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Cyclodextrin polymers in the pharmaceutical industry

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Abstract

The potential applications of cyclodextrin polymers (soluble and insoluble ones) in the pharmaceutical industry are reviewed. The soluble polymers are good solubilizers of drugs thus enhancing their bioavailability. When applied topically the insoluble bead polymer accelerates the healing of burns and ulcers. It can also be used for chromatography and to remove certain components from mixtures. The insoluble ground polymer is an effective tablet disintegrant in direct compression systems as well as in formulations made by wet granulation.

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References

  1. J. Szejtli:Cyclodextrin Technology, Kluwer Academic Publishers, 1988.

  2. É. Fenyvesi, M. Szilasi, B. Zsadon, J. Szejtli, and F. Tüdös:Proc. 1st. Int. Symp. on Cyclodextrins, ed.: J. Szejtli, D. Reidel Publ., Dordrecht, p. 345 (1981).

    Google Scholar 

  3. J. Szemán, H. Ueda, J. Szejtli, É. Fenyvesi, Y. Machida, and T. Nagai:Chem. Pharm. Bull. 35 (1987) 282.

    Google Scholar 

  4. K. Uekama, M. Otagiri, T. Irie, H. Seo, and M. Tsuruoka:Int. J. Pharm. 23 (1985) 35.

    Google Scholar 

  5. J. Pitha and J. Pitha:J. Pharm. Sci. 75 (1986) 165.

    Google Scholar 

  6. A. Harada, M. Furue, and S. Nozakura:Polymer J. 13 (1981) 777.

    Google Scholar 

  7. J. Szemán, H. Ueda, J. Szejtli, É. Fenyvesi, Y. Watanabe, Y. Machida, and T. Nagai:Drug Design and Delivery 1 (1987) 325.

    Google Scholar 

  8. J. Pitha, S. M. Harman, and M. E. Mitchel:J. Pharm. Sci. 75 (1986) 165.

    Google Scholar 

  9. Y. Kaji, K. Uekama, H. Yoshikama, K. Takada, and S. Muranishi:Int. J. Pharm. 24 (1985) 79.

    Google Scholar 

  10. K. Karadake, T. Morimoto, and K. Tsuda:Japan Kokai 57-130914 (1982).

  11. I. Jodal: Unpublished results.

  12. G. Arturson, L. Hakelius, S. Jacobsson, and U. Rothman:Burns 4 (1978) 225.

    Google Scholar 

  13. A. Gerloczy, T. Neumark, É. Fenyvesi, and J. Szejtli:Tissue Compatibility of Cyclodextrin Bead Polymer in Rats, in press.

  14. I. Felméray: unpublished results (1985).

  15. B. Zsadon, M. Szilasi, L. Décsei, A. Ujházi, and J. Szejtli:J. Chromatogr. 356 (1986) 428.

    Google Scholar 

  16. B. Zsadon, L. Décsei, M. Szilasi, F. Tüdös, and J. Szejtli:J. Chromatogr. 270 (1983) 127.

    Google Scholar 

  17. P. E. Shaw and C. W. Wilson:J. Food Sci. 50 (1985) 1205.

    Google Scholar 

  18. M. Specht, M. Rothe, L. Szente, and J. Szejtli:Ger. (East) Patent 147,615 (1981).

    Google Scholar 

  19. R. B. Friedman, D. J. Gottneid, D. J. Mauro, and R. L. Owen: 19th ACS National Meeting, Div. Carbohydrate Chem., Chicago (1985).

  20. É. Fenyvesi, O. Shirakura, J. Szejtli, and T. Nagai:Chem. Pharm. Bull. 32 (1984) 665.

    Google Scholar 

  21. É. Fenyvesi, K. Takayama, J. Szejtli, and T. Nagai:Chem. Pharm. Bull. 32 (1984) 670.

    Google Scholar 

  22. É. Fenyvesi and B. Antal: Unpublished results (1987).

  23. É. Fenyvesi, T. Nagai, B. Antal, B. Zsadon, and J. Szejtli:J. Incl. Phenom. 2 (1984) 645.

    Google Scholar 

  24. A. Gerlóczy, A. Fónagy, É. Fenyvesi, and J. Szejtli:Carbohydr. Polym. 5 (1985) 343.

    Google Scholar 

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Fenyvesi, É. Cyclodextrin polymers in the pharmaceutical industry. Journal of Inclusion Phenomena 6, 537–545 (1988). https://doi.org/10.1007/BF00660751

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