Summary
Massive intracerebral hemorrhage developed during open heart surgery on a normotensive patient. This type of hemorrhage ia a rare complication in such surgical procedures. The clinical and pathological findings suggest that drug-induced hypertension, systemic heparinization, and preexisting cerebrovascular damage are associated with the pathogenesis of the lesion.
References
Aguilar, M. J., Gerbode, F., Hill, J. D.: Neuropathologic complications of cardiac surgery. J. thorac. cardiovasc. Surg.61, 676–685 (1971).
Barron, K. D., Fergusson, G.: Intracranial hemorrhage as a complication of anticoagulant therapy. Neurology (Minneap.)9, 447–455 (1959).
Bjork, V. O., Hultquist, G.: Brain damage in children after deep hypothermia for open-heart surgery. Thorax15, 284–291 (1960).
Brierley, J. B.: Neuropathological findings in patients dying after open-heart surgery. Thorax18, 291–304 (1963).
Englund, G. W., Neubuerger, K. T., Minckler, J.: Neuropathologic findings in patients dying following cardiac surgery. In: F. Lüthy and A. Bischoff, ed. Proc. 5th Internat. Cong. Neuropath. Excerpta Medica, Amsterdam 1966, pp. 309–317.
Ehrenhaft, J. L., Claman, M. A., Layton, J. M., Zimmernman, G. R.: Cerebral complications of open-heart surgery: further observations. J. thorac. cardiovasc. Surg.42, 514–526 (1961).
Gilman, S.: Cerebral disorders after open-heart operations. New Engl. J. Med.272, 489–498 (1965).
Russell, D. S.: The pathology of spontaneous intracranial hemorrhage. Proc. roy. Soc. Med.47, 689–693 (1954).
Silverstein, A., Krieger, H. P.: Neurologic complications of cardiac surgery. Arch. Neurol. (Chic.)3, 601–605 (1960).
Tufo, H. M., Ostfeld, A. M., Shekelle, R.: Central nervous system dysfunction following open-heart surgery. J. Amer. med. Ass.212, 1333–1340 (1970).
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Post-doctoral fellow in neuropathology supportedby NIH fellowship 6 FO2 GM 52675
Dr. Gold is presently a neurosurgery resident in the St. Louis University Hospitals
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Nelson, J.S., Case, M.E.S. & Gold, J. Extensive intracerebral hemorrhage during open-heart surgery. Acta Neuropathol 25, 163–165 (1973). https://doi.org/10.1007/BF00687561
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DOI: https://doi.org/10.1007/BF00687561