Summary
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1.
Substance P (synthetic or extracted from intestine or central nervous system) is devoid of an algesic effect on paravascular pain receptors.
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2.
The algesic effect of a SP-containing acetone HCl-extract from spinal cord is explained by its high content of potassium ions.
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3.
SP-containing preparations which include an ammonium sulphate precipitation in the extraction procedure are algesic due to content of this salt.
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4.
SP-containing extract from intestine were found to be contaminated with a bradykinin-like peptide of high algesic potency.
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5.
These findings are discussed with regard to the restricted value of earlier results about central actions of SP-containing tissue extracts and with regard to the role of SP as a possible neurotransmitter.
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Lembeck, F., Gamse, R. Lack of algesic effect of substance P on paravascular pain receptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 299, 295–303 (1977). https://doi.org/10.1007/BF00500324
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DOI: https://doi.org/10.1007/BF00500324