Abstract
We conducted a retrospective analysis of the cases of 122 children operated on for various brain tumors, to determine the incidence and natural history of post-operative diabetes insipidus (DI), and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Abnormalities of water homeostasis were observed in 15 patients (12%). DI, with or without SIADH, was observed in 10 patients (8%), while SIADH alone was seen in five (4%). DI was permanent in five subjects (50%), whereas SIADH resolved completely in all affected individuals. Parenteral desmopressin (dDAVP) was an effective mode of therapy in the postoperative period. The effect did not correlate with a dosage strictly based on body weight.
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Aronson AS, Andersson KE, Bergstrand CG, Mulder JL (1973) Treatment of diabetes insipidus in children with DDAVP, a synthetic analogue of vasopressin. Acta Paediatr Scand 62:133–140
Balestrieri FJ, Chernow B, Rainey TG (1982) Postcraniotomy diabetes insipidus: who's at risk? Crit Care Med 10:108–110
Becker DJ, Foley TP (1978) 1-Deamino-8-d-arginine vasopressin in the treatment of central diabetes insipidus in childhood. J Pediatr 92:1011–1018
Brisman R, Chutorian AM (1970) Inappropriate antidiruetic hormone secretion. Arch Neurol 23:63–93
Chanson P, Jedynak CP, Czernichow P (1988) Management of early post-operative diabetes insipidus with parenteral desmopressin. Acta Endocrinol 117:513–516
Cusick JF, Hagen TC, Findling JW (1984) Inappropriate secretion of antidiuretic hormone after transsphenoidal surgery for pituitary tumors. N Engl J Med 311:36–38
Czernichow P, Pomarede R, Brauner R, Rappaport R (1985) Neurogenic diabetes insipidus in children. Front Horm Res 13:190–209
Giacoia GP, Watson S, Karathanos A (1984) Treatment of neonatal diabetes insipidus with desmopressin. South Med J 77:75–77
Greger NG, Kirkland RT, Clayton GW, Kirkland JL (1986) Central diabetes insipidus. Am J Dis Child 140:551–554
Kauli R, Galatzer A, Laron Z (1985) Treatment of diabetes insipidus in children and adolescents. Front Horm Res 13:304–313
McDonald JA, Martha PM, Kerrigan J, Clarke WL, Rogol AD, Blizzard RM (1989) Treatment of the young child with postoperative central diabetes insipidus. Am J Dis Child 143:201–204
Randall RV, Clark EC, Dodge HW, Love JG (1960) Polyuria after operation for tumors in the region of the hypophysis and hypothalamus. J Clin Endocrinol Metab 20:1614–1621
Richardson DW, Robinson AG (1985) Desmopressin. Ann Intern Med 103:228–239
Sklar CA (1985) Diabetes insipidus. In: Zimmerman SS, Gildea JH (eds) Critical care pediatrics. Saunders, Philadelphia, pp 249–256
Verbalis JG, Robinson AG, Moses AM (1985) Postoperative and postraumatic diabetes insipidus. Front Horm Res 13:247–265
Weiser H, Robinson B (1984) Inappropriate secretion of antidiuretic hormone as a postoperative complication in a child with melulloblastoma. Surg Neurol 21:42–44
Yu VYH, Werther GA (1980) Treatment of neonatal diabetes insipidus with desmopressin (DDAVP). Aust Pediatr J 16:284–286
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Blumberg, D.L., Sklar, C.A., Wisoff, J. et al. Abnormalities of water metabolism in children and adolescents following craniotomy for a brain tumor. Child's Nerv Syst 10, 505–508 (1994). https://doi.org/10.1007/BF00335072
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DOI: https://doi.org/10.1007/BF00335072