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Disposition of placentally transferred carbamazepine (Tegretol®) in the newborn

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Summary

The plasma elimination of carbamazepine (Tegretol®) was studied in five newborns who had got the drug transplacentally from their epileptic mothers. The half-lives ranged from 8.2 – 27.7 hours which is comparable or even shorter than those found in adults after a single oral dose, but in the same range as those found in adults after multiple oral doses. This suggests that the newborns' drug metabolizing capacity has been induced during fetal life.

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References

  1. West, J.R., Smith, H.W., Chasis, H.: Glomerular filtration rate, effective renal blood flow, and maximal tubular excretory capacity in infancy. J. Pediat.32 10–18 (1948)

    Google Scholar 

  2. Axline, S.G., Yaffe, S.J., Simon, H.J.: Clinical pharmacology of antimicrobials in premature infants. Pediatrics39 97–107 (1967)

    Google Scholar 

  3. Weiss, C.F., Glazko, A.J., Weston, J.K.: Chloramfenicol in the newborn infant. New. Engl. J. Med.262 787–794 (1960)

    Google Scholar 

  4. Gladtke, E.: Pharmacokinetic studies on phenylbutazone in children. Il Farmaco23 897–906 (1968)

    Google Scholar 

  5. Krauer, B., Draffan, G.H., Williams, F.M., Clare, R.A., Dollery, C.T., Hawkins, D.F.: Elimination kinetics of amobarbital in mothers and their newborn infants. Clin. Pharmacol. Ther.14 442–447 (1973)

    Google Scholar 

  6. Jalling, B., Boréus, L.O., Rane, A., Sjöqvist, F.: Plasma concentrations of diphenylhydantoin in young infants. Pharmacol. Clin.2 200–202 (1970)

    Google Scholar 

  7. Rane, A., Borga, O., Garle, M., Sjöqvist, F.: Plasma disappearance of transplacentally transferred phenytoin in the newborn studied with mass fragmentography. Clin. Pharmacol. Ther.15 39–45 (1974)

    Google Scholar 

  8. Palmér, L., Bertilsson, L., Collste, P., Rawlins, M.: Quantitative determination of carbamazepine in plasma by mass fragmentography. Clin. Pharmacol. Ther.14 827–832 (1973)

    Google Scholar 

  9. Rawlins, M.D., Collste, P., Bertilsson, L., Palmér, L.: Distribution and elimination kinetics of carbamazepine in man. Europ. J. clin. Pharmacol.8 91–96 (1975)

    Google Scholar 

  10. Eichelbaum, M., Ekbom, K., Bertilsson, L., Ringberger, V.A., Rane, A.: Plasma kinetics of carbamazepine and its expoxide metabolite in man during single and multiple dosing. Europ. J. clin. Pharmacol. (In press 1975)

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Authors and Affiliations

  1. Dept. of Clinical Pharmacology, Karolinska Institutet (Huddinge University Hospital), Huddinge, Sweden

    A. Rane, L. Bertilsson & Lena Palmér

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  1. A. Rane
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  2. L. Bertilsson
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  3. Lena Palmér
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Rane, A., Bertilsson, L. & Palmér, L. Disposition of placentally transferred carbamazepine (Tegretol®) in the newborn. Eur J Clin Pharmacol 8, 283–284 (1975). https://doi.org/10.1007/BF00567129

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  • DOI: https://doi.org/10.1007/BF00567129

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