Skip to main content
Log in

Bacterial endophthalmitis in neonates

  • Annotation
  • Published:
European Journal of Pediatrics Aims and scope Submit manuscript

Abstract

Invasive bacterial eye infections in the neonate range from perforating keratitis to panophthalmitis. These infections have gained clinical and therapeutic importance since mortality rates are high and prognosis concerning preservation of vision is poor. Effective antibiotics against the infective agents are now available. Risk factors for developing invasive bacterial eye infections are mainly prematurity and colonisation with Pseudomonas aeruginosa.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Abbreviations

GBS:

group B streptococci

SGA:

small for gestational age

References

  1. Anderson EL, Stager D, Levin DL (1982) Pseudomonas aeruginosa infections in seriously ill children. Clin Pediatr 21:123–124

    Google Scholar 

  2. Armstrong JH, Zacarias F, Rein MF (1976) Ophthalmia neonatorum: a chart review. Pediatrics 57:884–892

    Google Scholar 

  3. Baley JE, Annable WL, Kliegman RM (1981) Candida endophthalmitis in the premature infant. J Pediatr 98:458–461

    Google Scholar 

  4. Baum JM (1978) Current concepts in ophthalmology. Ocular infections. N Engl J Med 299:28–31

    Google Scholar 

  5. Belohradsky BH (1981) Immunität und Infektionen des Neugeborenen. Urban & Schwarzenberg, München Wien Baltimore

    Google Scholar 

  6. Berger BB (1981) Endophthalmitis complicating neonatal group B streptococcal septicemia. Am J Ophthalmol 92:681–684

    Google Scholar 

  7. Böke W, Thiel H-J (1973) Zur konservativen Therapie der Hypopyonkeratitis und des Hornhautabszesses. Klin Monatsbl Augenheilkd 163:125–131

    Google Scholar 

  8. Brook I, Martin JW, Finegold SM (1978) Effect of silver nitrate application on the conjunctival flora of the newborn: and the occurrence of clostridial conjunctivitis. J Pediatr Ophthalmol Strabismus 15:179–183

    Google Scholar 

  9. Brook I, Barrett CT, Brinkman CR, Martin JW, Fingegold SM (1979) Aerobic and anaerobic bacterial flora of the maternal cervix and newborn gastric fluid and conjunctiva: a prospective study. Pediatrics 63:451–455

    Google Scholar 

  10. Brown SI, Bloomfield SE, Wai-Fong IT (1974) The cornea destroying enzyme of pseudomonas aeruginosa. Invest Ophthalmol 11:174–177

    Google Scholar 

  11. Burnard ED (1959) Proptosis as the first sign of orbital sepsis in the newborn. Br J Ophthalmol 43:9–12

    Google Scholar 

  12. Burns RP, Rhodes DH (1961) Pseudomonas eye infections as a cause of death in premature infants. Arch Ophthalmol 65:517–525

    Google Scholar 

  13. Cole DF, Davies DP, Austin DJ (1980) Pseudomonas ophthalmia neonatorum: a cause of blindness. Br Med J 2:440–441

    Google Scholar 

  14. Corcelle M, Baylot F, Roques L (1962) Infections oculaires néonatales dans un service de prématurés. Bull Soc Ophthalmol Fr 62:585–587

    Google Scholar 

  15. Corman LI, Poirier RH, Littlefield CH, Sumaya CV (1979) Endophthalmitis due to salmonella enteritidis. J Pediatr 95:1001–1002

    Google Scholar 

  16. Doden W (1975) Augeninfektionen. In: Otten H, Plempel M, Siegenthaler W (eds) Antibiotika-Fibel Walter AM und Heilmeyer L, 4th edn. Thieme, Stuttgart, pp 908–925

    Google Scholar 

  17. Drewett SE, Tuke W, Payne DJH, Verdon PE (1972) Eradication of pseudomonas infection from a special-care nursery. Lancet I:946–948

    Google Scholar 

  18. Edwards JE, Foos RY, Montgomery JZ, Guze LB (1974) Ocular manifestations of candida septicemia: review of seventy-six cases of hematogenous candida endophthalmitis. Medicine 53:47–75

    Google Scholar 

  19. Eliachar E, Benand R, Tassy R, Beust M, Grebert M (1966) Fonte purulente de œil par bacille pyocyanique chez un nouveauné prématuré. Ann Pédiatr 13:178–180

    Google Scholar 

  20. Eliachar R, Tassy R, Tournier G (1968) Le rôle de pseudomonas aeruginosa dans les infections oculaires du prématuré et du nouveau-né. Ann Pédiatr 15:461–465

    Google Scholar 

  21. Fishman LS, Griffin JR, Sapico FL, Hecht R (1972) Hematogenous candida endophthalmitis — a complication of candidemia. N Engl J Med 286:675–681

    Google Scholar 

  22. Forster RK (1985) Endophthalmitis. In: Duane TD (ed) Clinical ophthalmology, vol 4, revised edn. Harper Row, New York, pp 1–20

    Google Scholar 

  23. Friendly DS (1983) Ophthalmia neonatorum. Pediatr Clin North Am 30:1033–1042

    Google Scholar 

  24. Greene GR, Carroll WL, Morozumi PA (1979) Endophthalmitis associated with group B streptococcal meningitis in an infant. Am J Dis Child 133:752–753

    Google Scholar 

  25. Grieble HG (1970) Fine-particle humidifiers. Source of pseudomonas aeruginosa infections in a respiratory disease unit. N Engl J Med 283:531–532

    Google Scholar 

  26. Handrick W, Weller K, Matzen C, Rieske K, Spencker F-B (1983) Fanophthalmie durch Pseudomonas bei einem Neugeborenen — ein Beitrag zur ophthalmologisch-pädiatrischen Zusammenarbeit. Kinderärztl Prax 51:269–274

    Google Scholar 

  27. Hill HR, Mitchell TG, Matsen JM, Quie PG (1974) Recovery from disseminated candidiasis in a premature neonate. Pediatrics 53:748–752

    Google Scholar 

  28. Howard JB, McCracken GH (1974) The spectrum of group B streptococcal infections in infancy. Am J Dis Child 128:815–818

    Google Scholar 

  29. Kanski JJ, Young JH, Vogel R (1982) Penetration of intravenously administered cefoxitin into the aqueous humor of inflamed human eyes. Am J Ophthalmol 94:516–518

    Google Scholar 

  30. Kreger AS, Griffin OK (1974) Physicochemical fractionation of extracellular cornea-damaging proteases of pseudomonas aeruginosa. Infect Immun 9:829–834

    Google Scholar 

  31. Locatcher-Khorazo D, Seegal BC (1972) The bacterial flora of the healthy eye. In: Locatcher-Khorazo D, Seegal BC (eds) Microbiology of the eye. Mosby, St Louis, pp 13–23

    Google Scholar 

  32. Mason W, Igdaloff S, Friedman R, Wright HT (1979) Meningococcal sepsis with endopthalmitis. Am J Dis Child 133:1151–1152

    Google Scholar 

  33. Michelson PE, Rupp R, Efthimiadis B (1975) Endogenous candida endophthalmitis leading to bilateral corneal perforation. Am J Ophthalmol 80:800–803

    Google Scholar 

  34. Molgaard I-L, Nielsen PB, Kaern J (1984) A study of the incidence of neonatal conjunctivitis and of its bacterial causes including chlamydia trachomatis. Acta Ophthalmol 62:461–471

    Google Scholar 

  35. Nussbaum E, Jeyaranjan T, Feldman F (1978) Primary meningococcal conjunctivitis followed by meningitis. J Pediatr 92:784–785

    Google Scholar 

  36. Palmer EA (1980) Endogenous candida endophthalmitis in infants. Am J Ophthalmol 89:388–395

    Google Scholar 

  37. Peyman GA, May DR, Ericson ES, Apple D (1974) Intraocular injection of gentamicin. Arch Ophthalmol 92:42–47

    Google Scholar 

  38. Peyman GA, Vastin DW, Cronch ER, Herbst RU (1974) Clinical use of intravitreal antibiotics to treat bacterial endophthalmitis. Trans Am Acad Ophthalmol Otolaryngol 78:862–875

    Google Scholar 

  39. Pierce JM, Ward ME, Seal DV (1982) Ophthalmia neonatorum in the 1980's: incidence, aetiology and treatment. Br J Ophthalmol 66:728–731

    Google Scholar 

  40. Prentice MJ, Hutchinson GR, Taylor-Robinson D (1977) A microbiological study of neonatal conjunctivae and conjunctivitis. Br J Opthalmol 61:601–607

    Google Scholar 

  41. Reeder JC, Westwell AJ, Hutchinson DN (1985) Indifferent streptococci in normal and purulent eyes of neonates. J Clin Pathol 38:942–945

    Google Scholar 

  42. Sandström KI, Bell AT, Chandler JW, Cho-Chou K, San-Pin W, Grayston W, Hjordis MF, Stamm WE, Cooney MK, Smith AL, Holmes KK (1984) Microbial causes of neonatal conjunctivitis. J Pediatr 105:706–711

    Google Scholar 

  43. Speer HE, Hittner HM, Rudolph AJ (1980) Candida endophthalmitis: a manifestation of candidiasis in the neonate. South Med J 73:1407–1409

    Google Scholar 

  44. Taylor JRW, Cibis GW, Hamptil LW (1980) Endophthalmitis complicating haemophilus influenzae type b meningitis. Arch Ophthalmol 98:324–326

    Google Scholar 

  45. Tinne JE (1967) Pseudomonas infection in the hospital. Br Med J 4:313–315

    Google Scholar 

  46. Weintraub MI, Otto RN (1972) Pneumococcal meningitis and endophthalmitis in a newborn. JAMA 219:1763–1764

    Google Scholar 

  47. Wilson LA (1985) Bacterial corneal ulcers. In: Duane TD (ed) Clinical ophthalmology, vol 4, revised edn. Harper & Row, New York, pp 1–19

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lohrer, R., Belohradsky, B.H. Bacterial endophthalmitis in neonates. Eur J Pediatr 146, 354–359 (1987). https://doi.org/10.1007/BF00444936

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00444936

Key words

Navigation