Skip to main content
SpringerLink
Log in

Dysembryoplastic neuroepithelial tumour of the cerebellum

  • Case Report
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

Abstract

A case of dysembryoplastic neuroepithelial tumour of the cerebellum occurring in a 28-year-old woman is presented. The lesion extended from the cortex of the inferior vermis upwards into the white matter. Histologically, it exhibited areas of microcystic cerebellar astrocytoma and glial regions with hamartomatous blood vessels as well as areas with oligodendrocyte-like cells (OLC) with a delicate, fibrillary stroma lying in a mucinous, often microcystic matrix. The OLC showed prominent rosette formation and immunohistochemical features suggesting neuronal, i.e. granule cell, differentiation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Burgoyne RD, Cambray-Deakin MA (1988) The cellular neurobiology of neuronal development: the cerebellar granule cell. Brain Res Rev 13:77–101

    Google Scholar 

  2. Cattoretti G, Becker MHG, Key G, Duchrow M, Schlüter C, Galle J, Gerdes J (1992) Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. J Pathol 168:357–363

    Google Scholar 

  3. Cattoretti G, Pileri S, Parravicini C, Becker MHG, Poggi S, Bifulco C, Key G, D'Amato L, Sabattini E, Feudale E, Reynolds F, Gerdes J, Rilke F (1993) Antigen unmasking on formalinfixed, paraffin-embedded tissue sections. J Pathol 171:83–98

    Google Scholar 

  4. Daumas-Duport C (1993) Dysembryoplastic neuroepithelial tumours. Brain Pathol 3:283–295

    Google Scholar 

  5. Daumas-Duport C, Scheithauer BW, Chodkiewicz J-P, Laws ER Jr, Vedrenne C (1988) Dysembryoplastic neuroepithelial tumor: a surgically curable tumor of young patients with intractabele partial seizures. Report of thirty-nine cases. Neurosurgery 23:545–556

    Google Scholar 

  6. Gao W-Q, Heintz N, Hatten ME (1991) Cerebellar granule cell neurogenesis is regulated by cell-cell interactions in vitro. Neuron 6:705–715

    Google Scholar 

  7. Gottschalk J, Korves M, Skotzek-Konrad B, Goebel S, Cervós-Navarro J (1993) Dysembryoplastic neuroepithelial micro-tumor in a 75-year-old patient with long-standing epilepsy. Clin Neuropathol 12:175–178

    Google Scholar 

  8. Hasegawa H, Bitoh S, Koshino K, Obashi J, Kobayashi Y (1991) Dysembryoplastic neuroepithelial tumor; a case report. Neurol Surg 19:553–557

    Google Scholar 

  9. Hirose T, Scheithauer BW, Lopes MBS, VandenBerg SR (1994) Dysembryoplastic neuroepithelial tumor (DNT): an immunohistochemical and ultrastructural study. J Neuropathol Exp Neurol 53:184–195

    Google Scholar 

  10. Honavar M, Ansari S, Janota I, Polkey CE (1991) Dysembryoplastic neuroepithelial tumour (abstract). Neuropathol Appl Neurobiol 17:242–243

    Google Scholar 

  11. Ketz E (1974) Brain tumours and epilepsy. Handb Clin Neurol 16:254–269

    Google Scholar 

  12. Kirkpatrick PJ, Honavar M, Janota I, Polkey CE (1993) Control of temporal lobe epilepsy following en bloc resection of low-grade tumors. J Neurosurg 78:19–25

    Google Scholar 

  13. Kirsch J, Zutra A, Littauer UZ (1990) Characterization and intracellular distribution of microtubule-associated protein 2 in differentiating human neuroblastoma cells. J Neurochem 55: 1031–1041

    Google Scholar 

  14. Kleihues P, Burger PC, Scheithauer BW (1993) Histological typing of tumours of the central nervous system. World Health Organization: International histological classification of tumours, 2nd edn. Springer-Verlag, Berlin Heidelberg New York Tokyo

    Google Scholar 

  15. Koeller KK, Dillon WP (1992) Dysembryoplastic-neuroepithelial tumors: MR appearance. AJNR 13:1319–1325

    Google Scholar 

  16. Kuchelmeister K, Bergmann M (1992) Colloid cysts of the third ventricle: an immunohistochemical study. Histopathology 21:35–42

    Google Scholar 

  17. Leung SY, Gwi E, Ng HK, Fung CF, Yam KY (1994) Dysembryoplastic neuroepithelial tumor. A tumor with small neuronal cells resembling oligodendroglioma. Am J Surg Pathol 18: 604–614

    Google Scholar 

  18. Plate KH, Wieser H-G, Yasargil MG, Wiestler OD (1993) Neuropathological findings in 224 patients with temporal lobe epilepsy. Acta Neuropathol 86:433–438

    Google Scholar 

  19. Prayson RA, Estes ML (1992) Dysembryoplastic neuroepithelial tumor. Am J Clin Pathol 97:398–401

    Google Scholar 

  20. Raymond AA, Halpin SFS, Alsanjari N, Cook MJ, Kitchen ND, Fish DR, Stevens JM, Harding BN, Scaravilli F, Kendall B, Shorvon SD, Neville BGR (1994) Dysembryoplastic neuroepithelial tumour. Features in 16 patients. Brain 117:461–475

    Google Scholar 

  21. Shi S-R, Key ME, Kalra KL (1991) Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J Histochem Cytochem 39:741–748

    Google Scholar 

  22. Swarz JR, del Cerro M (1977) Lack of evidence for glial cells originating from the external granular layer in mouse cerebellum. J Neurocytol 6:241–250

    Google Scholar 

  23. Thomas JO, Nijjar J, Turley H, Micklem K, Gatter KC (1991) NB84: a new monoclonal antibody for the recognition of neuroblastoma in routinely processed material. J Pathol 163:69–75

    Google Scholar 

  24. Water KB, Honavar M, Janota I (1994) Cell proliferation marker expression in dysembryoplastic neuroepithelial tumour (abstract). Neuropathol Appl Neurobiol 20:310

    Google Scholar 

  25. Wolf HK, Wiestler OD,(1993) Surgical pathology of chronic epileptic seizure disorders. Brain Pathol 3:371–380

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut für Neuropathologie der Universität, Domagkstrasse 19, D-48129, Münster, Germany

    K. Kuchelmeister, M. Bergmann & F. Gullotta

  2. Neurochirurgische Klinik, Krankenhaus Bethesda, Hainstrasse 35, D-42109, Wuppertal, Germany

    T. Demirel

  3. Klinikum Wuppertal, Institut für Pathologie, Heusnerstrasse 40, D-42283, Wuppertal, Germany

    E. Schlörer

Authors
  1. K. Kuchelmeister
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. Demirel
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. Schlörer
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Bergmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. F. Gullotta
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kuchelmeister, K., Demirel, T., Schlörer, E. et al. Dysembryoplastic neuroepithelial tumour of the cerebellum. Acta Neuropathol 89, 385–390 (1995). https://doi.org/10.1007/BF00309634

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00309634

Key words

Search

Navigation