Summary
The cellular infiltrate in the dermis of incipient psoriatic lesions was qualitatively and quantitatively evaluated using cytochemical methods for the differentiation of inflammatory cells. The greatest intensity of the dermal infiltrate was always in the center of early lesions. It was shown that most of the inflammatory cells within the perivascular areas of the upper dermis were macrophages, monocytes and lymphocytes. The number of mast cells was not increased; eosinophils and plasma cells could not be detected. Only seldom could a single or a few polymorphonuclear leucocytes be seen in lesions at a more advanced stage. These findings are discussed in the light of known immunological and functional mechanisms.
Zusammenfassung
Das celluläre Infiltrat in der Dermis von Läsionen mit initialer Psoriasis wurde qualitativ cytochemisch zur Differenzierung der Entzündungszellen untersucht. Die größte Dichte des dermalen Infiltrates fand sich immer im Zentrum von frühen Läsionen. Es wurde nachgewiesen, daß die meisten Entzündungszellen innerhalb der perivasculären Räume im oberen Corium Makrophagen, Monocyten und Lymphocyten darstellen. Die Zahl der Mastzellen war nicht erhöht, eosinophile Granulocyten und Plasmazellen konnten nicht nachgewiesen werden. Nur selten fanden sich vereinzelte polymorphkernige Leukocyten in fortgeschrittenem Stadium. Diese Befunde werden von funktionellen und immunologischen Gesichtspunkten diskutiert.
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Supported by the Deutsche Forschungsgemeinschaft
We wish to express our gratitude to Dr. Scherer for assisting in the immunological interpretation of our findings, and to Fräulein Ebmeyer for her qualified technical assistance
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Braun-Falco, O., Schmoeckel, C. The dermal inflammatory reaction in initial psoriatic lesions. Arch. Derm. Res. 258, 9–16 (1977). https://doi.org/10.1007/BF00582862
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DOI: https://doi.org/10.1007/BF00582862