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Control of the initiation of DNA replication in Escherichia coli

I. Negative control of initiation

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Summary

A transient stimulation of the initiation of DNA replication during inhibition of protein synthesis has been demonstrated in dnaA5 and dnaA46 mutants. This suggests the existence of a negatively acting control protein (not the dnaA product) which decays rapidly or is removed during a block in protein synthesis. The stimulation of initiation is dependent on a previous accumulation of initiation specific proteins, which suggests that in addition to the negative control other control mechanisms are effective.

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Author notes

  1. Gabriele Zahn

    Present address: Deutsches Krebsforschungszentrum, Institut für Immunologie und Genetik, D-6900, Heidelberg, Federal Republic of Germany

Authors and Affiliations

  1. Max-Planck-Institut für molekulare Genetik, Ihnestrasse 63/73, D-1000, Berlin 33

    Ruth Tippe-Schindler, Gabriele Zahn & Walter Messer

Authors
  1. Ruth Tippe-Schindler
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  2. Gabriele Zahn
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  3. Walter Messer
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Communicated by E. Bautz

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Tippe-Schindler, R., Zahn, G. & Messer, W. Control of the initiation of DNA replication in Escherichia coli . Molec. Gen. Genet. 168, 185–195 (1979). https://doi.org/10.1007/BF00431444

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  • DOI: https://doi.org/10.1007/BF00431444

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