Summary
The metabolism of biphenyl by Pseudomonas sp. NCIB 10643 is reported in detail; that of Nocardia sp. NCIB 10503 is briefly investigated. Both organisms dissimilate biphenyl by the same route via oxidation to 2,3-dihydroxybiphenyl, meta cleavage to a product identified as 2-hydroxy-6-oxo-phenylhexa-2,4-dienoate which is then cleaved to give benzoate. Benzoate is a deadend metabolite in the pseudomonad but in the nocardia is further catabolised to catechol and thence to cis, cis-muconate. The enzymes involved in the individual steps of the proposed pathway have been assayed. The proposed pathway differs from that previously suggested for Pseudomonas sp. NCIB 10643 but is the same as found in other pseudomonads. This is the first report of catabolism of biphenyl in an actinomycete.
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Smith, M.R., Ratledge, C. Catabolism of biphenyl by Pseudomonas sp. NCIB 10643 and Nocardia sp. NCIB 10503. Appl Microbiol Biotechnol 30, 395–401 (1989). https://doi.org/10.1007/BF00296630
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DOI: https://doi.org/10.1007/BF00296630