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Isolation of spontaneous Streptomyces hygros copicus 111-81 phosphate-deregulated mutants hyperproducing its antibiotic complex

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Summary

Spontaneous phosphate-deregulated mutants were isolated fromStreptomyces hygroscopicus 111-81, a producer of a nonpolyenic macrolide antibiotic complex. Six of the mutants had stable increased antifungal activity. The activities of the remaining ones were unstable, the same or only slightly higher than that of the initial strain. The most productive mutants had morphological features similar to the parent culture.

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Authors and Affiliations

  1. Institute of Microbiology, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria

    Victoria Gesheva

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  1. Victoria Gesheva
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Gesheva, V. Isolation of spontaneous Streptomyces hygros copicus 111-81 phosphate-deregulated mutants hyperproducing its antibiotic complex. Biotechnol Lett 16, 443–448 (1994). https://doi.org/10.1007/BF01023323

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  • DOI: https://doi.org/10.1007/BF01023323

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