Abstract
Changes in the ultrastructure of motor endings under the influence of the cholinesterase inhibitor arminΔ (5·10−7 g/ml) at rest and during electrical stimulation of the nerve were studied in preparations of the rat phrenic nerve and diaphragm. At rest, armin was found to cause ultrastructural disturbances of the endings similar to those arising in the control during nerve stimulation. Electrical stimulation in the presence of armin caused no further changes in the ultrastructure of the neuromuscular junction. The results indicate the important role of disturbances of the function of the presynaptic apparatus in the mechanisms of the blocking action of armin on neuromuscular conduction.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
S. N. Golikov and V. I. Sanotskii, in: Abstracts of Proceedings of the Fourth All-Union Congress of Pharmacologists [in Russian], Leningrad (1976), pp. 48–49.
A. F. Danilov and A. I. Sklyarov,Fiziol. Zh. SSSR, No. 9, 1310 (1976).
D. P. Matyushkin, Usp. Fiziol. Nauk, No. 3, 28 (1977).
V. V. Fedorov, Usp. Fiziol. Nauk., No. 3, 399 (1977).
E. Bülbring, Br. J. Pharmacol.,1, 38 (1946).
J. E. Heuser and T. S. Reese, J. Cell Biol.,57, 315 (1973).
J. J. Hubbard, R. F. Smidt, and J. Yokota, J. Physiol. (London),181, 810 (1965).
B. Katz and R. Miledi, Proc. R. Soc. B,196, 59 (1977).
H. Kornelissen, Z. Zellforsch.,130, 28 (1972).
M. B. Laskowski and W.-D. Dettbarn, J. Pharmacol. Exp. Ther.,194, 351 (1975).
M. B. Laskowski, W. H. Olsen, and W.-D. Dettbarn, Exp. Neurol.,47, 290 (1975).
M. B. Laskowski, W. H. Olsen, and W.-D. Dettbarn, Exp. Neurol.,57, 13 (1977).
A. Parducz, F. Joo, and O. Feher, J. Neural Transmiss., Suppl. II, 299 (1974).
H.-J. Preuser, Z. Zellforsch.,80, 436 (1967).
T. Santa, A. G. Engel, and E. H. Lambert, Neurology (Minneapolis),22, 71 (1972).
B. Scillik and S. Bense, Acta Biol. Acad. Sci. Hung.,22, 131 (1971).
B. Stamenovic, Naučno-Technic. Pregl.,25, 3 (1975).
J. Villegas, J. Physiol. (London),249, 679 (1975).
Author information
Authors and Affiliations
Additional information
Leningrad. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 88, No. 7, pp. 95–99, July, 1979.
Rights and permissions
About this article
Cite this article
Golikov, S.N., Barantsevich, R.P., Kuznetsov, V.G. et al. Effect of armin on the ultrastructure of the neuromuscular synapse. Bull Exp Biol Med 88, 784–788 (1979). https://doi.org/10.1007/BF00804795
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00804795