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Evidence that monoclonal antibody production kinetics is related to the integral of the viable cells curve in batch systems

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Summary

Monoclonal antibody production kinetics in batch systems is linearly related to the integral of the viable cells curve. This favors the secretion theory over that of release by dead cells. Regression of the production curve over the integral of the viable cells curve in different media can also give information on the nutritional requirements of the cells for growth and production.

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Authors and Affiliations

  1. Microbiology and Fermentation Research Unit Department of Biotechnology, Roussel-Uclaf, 93230, Romainville, France

    J. M. Renard, R. Spagnoli & C. Mazier

  2. Laboratoires Cassenne, 95520, Osny, France

    M. F. Salles & E. Mandine

Authors
  1. J. M. Renard
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  2. R. Spagnoli
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  3. C. Mazier
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  4. M. F. Salles
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  5. E. Mandine
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Renard, J.M., Spagnoli, R., Mazier, C. et al. Evidence that monoclonal antibody production kinetics is related to the integral of the viable cells curve in batch systems. Biotechnol Lett 10, 91–96 (1988). https://doi.org/10.1007/BF01024632

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  • DOI: https://doi.org/10.1007/BF01024632

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