Skip to main content
SpringerLink
Log in

Klinik und Pathophysiologie der initialen neurologischen Symptome bei fokalen Migränen (Migraine ophthalmique, Migraine accompagnée)

Clinical and pathophysiological considerations on initial neurological symptoms of focal migraine

  • Published:
Archiv für Psychiatrie und Nervenkrankheiten Aims and scope Submit manuscript

Summary

In 87 migraine patients (46 with ophthalmic migraine, 41 with migraine accompagnée) the development and localization of the initial focal symptoms were registered. Both groups showed similar developmental characteristics of the cortical type. In the initial phase, the migraine accompagnée also most often starts with disturbances of vision. This suggests, that the pathomechanism in both types is identical and differs only in intensity. The predominant role of the arteria cerebri posterior in migraine is again confirmed. Pathophysiology (spreading depression, hypoxia) and the neuronal organization of the visual cortex and their possible relation to visual symptoms are discussed.

Zusammenfassung

Bei 87 Patienten mit fokalen Migränen (46 opthalmische Migränen, 41 Migraine accompagnée) wurde versucht, Entwicklung und Lokalisation der einleitenden neurologischen Symptome zu erfassen. Beide Migräneformen ergaben eine ähnliche Entwicklungs- und Ausbreitungscharakteristik vom corticalen Typ. Da auch bei der Migraine accompagnée Sehstörungen in der Einleitungsphase im Vordergrund stehen, wird für beide Migräneformen der prinzipiell gleiche Pathomechanismus in nur unterschiedlich schwerer Ausprägung angenommen. Die Untersuchung bestätigt erneut die bevorzugte Rolle der A. cerebri posterior bei der Entstehung fokaler Migränen. Zur Erklärung der Symptomatik werden pathophysiologische Mechanismen (spreading depression, Hypoxie) und die neuronale Organisation des visuellen Cortex diskutiert.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literatur

  • Airy, H.: On a distinct form of transient hemianopsia. Phil. Trans. B 160, 247–264 (1870)

    Google Scholar 

  • Aquino-Cias, J., Bures, J.: Seizure irradiation during functional elimination of the thalamus by spreading depression in the rat. Epilepsia 8, 47–57 (1967)

    Google Scholar 

  • Barolin, G. S.: Familiäre paroxysmale Halbseitenausfälle mit und ohne Kopfschmerzattacken. Schweiz. Arch. Neurol. 99, 15–28 (1967)

    Google Scholar 

  • Barolin, G. S., Sperling, D.: Migränefamilien. Fortschr. Neurol. Psychiat. 37, 521–544 (1969)

    Google Scholar 

  • Barolin, G. S.: Migräne. Wien: Facultas 1969

    Google Scholar 

  • Baumgartner, G., Creutzfeldt, O., Jung, R.: Microphysiology of cortical neurones in acute anoxia and in retinal ischemia. Cerebral anoxia and EEG. H. Gastaut and J. S. Meyer, Eds. Springfield, Ill.: Ch. C. Thomas 1961

    Google Scholar 

  • Baumgartner, G.: Zur Klinik und Pathophysiologie der Migräne. Med. Welt 1962, 1915–1918

  • Beck, U., Manz, F.: Kindliche und juvenile fokale Migräne. Arch. Psychiat. Nervenheilk. 215, 407–416 (1972)

    Google Scholar 

  • Bickerstaff, E. R.: Basilar artery migraine. Lancet 1961 I, 15–17

    Google Scholar 

  • Bickerstaff, E. R.: Impairment of consciousness in migraine. Lancet 1961 II, 1057–1058

    Google Scholar 

  • Bures, J., Hartmann, G., Lukyanova, L. D.: Blockade of thalamocortical and pyramidal pathways by striatal spreading depression in rats. Exp. Neurol. 18, 404–415 (1967)

    Google Scholar 

  • Charcot, J. M.: Leçons du mardi. Übersetzt von S. Freud, Leipzig und Wien. 1, 60–61, 17–27 (1892)

    Google Scholar 

  • Charcot, J. M.: Nouvelle iconographie de la Salpêtrière, Vol. 8/I, 1895

  • Connor, R. C. R.: Complicated migraine. Lancet 1962 II, 1072

  • Daniel, P. M., Whitteridge, D.: The representation of the visual field on the cerebral cortex in monkeys. J. Physiol. (Lond.) 159, 203–221 (1961)

    Google Scholar 

  • Féré, Ch.: Contribution à l'étude de la migraine ophthalmique. Rev. Méd. (Paris) 1, 625–646 (1881)

    Google Scholar 

  • Friedman, A. P.: Migraine (Pathophysiology and Pathogenesis). Handbook of Clinical Neurology. Eds. P. J. Vinken and G. W. Bruyn. Vol. 5: Headaches and cranial neuralgias, pp. 37–44. Amsterdam: North-Holland Publ. Comp. 1968

    Google Scholar 

  • Galezowski, X.: Étude sur la migraine ophthalmique. Arch. gén. Med. 1, 669 (1878)

    Google Scholar 

  • Grafstein, B.: Mechanism of spreading cortical depression. J. Neurophysiol. 19, 154–171 (1956)

    Google Scholar 

  • Grafstein, B.: Locus of propagation of spreading cortical depression. J. Neurophysiol. 19, 309–316 (1956)

    Google Scholar 

  • Heyck, H.: Pathogenesis of migraine. Research and clinical studies in headache. A. P. Friedman, Ed., Vol.2, pp. 2–28. Basel-New York: S. Karger 1969

    Google Scholar 

  • Hubel, D. H., Wiesel, T. N.: Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. J. Physiol. (Lond.) 160, 106–154 (1962)

    Google Scholar 

  • Hubel, D. H., Wiesel, T. N.: Cortical and callosal connections concerned with the vertical meridian of visual fields in the cat. J. Neurophysiol. 30, 1561–1573 (1967)

    Google Scholar 

  • Hubel, D. H., Wiesel, T. N.: Receptive fields and functional architecture of monkey striate cortex. J. Physiol. (Lond.) 195, 215–243 (1968)

    Google Scholar 

  • Karol, E. A., Pandya, D. N.: The distribution of the corpus callosum in the rhesus mokey. Brain 94, 471–486 (1971)

    Google Scholar 

  • Kawamura, K.: Corticocortical fibre connections of the cat cerebrum. III. The occipital region. Brain Res. 51, 41–60 (1973)

    Google Scholar 

  • Lashley, K. S.: Patterns of cerebral integration indicated by the scotomas of migraine. Arch. Neurol. Psychiat. 46, 331–339 (1941)

    Google Scholar 

  • Leao, A. A. P.: Spreading depression of activity in cerebral cortex. J. Neurophysiol. 7, 359–390 (1944)

    Google Scholar 

  • Miller-Fisher, C.: Migraine accompagnée versus arteriosclerotic ischemia. Trans. Amer. neurol. Ass. 93, 211–213 (1968)

    Google Scholar 

  • Miller-Fisher, C.: Cerebral ischemia, less familiar types. Clin. Neurosurg. 18, 267–336 (1971)

    Google Scholar 

  • Milner, P. M.: Note on a possible correspondance between the scotomas of migraine and spreading depression of Leao. Electroenceph. clin. Neurophysiol. 10, 705 (1958)

    Google Scholar 

  • Moebius, P. J.: Die Migräne. Wien: A. Hölcher 1894

    Google Scholar 

  • Pandya, D. N., Karol, E. A., Heilbronn, D.: The topographical distribution of interhemispheric projections in the corpus callosum. Brain Res. 32, 31–43 (1970)

    Google Scholar 

  • Morlock, N. L., Moriand, K., Ward, A. A., Jr.: A study of single cortical neurons during spreading depression. J. Neurophysiol. 27, 1192–1198 (1964)

    Google Scholar 

  • Pearce, J.: Migraine. Springfield, Ill.: Ch. C. Thomas 1969

    Google Scholar 

  • Pick, A.: Zur Symptomatologie der funktionellen Aphasien, nebst Bemerkungen zur Migraine ophthalmique. Berl. klin. Wschr. 31, 1060–1090 (1894)

    Google Scholar 

  • Poeck, K.: Die Differentialdiagnose „Migraine accompagnée“ und sensible Jackson-Anfälle. Dtsch. med. Wschr. 97, 637–641 (1972)

    Google Scholar 

  • Richards, W.: The fortification illusion of migraine. Scient. Amer. 224, 89–96 (1971)

    Google Scholar 

  • Sacks, O. W.: Migraine. London: Faber & Faber 1971

    Google Scholar 

  • Selby, G., Lance, J. W.: Observations on 500 cases of migraine and allied vascular headache. J. Neurol. Neurosurg. Psychiat. 23, 23–32 (1960)

    Google Scholar 

  • Simard, D., Paulsen, O. B.: Cerebral vasomotor paralysis during migraine attack. Arch. Neurol. (Chic.) 29, 207–209 (1973)

    Google Scholar 

  • Skinhøj, E., Paulson, O.: Changes in focal cerebral blood flow within the internal carotid system during migraine attack. Acta neurol. scand. 46, Suppl. 43, 254 (1970)

    Google Scholar 

  • Thomas, L.: La migraine. Paris: A. Delahaye & E. Lecrosnier 1887

    Google Scholar 

  • Wegner, W.: Die Funktion der menschlichen Netzhaut bei experimenteller Ischaemia retinae. Arch. Augenheilk. 98, 5–15 (1928)

    Google Scholar 

  • Zieburtz, R.: Die Migraine accompagnée. Praxis 57, 1326–1332 (1968)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Neurologische Universitätsklinik Zürich, Schweiz

    H. Bücking & G. Baumgartner

  2. Neurologische Klinik mit Abteilung für Neurophysiologie der Universität Freiburg i. Br., Deutschland

    H. Bücking & G. Baumgartner

Authors
  1. H. Bücking
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Baumgartner
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bücking, H., Baumgartner, G. Klinik und Pathophysiologie der initialen neurologischen Symptome bei fokalen Migränen (Migraine ophthalmique, Migraine accompagnée). Arch. Psychiat. Nervenkr. 219, 37–52 (1974). https://doi.org/10.1007/BF00342994

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00342994

Key words

Schlüsselwörter

Search

Navigation