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The effect of food or milk on the absorption kinetics of ofloxacin

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Summary

We have studied the effects of food or milk on the absorption of ofloxacin in 21 healthy male volunteers in a three-way crossover design.

Milk did not alter the rate or extent of absorption of ofloxacin or its elimination.

Food altered the onset and/or rate of absorption, but not the extent of absorption or the elimination rate.

Thus, food reduced peak ofloxacin concentrations (Cmax) by 20% compared with fasting conditions and the time to reach maximum concentration (tmax) was prolonged on average by 1 h. However, the extent of absorption and the half-life (t1/2) of ofloxacin were the same after each treatment.

These data indicate that food and milk have a clinically insignificant effect on ofloxacin absorption.

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Authors and Affiliations

  1. Antiinfective Pharmacology Research Unit, University of Rhode Island College of Pharmacy and Roger Williams Medical Center, 02908, Providence, RI, USA

    M. N. Dudley & C. R. Marchbanks

  2. The R. W. Johnson Pharmaceutical Research Institute at Ortho Pharmaceutical Corporation, Raritan, USA

    S. C. Flor & B. Beals

Authors
  1. M. N. Dudley
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  2. C. R. Marchbanks
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  3. S. C. Flor
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  4. B. Beals
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Dudley, M.N., Marchbanks, C.R., Flor, S.C. et al. The effect of food or milk on the absorption kinetics of ofloxacin. Eur J Clin Pharmacol 41, 569–571 (1991). https://doi.org/10.1007/BF00314986

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  • DOI: https://doi.org/10.1007/BF00314986

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