Abstract
A method to determine the composition and hydration state of the complexes formed in aqueous solution by cyclodextrins (CD) is presented and applied to the β-CD/ketoprofen system; it is based on a combination of spectroscopic, calorimetric, and thermogravimetric analyses. The complexes have, on average and per β-CD mole, more than eleven water molecules, which are present in completely different bound states.
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Marini, A., Berbenni, V., Bruni, G. et al. Thermoanalytical and spectroscopic characterization ofβ-cyclodextrin/ketoprofen inclusion complexes. J Incl Phenom Macrocycl Chem 22, 221–234 (1995). https://doi.org/10.1007/BF00707085
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DOI: https://doi.org/10.1007/BF00707085