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The bioavailability of sixteen tetracycline products

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Abstract

Tests were conducted on the relative bioavailability of single lots of 16 different 250-mg tetracycline hydrochloride or tetracycline phosphate complex capsule products commercially available in the United States. All products met the specifications of the Food and Drug Administration for antibiotic certification. Complete crossover studies were carried out with each of the 16 products administered to 16 human volunteers over a period of 16 weeks. The urinary excretion of the tetracycline was followed for 72 hr after the single dose administration. No statistically significant differences were observed, in the cumulative percent of tetracycline excreted, between any of the products or any of the subjects employed in the study.

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Authors and Affiliations

  1. Division of Drug Metabolism and Biopharmaceutics, Department of Medical Chemistry, College of Pharmacy, University of Tennessee Medical Units, 38163, Memphis, Tennessee

    M. C. Meyer & G. W. A. Slywka

  2. Research and Development, Norwich Pharmacal Company, P.O. Box 191, 13815, Norwich, New York

    R. E. Dann

  3. Department of Molecular and Quantum Biology, College of Pharmacy, University of Tennessee Medical Units, 38163, Memphis, Tennessee

    P. L. Whyatt

Authors
  1. M. C. Meyer
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  2. R. E. Dann
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  3. P. L. Whyatt
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  4. G. W. A. Slywka
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Additional information

Supported in part by a Contract from the Tennessee Department of Public Health and by USPHS Grant HL-09495.

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Meyer, M.C., Dann, R.E., Whyatt, P.L. et al. The bioavailability of sixteen tetracycline products. Journal of Pharmacokinetics and Biopharmaceutics 2, 287–297 (1974). https://doi.org/10.1007/BF01061403

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  • DOI: https://doi.org/10.1007/BF01061403

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