Summary
4-carboxybenzaldehyde as well as 3- and 4-hydroxybenzaldehyde can form adducts with dextran or its derivatives. Few easy reaction steps are necessary and even if moderate yields of aldehyde are obtained, the aldehydic dextrans thus prepared are suitable for use as drug carrying systems.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Abbreviations
- Dx-OH:
-
dextran
- Dx-CHP:
-
chlorohydroxypropyl dextran
- Dx-NHP:
-
aminohydroxypropyl dextran
- 4-CBA:
-
4-carboxybenzaldehyde
- 3-HBA:
-
3-hydroxybenzaldehyde
- 4-HBA:
-
4-hydroxybenzaldehyde
- EDCI:
-
1-ethyl-3-(3-dimethyl-aminopropyl) carbodiimide hydrochloride
- glu:
-
glucose unit
References
E.P. GOLDBERG, in “Polymeric Drugs”, ed. by L.G. DONARUMA, O. VOGL, Academic Press New York, 239 (1978)
H. SEZAKI, M. HASHIDA, in “CRC Crit. Rev. Ther. Drug Carrier Systems, 1, 1 (1984)
N. IZUMIYA, M. MURAOKA, J. Am. Chem. Soc., 91, 2391 (1969)
J.C. SHEEHAN, J.J. HLAVKA, J. Org. Chem., 21, 439 (1956)
R. AXEN, J. PORATH, S. ERNBACK, Nature, 214, 1302 (1967)
A. JEANES, C.A. WILHAM, J. Am. Chem. Soc., 72, 2655 (1950)
E. SCHACHT, L. RUYS, J. VERMEERSCH, J. Controlled Release, 1 33, (1984)
E. CALLANT, F. VANDOORNE, E. SCHACHT, Reactive Polymers 8, 129 (1988)
F. BONNEAUX, Ph D, University of Nancy I, France (1992).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dellacherie, E., Bonneaux, F. A new approach to aldehydic dextrans. Polymer Bulletin 31, 145–149 (1993). https://doi.org/10.1007/BF00329959
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00329959