Summary
In 14 patients with atopic dermatitis and in controls the transepidermal water loss was measured in dorsal skin of hands by an electrolytic water analyser. Uninvolved as well as some cases with dry but not inflamed skin were used. A significant increase of transepidermal water loss was found in atopic dermatitis. Transepidermal water loss was simultaneously measured with skin surface lipids remaining on the hands. It was assumed that qualitative changes in the skin lipids, by influencing water-binding substances, may play a role in increased transepidermal water loss.
Zusammenfassung
Bei 14 Patienten mit atopischem Ekzem und bei einer Kontrollgruppe wurde mit einem elektrolytischen Wasseranalysator die transepidermalen Feuchtigkeitsabgabe in unveränderter Haut, bei einigen Fällen im Bereich trockener, aber nichtentzündeter Haut des Handrückens gemessen.
Eine signifikante Vermehrung der transepidermalen Feuchtigkeitsabgabe wurde bei atopischem Ekzem gefunden.
Mit der Feuchtigkeitsabgabe wurden gleichzeitig die Lipide der Hautoberfläche an den Handrücken gemessen; es wird angenommen, daß die nachgewiesenen qualitativen Veränderungen der Hautlipide durch ihren Einfluß auf wasserbindende Substanzen eine Rolle bei der vermehrten transepidermalen Feuchtigkeitsabgabe spielen.
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Rajka, G. Transepidermal water loss on the hands in Atopic Dermatitis. Arch. Derm. Res. 251, 111–115 (1974). https://doi.org/10.1007/BF00560391
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DOI: https://doi.org/10.1007/BF00560391