subjectively seldom disturbed by their disease.

Our results support a change in the choice of therapy for craniopharyngioma patients, from open neurosurgery to the less invasive stereotactic techniques.

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References

  1. Amendola BE, Gebarski SS, Bermudez AG (1985) Analysis of treatment results in craniopharyngioma. J Clin Oncol 3: 252–258

    PubMed  Google Scholar 

  2. Andler W, Roosen K, Clar HE (1979) Pre- and postoperative evaluation of hypothalamo-pituitary function in children with cranio-pharyngiomas. Acta Neurochir (Wien) 45: 287–299

    Google Scholar 

  3. Arem R, Zoghbi W, Chan L (1983) Amenorrhea-galactorrhea and craniopharyngioma. Surg Neurol 20: 109–112

    Article  PubMed  Google Scholar 

  4. Backlund E-O, Johansson L, Sarby B (1972) Studies on craniopharyngiomas II. Treatment by stereotaxis and radiosurgery. Acta Chir Scand 138: 749–759

    PubMed  Google Scholar 

  5. Backlund E-O (1973a) Studies on craniopharyngiomas III. Stereotaxic treatment with intracystic yttrium-90. Acta Chir Scand 139: 237–247

    PubMed  Google Scholar 

  6. Backlund E-O (1973b) Studies on craniopharyngiomas IV. Stereotaxic treatment with radiosurgery. Acta Chir Scand 139: 344–351

    PubMed  Google Scholar 

  7. Backlund E-O, Axelsson B, Bergstrand C-G, Eriksson A-L, Norén G, Ribbesjö E, Rähn T, Schnell P-O, Tallstedt L, Sääf M, Thorén M (1989) Treatment of craniopharyngiomas—the stereotactic approach in a ten to twenty-three years perspective. I. Surgical, radiological and ophthalmological aspects. Acta Neurochir (Wien) 99: 11–19

    Google Scholar 

  8. Bloom HJG (1975) Combined modality therapy for intracranial tumors. Cancer 35: 111–120

    PubMed  Google Scholar 

  9. Carmel PW, Antunes JL, Chang CH (1981) Craniopharyngiomas in children. Neurosurgery 11: 382–389

    Google Scholar 

  10. Cavazutti V, Fischer EG, Welch K, Belli JA, Winston KR (1983) Neurological and psychophysiological sequelae following treatment of craniopharyngioma in children. J Neurosurg 59: 409–417

    PubMed  Google Scholar 

  11. Clopper RR, Meyer WJ, Udvarhelyi GB, Money J, Aarabi B, Mulvihill JJ, Piasio M (1977) Postsurgical IQ and behavioral data on twenty patients with a history of childhood craniopharyngioma. Psychoneuroendocrinol 2: 365–377

    Google Scholar 

  12. Danoff BF, Cowchock FS, Kramer S (1983) Childhood craniopharyngioma: survival, local control, endochrine and neurologic function following radiotherapy. Int J Radiat Oncol Biol Phys 9: 171–175

    PubMed  Google Scholar 

  13. Fischer EG, Welch K, Belli AJet al (1985) Treatment of craniopharyngioma in children 1972–1981. J Neurosurg 62: 496–501

    PubMed  Google Scholar 

  14. Flick TH, Michel M (1986) Rehabilitation jugendlicher Kraniopharyngeom-Patienten. Rehabilitation 25: 45–52

    PubMed  Google Scholar 

  15. Franks S, Nabarro IDN, Jacobs HS (1977) Prevalence and presentation of hyperprolactinemia in patients with “functionless” pituitary tumours. Lancet i: 778–780

    Google Scholar 

  16. Galatzer A, Nofar E, Beit-Halachmi N, Aran O, Shalit M, Roitman A, Laron Z (1981) Intellectual and psychosocial functions in children, adolescents and young adults before and after operation for craniopharyngioma. Child Care Health Dev 7: 307–316

    PubMed  Google Scholar 

  17. Galatzer A, Aran O, Beit-Halachmi N, Nofar E, Rubitchek J, Pertzelan A, Laron Z (1987) The impact of long-term therapy by a multi-disciplinary team on the education, occupation and marital status of growth hormone deficient patients after termination of therapy. Clin Endocrinol 27: 191–196

    Google Scholar 

  18. Grant DB, Lyen K (1982) Hypopituitarism after surgery for craniopharyngioma. Child's Brain 9: 201–204

    PubMed  Google Scholar 

  19. Hoffman HJ, Hendrick EB, Humphreys RP, Buncic JR, Armstrong DL, Jenkin RDT (1977) Management of craniopharyngioma in children. J Neurosurg 47: 218–227

    PubMed  Google Scholar 

  20. Hoffman HJ (1985) Craniopharyngiomas. Can J Neurol Sci 12: 348–352

    PubMed  Google Scholar 

  21. Hoffman HJ (1987) Craniopharyngiomas. Prog Exp Tumor Res 30: 325–334

    PubMed  Google Scholar 

  22. Kahn EA, Goscg HH, Seeger JF, Hicks SP (1973) Forty-five years of experience with the craniopharyngiomas. Surg Neurol 1: 5–12

    PubMed  Google Scholar 

  23. Katz EL (1975) Late results of radical excision of craniopharyngiomas in children. J Neurosurg 42: 86–90

    PubMed  Google Scholar 

  24. Keraly JL, Aubier F, Derome P, Kalifa CH, Lemerle J, Canlorbe P, Chaussain JL, Job JC (1986) Evolution à moyen terme des craniopharyngiomes de l'enfant en fonction des choix thérapeutiques initiaux. Arch Fr Pédiatr 43: 593–599

    Google Scholar 

  25. Kobayashi T, Kageyama N, Ohara K (1981) Internal irradiation for cystic craniopharyngioma. J Neurosurg 55: 896–903

    PubMed  Google Scholar 

  26. Kuskowska-Wolk A, Rössner S (Submitted 1989) Prevalence of obesity in Sweden. Cross-sectional study of a representative adult population. Acta Med Scand

  27. Lapras C, Patet JD, Mottolese C, Gharbi S, Lapras Ch (1987) Craniopharyngiomas in childhood: analysis of 42 cases. Prog Exp Tumor Res 30: 350–358

    PubMed  Google Scholar 

  28. Leksell L, Lidén K (1952) A therapeutic trial with radioactive isotopes in cystic brain tumour. In: Radioisotope techniques. Vol 1, Medical and physiological applications, H. M. Stationery Office, Oxford, pp 1–4

    Google Scholar 

  29. Leksell L, Backlund E-O, Johansson L (1967) Treatment of craniopharyngiomas. Acta Chir Scand 133: 345–350

    PubMed  Google Scholar 

  30. Lindqvist G (1966) Mental changes after transsphenoidal hypophysectomy. Acta Phys Scand 42: Supplement 190

  31. Lundberg PO, Osterman PO, Wide L (1981) Serum prolactin in patients with hypothalamus and pituitary disorders. J Neurosurg 55: 194–199

    PubMed  Google Scholar 

  32. Lyen KR, Grant DB (1982) Endocrine function, morbidity and mortality after surgery for craniopharyngioma. Arch Dis Child 57: 837–841

    PubMed  Google Scholar 

  33. Matson DD (1964) Craniopharyngioma. Clin Neurosurg 10: 116–129

    PubMed  Google Scholar 

  34. Matson DD, Crigler Jr JF (1969) Management of craniopharyngioma of childhood. J Neurosurg 30: 377–390

    PubMed  Google Scholar 

  35. Mori K, Handa H, Murata T, Takeuchi T, Miwa S, Osaka K (1980) Results of treatment of craniopharyngioma. Childs Brain 6: 303–312

    PubMed  Google Scholar 

  36. OECD: Employment Outlook September 1985

  37. Petito CK, de Girolami U, Earle KM (1976) Craniopharyngiomas: a clinical and pathological review. Cancer 37: 1944–1952

    PubMed  Google Scholar 

  38. Sveriges officiella Statistik. Statistiska Centralbyrån, Stockholm (1985). Trender och prognoser inför 90-talet

  39. Shillito J (1986) Treatment of craniopharyngioma. Clin Neurosurg 33: 533–546

    PubMed  Google Scholar 

  40. Sorva R, Heiskanen O (1986) Craniopharyngioma in Finland. A study of 123 cases. Acta Neurochir (Wien) 81: 85–89

    Google Scholar 

  41. Sorva R, Jääskinen J, Heiskanen O, Perheentupa J (1988) Postoperative computed tomographic control of 38 patients with craniopharyngioma. Surg Neurol 29: 115–119

    PubMed  Google Scholar 

  42. Stahnke N, Grubel G, Lagenstein I, Willig RP (1984) Longterm follow-up of children with craniopharyngioma. Eur J Pediatr 142: 179–185

    PubMed  Google Scholar 

  43. Stelling MW, McKay SE, Carr WA, Walsh JW, Baumann RJ (1986) Frontal lobe lesions and cognitive function in craniopharyngioma survivors. AJDC 140: 710–714

    PubMed  Google Scholar 

  44. Svolos DG (1969) Craniopharyngiomas: a study based on 108 verified cases. Acta Chir Scand [Suppl] 403: 1–44

    Google Scholar 

  45. Sweet WG (1976) Radical surgical treatment of craniopharyngiomas. Clin Neurosurg 23: 52–79

    PubMed  Google Scholar 

  46. Sweet WH (1980) Recurrent craniopharyngiomas: therapeutic alternatives. Clin Neurosurg 27: 206–229

    PubMed  Google Scholar 

  47. Symon L, Sprich W (1985) Radical excision of craniopharyngioma. Results in 20 patients. J Neurosurg 62: 174–181

    PubMed  Google Scholar 

  48. Thomsett MJ, Conte FA, Kaplan SL, Grumbach MM (1980) Endocrine and neurologic outcome in childhood craniopharyngioma: Review of effect of treatment in 42 patients. J Pediatr 97: 728–735

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Endocrinology, Karolinska Hospital, Stockholm, Sweden

    M. Sääf & M. Thorén

  2. Department of Neurosurgery, Karolinska Hospital, Stockholm, Sweden

    G. Norén & T. Rähn

  3. Department of Ophthalmology, Karolinska Hospital, Stockholm, Sweden

    L. Tallstedt

  4. Department of Neuroradiology, Karolinska Hospital, Stockholm, Sweden

    C. -G. Bergstrand

  5. Department of Neurosurgery, University of Bergen, School of Medicine, Haukeland Sykehus, Bergen, Norway

    E. -O. Backlund

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  1. M. Sääf
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  3. C. -G. Bergstrand
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  6. L. Tallstedt
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  7. E. -O. Backlund
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Sääf, M., Thorén, M., Bergstrand, C.G. et al. Treatment of craniopharyngiomas—the stereotactic approach in a ten to twenty-three years' perspective. Acta neurochir 99, 97–103 (1989). https://doi.org/10.1007/BF01402315

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