Abstract
Four polylactides, P-L-LAs 100 KD, 240 KD, 500 KD and a P-DL-LA 400 KD, were testedin vitro by using five cell types. Middle ear, ear canal and nasal septum epithelial cells were used as well as fibroblasts and osteosarcoma cells. The proliferation of cells was studied by culturing on polylactide films and by culturing with media based on artificially aged PLA. The fibroblasts and the osteosarcoma cells were also cultured with media containingL- orD-monomers in different concentrations. Significant differences in cell numbers of polylactide cultures and/or controls were observed. These differences varied per cell type and experimental setting. In general the biocompatibility of the PLAs was satisfactory. Some inhibitory effect on the proliferation of high (10 mg ml−1) monomer concentrations in culture media was seen.
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van Sliedregt, A., Radder, A.M., de Groot, K. et al. In vitro biocompatibility testing of polylactides Part I Proliferation of different cell types. J Mater Sci: Mater Med 3, 365–370 (1992). https://doi.org/10.1007/BF00705369
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DOI: https://doi.org/10.1007/BF00705369