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Chemical structure and biological activities of lipid A's from various bacterial families

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Abstract

The endotoxic principle of lipopolysaccharides (LPS) is localized in their lipid A component. Biological effects of LPS on, for instance, body temperature, blood pressure, and blood picture, are also induced by free lipid A. In contrast to the great variability of the 0-specific chains, the chemical structure of lipid A is much more constant. It is common for Salmonella and similar for other genera of the Enterobacteriaceae. Recently, a number of lipid A's have been recognized that exhibited distinct structural features compared with Enterobacteriaceae. These lipid A's were found to be also distinct with regard to some of their biological properties.

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References

  1. Westphal, O.: Praxis 40, 789 (1951)

    Google Scholar 

  2. Westphal, O., Bister, F.: FIAT Rev. Ger. Sci. Biochem. II 1948, 96

  3. Westphal, O., Lüderitz, O., Bister, F.: Z. Naturforsch. 7b, 148 (1952)

    Google Scholar 

  4. Westphal, O., Jann, K.: Methods Carbohydr. Chem. 5, 83 (1965)

    Google Scholar 

  5. Westphal, O., et al.: Z. Naturforsch. 7b, 536 (1952)

    Google Scholar 

  6. Keiderling, W., Wöhler, F., Westphal, O.: Arch. Exp. Pathol. Pharmakol. 217, 293 (1953)

    Google Scholar 

  7. Westphal, O., Westphal, U., Sommer, Th., in: Microbiology, p. 221 (Schlessinger, D., ed.). Washington, D.C.: Am. Soc. Microbiol. 1977

    Google Scholar 

  8. Kauffmann, F., et al.: Zentralbl. Bakteriol. Parasitenk. Abt. I. Orig. 178, 442 (1960)

    Google Scholar 

  9. Lüderitz, L., Staub, A.M., Westphal, O.: Bacteriol. Rev. 30, 192 (1966)

    Google Scholar 

  10. Westphal, O., Lüderitz, O.: Angew. Chem. 66, 407 (1954)

    Google Scholar 

  11. Galanos, C., et al.: Int. Rev. Biochem. 14, 239 (1977)

    Google Scholar 

  12. Lüderitz, O., in: Microbiology, p. 239 (Schlessinger, D., ed.). Washington, D.C.: Am. Soc. Microbiol. 1977

    Google Scholar 

  13. Rietschel, E.Th., et al., in: ibid., p. 262, 344

    Google Scholar 

  14. Galanos, C., et al., in: ibid., p. 269

    Google Scholar 

  15. Gmeiner, J., Lüderitz, O., Westphal, O.: Eur. J. Biochem. 7, 370 (1969)

    Google Scholar 

  16. Gmeiner, J., Simon, M., Lüderitz, O.: ibid. 21, 355 (1971)

    Google Scholar 

  17. Rietschel, E.Th., et al.: ibid. 28, 166 (1972)

    Google Scholar 

  18. Bryn, K., Rietschel, E.Th.: ibid. (in press)

  19. Mühlradt, P.F., Wray, V., Lehmann, V.: ibid. 81, 193 (1977)

    Google Scholar 

  20. Osborn, M.J., et al.: Ann. NY Acad. Sci. 235, 52 (1974)

    Google Scholar 

  21. Rick, P.D., Osborn, M.J.: J. Biol. Chem. 252, 4895 (1977)

    Google Scholar 

  22. Rick, P.D., et al.: ibid. 252, 4904 (1977)

    Google Scholar 

  23. Lehmann, V.: Eur. J. Biochem. 75, 257 (1977)

    Google Scholar 

  24. Lehmann, V., Rupprecht, E., Osborn, M.J.: ibid. 76, 41 (1977)

    Google Scholar 

  25. Lehmann, V., Rupprecht, E.: ibid. 81, 443 (1977)

    Google Scholar 

  26. Munson, R.S., Osborn, M.J.: Fed. Proc. 34, 669 (1975)

    Google Scholar 

  27. Hase, S., Rietschel, E.Th.: Eur. J. Biochem. 75, 23 (1977)

    Google Scholar 

  28. Tharanathan, R.N., Weckesser, J., Mayer, H.: ibid. 84, 385 (1978)

    Google Scholar 

  29. Hurlbert, R.E., et al.: ibid. 68, 365 (1976)

    Google Scholar 

  30. Adams, G.A., et al.: Can. J. Microbiol. 16, 1 (1970)

    Google Scholar 

  31. Weckesser, J., et al.: Arch. Microbiol. 101, 233 (1974)

    Google Scholar 

  32. Keilich, G., Roppel, J., Mayer, H.: Carbohydr. Res. 51, 129 (1976)

    Google Scholar 

  33. Drews, G., Weckesser, J., Mayer, H., in: The Photosynthetic Bacteria (Clayton, R.K., Sistrom, W.R., eds.). New York: Plenum (in press)

  34. Galanos, C., Lüderitz, O., Westphal, O.: Eur. J. Biochem. 24, 116 (1971)

    Google Scholar 

  35. Rietschel., E.Th., Galanos, C.: Infect. Immun. 15, 34 (1977)

    Google Scholar 

  36. Galanos, C., et al.: ibid. 16, 407 (1977)

    Google Scholar 

  37. Galanos, C., et al.: Eur. J. Biochem. 19, 143 (1971)

    Google Scholar 

  38. Galanos, C., Lüderitz, O.: ibid. 65, 403 (1976)

    Google Scholar 

  39. Freudenberg, M.A., Galanos, C.: Infect. Immun. (in press)

  40. Lugowski, C., Romanowska, E.: Eur. J. Biochem. 48, 81 (1974)

    Google Scholar 

  41. Jay, F., Galanos, C.: in preparation; Jay, F.: Thesis Guildford, U.K. 1978

  42. Andersson, J., et al.: J. Exp. Med. 137, 943 (1973); Lehmann, V., Ruschmann, E., Minner, I.: in preparation

    Google Scholar 

  43. Hase, S., Rietschel, E.Th.: Eur. J. Biochem. 63, 101 (1976); Adams, G.A., Singh, P.P.: Can. J. Biochem. 48, 55 (1970); 49, 243 (1971); Biochim. Biophys. Acta 202, 553 (1970); Lugowski, C., Romanowska, E.: Eur. J. Biochem. 48, 319 (1974); Sidorczyk, Z.: unpublished

    Google Scholar 

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Authors and Affiliations

  1. Max-Planck-Institut für Immunbiologie, D-7800, Freiburg/Br.

    Otto Lüderitz, Chris Galanos, Volker Lehmann, Hubert Mayer, Ernst Th. Rietschel & Jürgen Weckesser

  2. Lehrstuhl für Mikrobiologie der Universität, D-7800, Freiburg/Br.

    Otto Lüderitz, Chris Galanos, Volker Lehmann, Hubert Mayer, Ernst Th. Rietschel & Jürgen Weckesser

Authors
  1. Otto Lüderitz
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  2. Chris Galanos
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  3. Volker Lehmann
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  4. Hubert Mayer
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  5. Ernst Th. Rietschel
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  6. Jürgen Weckesser
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Dedicated to Professor Dr. Otto Westphal on the occasion of his 65th birthday (February 1, 1978)

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Lüderitz, O., Galanos, C., Lehmann, V. et al. Chemical structure and biological activities of lipid A's from various bacterial families. Naturwissenschaften 65, 578–585 (1978). https://doi.org/10.1007/BF00364907

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  • DOI: https://doi.org/10.1007/BF00364907

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