Abstract
The frequency of hereditary nonpolyposis colorectal cancer was evaluated in a group of colorectal cancer patients under age 50 diagnosed in southern Alberta between 1973 and 1987. Families were identified as positive for this syndrome if three-first-degree relatives in the kindred had colorectal cancer. Of the 390 patients with adenocarcinoma, 318 patients participated. The frequency of hereditary nonpolyposis colorectal cancer was 3.1% (12 families) in this group (Ci95 1.6–5.3%). Clinical characteristics reported on from the index patients include tumor location, Dukes stage at presentation, frequency of synchronous and metachronous tumors, frequency of second primaries, and survival. The 5- and 10-year actuarial survival was 86% and 69%, respectively.
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This work was supported by grants from Alberta Cancer Board and Foothills Hospital Foundation.
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Westlake, P.J., Bryant, H.E., Huchcroft, S.A. et al. Frequency of hereditary nonpolyposis colorectal cancer in southern Alberta. Digest Dis Sci 36, 1441–1447 (1991). https://doi.org/10.1007/BF01296813
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DOI: https://doi.org/10.1007/BF01296813