Summary
The plasma concentrations of carbamazepine and its 10,11-epoxide were measured in 37 children and 13 adults with epilepsy during maintenance therapy. The children formed relatively more of the epoxy metabolite than adults. The daily dose, expressed as mg/kg or mg/m2, showed a statistically significant correlation with blood level in children, but not in adults. The cerebrospinal fluid concentrations of carbamazepine and carbamazepine-10,11-epoxide in nine children were 33 and 41 per cent, respectively, of the concomitant plasma level.
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Faigle, J. W., Feldmann, K. F.: Pharmacokinetic data of carbamazepine and its major metabolites in man. In: Clinical pharmacology of antiepileptic drugs (ed. H. Schneider, D. Janz, C. Gardner-Thorpe, H. Meinardi, A. L. Sherwin), pp. 159–165. Berlin, Heidelberg, New York: Springer 1975
Morselli, P. L., Biandrate, P., Frigerio. A., Gerna, M., Tognoni, G.: Gas chromatographic determination of carbamazepine and carbamazepine 10,11-epoxide in human body fluids. In: Methods of analysis of antiepileptic drugs (ed. J. W. A. Meijer, H. Meinardi, C. Gardner-Thorpe, E. van der Kleijn), pp. 169–175. Amsterdam: Excerpta Medica 1973
Cereghino, J. J., Van Meter, J.C., Brock, J. T., Penry, J. K., Smith, L. D., White, B. G.: Preliminary observations of serum carbamazepine concentration in epileptic patients. Neurology (Minneap.)23, 357–366 (1973)
Cereghino, J. J., Brock, J. T., Van Meter, J. C., Penry, J. K., Smith, L. D., White, B. C.: Carbamazepine for epileptic patients. A controlled prospective evaluation. Neurology (Minneap.)24, 401–410 (1974)
Pynnönen, S., Frey, H., Sillanpää, M.: Concentrations of carbamazepine and its main metabolite 10,11-epoxy derivative in serum with a new GLC method. 21. Nordiska Neurologkongressen, Stockholm, June 11–14, 1975
Clane, D. B.: Therapeutics in neurology, p. 15. Oxford, London, Edinburgh, Melbourne: Blackwell Scientific Publications 1975
Eichelbaum, M., Ekbom, K., Bertilsson, L., Ringberger, V. A., Rane, A.: Plasma kinetics of carbamazepine and its epoxide metabolite in man after single and multiple doses. Eur. J. clin. Pharmacol.8, 337–341 (1975)
Troupin, A. S., Green, J. K., Halpern, L. M.: Carbamazepine (Tegretol) as an anticonvulsant. A controlled double-blind comparison with diphenylhydantoin (Dilantin). Acta neurol. scand. (Suppl.)50, 13–26 (1975)
Pynnönen, S., Sillanpää, M., Frey, H., Iisalo, E.: Serum concentration of carbamazepine: Comparison of Herrmann's spectrophotometric method and a new GLC method for the determination of carbamazepine. Epilepsia (Amst.)17, 67–72 (1976)
Frigerio, A., Baker, K. M., Blevedere, G.: Gas chromatographic degradation of several drugs and their metabolites. Anal. Chem.45, 1846–1851 (1973)
Garrettson, L. K., Dayton, P. G.: Disappearance of phenobarbital and diphenylhydantoin from serum of children. Clin. Pharmacol. Ther.11, 674–679 (1970)
Heinze, E., Kampffmeyer, H. G.: Biological half-life of phenobarbital in human babies. Klin. Wschr.49, 1146–1147 (1971)
Rane, A.: Urinary excretion of diphenylhydantoin metabolites in newborn infants. J. Pediat.85, 543–545 (1974)
Sherwin, A. L., Loynd, J. S., Bock, G. W., Sokolowski, C. D.: Effects of age, sex, obesity and pregnancy on plasma diphenylhydantoin levels. Epilepsia (Amst.)15, 507–521 (1974)
Alvares, A. P., Kapelner, S., Sassa, S., Kapps, A.: Drug metabolism in normal children, lead-poisoned children, and normal adults. Clin. Pharmacol. Ther.17, 179–183 (1975)
Christiansen, J., Dam, M.: Influence of phenobarbital and diphenylhydantoin on plasma carbamazepine levels in patients with epilepsy. Acta neurol. scand.49, (543–546 (1973)
Dam, M., Jensen, A., Christiansen, J.: Plasma level and effect of carbamazepine in grand mal and psychomotor epilepsy. Acta neurol. scand.60, (Suppl.) 33–38 (1975)
Schenkman, J. B., Robie, K. M., Jansoon, J.: In: Abstracts of Active intermediates: formation, toxicity and inactivation. IUPHAR Satellite Symposium, Turku, July 26–27, 1975
Rane, A., Höjer, B., Wilson, J. T.: Kinetics of carbamazepine and its 10,11-epoxide metabolite in children. Clin. Pharmacol. Ther.19, 276–283 (1976)
Morselli, P. L.: Carbamazepine: Absorption, distribution and excretion. In: Complex partial seizures, Advances in Neurology (ed. J. K. Penry, D. D. Daly), pp. 279–293. New York: Raven Press 1975
Eichelbaum, M., Bertilsson, L., Lund, L., Palmer, L., Sjöquist, F.: Plasma levels of carbamazepine and carbamazepine-10,11-epoxide during treatment of epilepsy. Eur. J. clin. Pharmacol.9, 417–421 (1976)
Moeller, J.: Serumkoncentrations bestämningar av karbamazepin inom barnneurologin. In: Plasmakoncentrations bestämningar av antiepileptika; metodologiska och kliniska aspekter (ed. L. Lund), pp. 72–79, Lidingö: Tre punkter AB 1971
Scheiffarth, F., Weist, F., Zicha, L.: Zum Nachweis von 5-Carbamyl-5H-dibenzo(b,f)azepin im Liquor cerebrospinalis mittels Dünnschichtchromatographie. Z. klin. Chem.4, 68–70 (1966)
Weist, F., Zicha, L.: Dünnschichtchromatographische Untersuchungen über 5-Carbamyl-5H-dibenzo(b,f)azepin in Harn und Liquor bei neuen Indikationsgebieten. Arzneimittel-Forsch.17, 874–875 (1967)
Morselli, P., Frigerio, A.: Metabolism and pharmacokinetics of carbamazepine. Drug Metab. Rev.1, 97–113 (1975)
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Pynnönen, S., Sillanpää, M., Frey, H. et al. Carbamazepine and its 10,11-epoxide in children and adults with epilepsy. Eur J Clin Pharmacol 11, 129–133 (1977). https://doi.org/10.1007/BF00562904
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DOI: https://doi.org/10.1007/BF00562904