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Electrical excitability of motoneurones in early local tetanus

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Summary

  1. 1.

    After injection of tetanus toxin into the gastrocnemius muscle of the cat non-synaptic excitability of motoneurones was studied in early local tetanus. Antidromic stimulation of motoneurones was performed on the toxin-treated side and on the control side of the same cat.

  2. 2.

    The mean resting membrane potential of the motoneurones on the toxin-treated side did not differ from that on the control side.

  3. 3.

    Similarly, no differences were found as to the amplitude of the action potential and its rate of rise as well as to the size and time course of the after-hyperpolarization.

  4. 4.

    The mean input resistance of the motoneurones of the toxintreated side did not differ from that of the motoneurones of the control side.

  5. 5.

    Tetanus toxin did not change the mean refractory period and latency of antidromic responses.

  6. 6.

    It is concluded that the action of tetanus toxin in the spinal cord cannot be explained by an action of the toxin on the electrically excitable membrane elements of the motoneurones.

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References

  • Benecke, R., Takano, K., Schmidt, J., Henatsch, H. D.: Tetanus toxin induced actions on spinal Renshaw cells and I a inhibitory interneurones during development of local tetanus in the cat. Exp. Brain Res. 27, 271–286 (1977)

    Google Scholar 

  • Brock, L. G., Coombs, J. S., Eccles, J. C.: The recording of potentials from motoneurones with an intracellular electrode. J. Physiol. (Lond.) 117, 431–460 (1952)

    Google Scholar 

  • Brooks, V. B., Curtis, D. R., Eccles, J. C.: The action of tetanus toxin on the inhibition of motoneurones. J. Physiol. (Lond.) 135, 655–672 (1957)

    Google Scholar 

  • Burke, R. E., Strick, P. L., Kanda, K., Kim, C. C., Walmsley, B.: Anatomy of medial gastrocnemius and soleus motor nuclei in cat spinal cord. J. Neurophysiol. 40, 667–680 (1977)

    Google Scholar 

  • Clauß, G., Ebner, H.: Grundlagen der Statistik. Zürich: H. Deutsch 1975

    Google Scholar 

  • Coombs, J. S., Curtis, D. R., Eccles, J. C.: The electrical constants of the motoneurone membrane. J. Physiol. (Lond.) 145, 505–528 (1959)

    Google Scholar 

  • Curtis, D. R., de Groat, W. C.: Tetanus toxin and spinal inhibition. Brain Res. 10, 208–212 (1968)

    Google Scholar 

  • Curtis, D. R., Game, C. J. A., Lodge, D., McCulloch, R. M.: A pharmacology study of Renshaw cell inhibition. J. Physiol. (Lond.) 258, 227–242 (1976)

    Google Scholar 

  • Dimpfel, W., Habermann, E.: Histoautoradiographic localization of 125I-tetanus toxin in rat spinal cord. Naunyn-Schmiedebergs Arch. exp. Path. Pharmakol. 280, 177–182 (1973)

    Google Scholar 

  • Eccles, J. C.: The central action of antidromic impulses in motor nerve fibers. Pflügers Arch. 260, 385–415 (1955)

    Google Scholar 

  • Eccles, J. C.: The physiology of nerve cells. Baltimore: The Johns Hopkins Press 1957

    Google Scholar 

  • Eccles, J. C., Fatt, P., Koketsu, K.: Cholinergic and inhibitory synapses in a pathway from motor-axon collaterales to motoneurones. J. Physiol. (Lond.) 126, 524–562 (1954)

    Google Scholar 

  • Eccles, J. C., Eccles, R. M., Lundberg, A.: The convergence of monosynaptic excitatory afferents on to many different species of alpha motoneurones. J. Physiol. (Lond.) 137, 22–50 (1957)

    Google Scholar 

  • Erdmann, G., Wiegand, H., Wellhöner, H. H.: Intraaxonal and extraaxonal transport of 125I-tetanus toxin in early local tetanus. Naunyn-Schmiedeberg's Arch. Pharmacol. 290, 357–373 (1975)

    Google Scholar 

  • Green, J., Erdmann, G., Wellhöner, H. H.: Is there retrograde axonal transport of tetanus toxin in both α and γ fibres? Nature 265, 370 (1977)

    Google Scholar 

  • Green, J., Erdmann, G., Wellhöner, H. H.: Distribution of 125I-tetanus toxin in goldfish. Abstracts, 5th international conference on tetanus, Ronneby (in press, 1978)

  • Gushchin, I. S., Kozhechkin, S. N., Sverdlov, Yu. S.: Hyperpolarizing action of glycine on motoneurons blocked by tetanus toxin. Byullet. Eksp. Biol. Med. 70, 29–32 (1970)

    Google Scholar 

  • Hanauske, A., Erdmann, G., Wellhöner, H. H.: F(ab′)2-Tetanusantitoxin and purified F(ab′)2-antitoxin: Distribution after intrathecal application. Proceedings, 5th international conference on tetanus, Ronneby (in press, 1978)

  • Ito, M., Oshima, T.: Electrical behaviour of the motoneuronal membrane during intracellularly applied current steps. J. Physiol. (Lond.) 180, 607–635 (1965)

    Google Scholar 

  • Kernell, D.: Input resistance, electrical excitability and size of ventral horn cells in cat spinal cord. Science 152, 1637–1639 (1966)

    Google Scholar 

  • Kryzhanovsky, G. N., Aliev, M. N.: Creation of hyperactive determinant dispatch stations in the caudate nucleus in experimental neuropathological syndromes caused by tetanus toxin. Byullet. Exp. Biol. Med. 81, 477–479 (1976)

    Google Scholar 

  • Kryzhanovsky, G. N., Kurchavyi, G. G., Sheikhon, F. D.: Supraspinal effects on motoneurones in local tetanus. Byullet. Eksp. Biol. Med. 75, 36–39 (1973)

    Google Scholar 

  • Kryzhanovsky, G. N., Rekhtman, M. B., Konnikov, B. A., Sheikhon, F. D.: An experimental vestibulopathy produced by formation of a pathologically enhanced excitation generator in the vestibular nucleus (the determinant dispatch station phenomenon). Biullet. Exp. Biol. Med. 81, 141–145 (1976)

    Google Scholar 

  • Kuno, M., Miyata, Y., Munoz-Martinez, E. J.: Differential reaction of fast and slow alpha-motoneurones to axotomy. J. Physiol. (Lond.) 240, 725–739 (1974)

    Google Scholar 

  • Mellanby, J., George, G., Robinson, A., Thompson, Ph.: Epileptiform syndrome in rats produced by injecting tetanus toxin into the hippocampus. J. Neurol. Neurosurg. Psychiat. 40, 404–414 (1977)

    Google Scholar 

  • Mikhailov, V. V., Shvarts, J. L.: Microphysiological analysis of electrical activity of spinal neurons of various types in experimental tetanus. Byullet. Eksp. Biol. Med. 68, 20–23 (1969)

    Google Scholar 

  • Osborne, R. H., Bradford, H. F.: Tetanus toxin inhibits aminoacid release from nerve endings in vitro. Nature 244, 157–158 (1973)

    Google Scholar 

  • Price, D. L., Griffin, J., Young, Y., Peck, K., Stocks, A.: Tetanus toxin: direct evidence for retrograde, intraaxonal transport. Science 188, 945–947 (1975)

    Google Scholar 

  • Schwab, M., Thoenen, H.: Electron microscopic evidence for a transsynaptic migration of tetanus toxin in spinal cord motoneurones: an autoradiographic and morphometric study. Brain Res. 105, 213–227 (1976)

    Google Scholar 

  • Stoeckel, K., Schwab, M., Thoenen, H.: Comparison between the retrograde axonal transport of nerve growth factor and tetanus toxin in motor, sensory and adrenergic neurons. Brain Res. 99, 1–16 (1975)

    Google Scholar 

  • Sverdlov, Yu. S.: Potentials of spinal motoneurons in cats with experimental tetanus. Neirofiziologiya 1, 25–34 (1969)

    Google Scholar 

  • Wellhöner, H. H., Hensel, B., Seib, U. C.: Local tetanus in cats: Neuropharmacokinetics of 125I-tetanus toxin. Naunyn-Schmiedeberg's Arch. Pharmacol. 276, 375–386 (1973a)

    Google Scholar 

  • Wellhöner, H. H., Seib, U. C., Hensel, B.: Local tetanus in cats: The influence of neuromuscular activity on spinal distribution of 125I-labelled tetanus toxin. Naunyn-Schmiedeberg's Arch. Pharmacol. 276, 387–394 (1973b)

    Google Scholar 

  • Wernig, A., Stöver, H., Tonge, D.: The labelling of motor end-plates in skeletal muscle of mice with 125I-tetanus toxin. Naunyn-Schmiedeberg's Arch. Pharmacol. 298, 37–42 (1977)

    Google Scholar 

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Author notes

  1. H. Wiegand

    Present address: Abteilung Toxikologie, Medizinisches Institut für Lufthygiene und Silikoseforschung an der Universität Düsseldorf, Gurlittstrasse 53, D-4000, Düsseldorf

  2. H. Wellhöner

    Present address: Abteilung Toxikologie, Medizinische Hochschule Hannover, Karl-Wiechert-Allee 9, D-3000, Hannover 61, Germany

Authors and Affiliations

  1. Pharmakologisches Institut der Justus-Liebig-Universität Gießen, Frankfurter Strasse 107, D-6300, Gießen, Germany

    H. Wiegand & H. Wellhöner

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  1. H. Wiegand
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Wiegand, H., Wellhöner, H. Electrical excitability of motoneurones in early local tetanus. Naunyn-Schmiedeberg's Arch. Pharmacol. 308, 71–76 (1979). https://doi.org/10.1007/BF00499722

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  • DOI: https://doi.org/10.1007/BF00499722

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