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Effects of adrenergic stimulating and blocking agents on the eccrine sweat secretion in atopic dermatitis and psoriasis

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Summary

Quantitative measurements of eccrine sweat secretion following stimulation with adrenaline and terbutaline sulphate, aβ-stimulator, have been performed in patients with atopic dermatitis and psoriasis by means of the electrolytic water analyzer, “Meeco”. Seasonal variations were demonstrated, the values being lower in the late autumn. The response to adrenaline could be blocked by phentolamine, an α-inhibitor, while propranolol, aβ-inhibitor, had no effect.—The response to terbutaline was blocked by atropine and partly by practolol, aβ-inhibitor. Terbutaline induced a larger sweat response than isoprenaline, anotherβ-stimulator. Aβ-receptor mechanism, in some way related to cholinergic receptors, is suggested.

Zusammenfassung

Die ekkrine Schweißabgabe nach intradermaler Infektion von Adrenalin und Terbutalin sulfat, einemβ-Stimulator, wurde mittels des elektrolytischen Wasser-Analysators „Meeco“ quantitativ gemessen. Saison-abhängige Variationen wurden festgestellt, wobei eine signifikante Verminderung im Herbst beobachtet wurde. Die adrenalininduzierte Schweißabgabe wurde mittels Phentolamin, einem α-Inhibitor, aber nicht mittels Propranolol, einemβ-Inhibitor, blockiert. — Das Terbutalin-induzierte Schwitzen wurde durch Atropin eindeutig, aber durch Practolol, einβ-Inhibitor, nur teilweise blockiert. Terbutalin induzierte eine größere Schweißaktivität als Isoprenalin, ein andererβ-Stimulator. Die Resultate deuten auf einenβ-Receptoren-Mechanismus in den ekkrinen Schweißdrüsen hin, der vielleicht in engem Zusammenhang mit cholinergischen Receptoren steht.

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Authors and Affiliations

  1. Department of Dermatology Rikshospitalet, University of Oslo, Oslo, Norway

    P. Thune & M. Kocsis

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  1. P. Thune
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  2. M. Kocsis
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Thune, P., Kocsis, M. Effects of adrenergic stimulating and blocking agents on the eccrine sweat secretion in atopic dermatitis and psoriasis. Arch. Derm. Res. 253, 97–103 (1975). https://doi.org/10.1007/BF00582061

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