Skip to main content
SpringerLink
Log in

Chromosomal damage in epileptics on monotherapy with carbamazepine and diphenylhydantoin

  • Original Investigations
  • Published:
Human Genetics Aims and scope Submit manuscript

Summary

We analyzed the leukocyte chromosomes of 10 epileptic probands on monotherapy with carbamazepine (CP), of 14 epileptic probands on monotherapy with diphenylhydantoin (DPH) and of 20 clinically normal probands (controls, CO). In the CP and in the DPH group we found a significant elevation of exchange-type aberrations as compared to the CO group. In the CP group we found predominantly chromatid translocations, in the DPH group exclusively dicentric chromosomes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Annegers, J. F., Elveback, L. R., Hauser, W. A., Kurland, L. T.: Do anticonvulsants have a teratogenic effect? Arch. Neurol. 31, 364–373 (1974)

    PubMed  Google Scholar 

  • Bartsch, H. D.: Cytogenetic testing of antiepileptic drugs in human patients. Mutat. Res. 29, 279 (1975) (Abstr.)

    PubMed  Google Scholar 

  • Diehl, L. W., Herha, J.: Documentation in an out-patient clinic for epileptics. In: Epileptology, D. Janz (ed.), Proceedings of the 7th international symposium on epilepsy. Berlin (West), June 19.–21., 1975, pp. 288–295. Stuttgart: Thieme 1976

    Google Scholar 

  • Diehl, L. W., Müller-Oerlinghausen, B., Riedel, E.: The importance of individual pharmacokinetic data for treatment of epilepsy with carbamazepine. Int. J. clin. Pharmacol. 1976 (in press)

  • Dudin, G., Beek, B., Obe, G.: The human leukocyte test system. I. DNA synthesis and mitoses in PHA-stimulated 2-day cultures. Mutat. Res. 23, 279–281 (1974)

    PubMed  Google Scholar 

  • Faigle, J. W., Brechbühler, S., Feldmann, K. F.: Die Biotransformation von Carbamazepin (Tegretol). In: W. Birkmayer (ed.), Epileptic seizures, behavior, pain. Internationales Symposium, St. Moritz, January 6.–7., 1975. Bern: Huber 1976

    Google Scholar 

  • Große, K.-P., Schwanitz, G., Rott, H.-D., Wißmüller, H. F.: Chromosomenuntersuchungen bei Behandlung mit Anticonvulsiva. Humangenetik 16, 209–216 (1972)

    PubMed  Google Scholar 

  • Janz, D.: teratologische Wirkungen von Antiepileptika. In: H. Helmchen und L. Diehl (eds.), Antiepileptische Langzeitmedikation, Pharmakokinetik-Klinische Begleitwirkungen. Bibliotheca Psychiatrica, No. 151, pp. 86–98. Basel: Karger 1975

    Google Scholar 

  • Neubert, D., Helge, H., Röhnelt, M.: Zum Problem pränataler Schädigungen bei antiepileptischer Therapie. In: H. Helmchen und L. Diehl (eds.), Antiepileptische Langzeitmedikation, Pharmakokinetik-Klinische Begleitwirkungen. Bibliotheca Psychiatrica, No. 151, pp. 99–113. Basel: Karger 1975

    Google Scholar 

  • Obe, G., Beek, B.: The human leukocyte test system. VII. Further investigations concerning micronucleus-derived premature chromosome condensation. Humangenetik 30, 143–154 (1975)

    PubMed  Google Scholar 

  • Obe, G., Beek, B., Dudin, G.: The human leukocyte test system. V. DNA synthesis and mitoses in PHA-stimulated 3-day cultures. Humangenetik 28, 295–302 (1975a)

    PubMed  Google Scholar 

  • Obe, G., Beek, B., Slacik-Erben, R.: The use of the human leukocyte test system for the evaluation of potential mutagens. European Society of Toxicology, 17th Meeting, Montpellier, June 16–18, 1975. Excerpta Medica Intern. Congr. Series, 1976 (in press)

  • Obe, G., Beek, B., Vaidya, V. G.: The human leukocyte test system. III. Premature chromosome condensation from chemically and X-ray induced micronuclei. Mutat. Res. 27, 89–101 (1975b)

    PubMed  Google Scholar 

  • Obe, G., Herha, J.: Chromosomal damage in chronic alcohol users. Humangenetik 29, 191–200 (1975)

    PubMed  Google Scholar 

  • Petruch, F., Schüppel, R. V. A.: Einfluß antikonvulsiver Behandlung auf den Arzneimittelabbau beim Menschen. Induktion des hydroxylierenden Enzymsystems der Leber durch Diphenylhydantoin und Carbamazepin. In: H. Helmchen und L. Diehl (eds.), Antiepileptische Langzeitmedikation, Pharmakokinetik-Klinische Begleitwirkungen. Bibliotheca Psychiatrica, No. 151, pp. 76–81. Basel: Karger 1975

    Google Scholar 

  • Reynolds, E. H.: Chronic antiepileptic toxicity: a review. Epilepsia (Basel) 16, 319–352 (1975)

    Google Scholar 

  • Riedel, E.: Methoden des Nachweises von Antiepileptika. In: H. Helmchen und L. Diehl (eds.), Antiepileptische Langzeitmedikation, Pharmakokinetik-Klinische Begleitwirkungen. Bibliotheca Psychiatrica, No. 151, pp. 1–14. Basel: Karger 1975

    Google Scholar 

  • Svensmark, O., Kristensen, P.: Determination of diphenylhydantoin and phenobarbital in small amounts of serum. J. Lab. clin. Med. 61, 501–507 (1963)

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Psychiatrische Klinik, Freie Universität Berlin, Berlin

    J. Herha & G. Obe

  2. Institut für Genetik, Freie Universität Berlin, Berlin

    J. Herha & G. Obe

Authors
  1. J. Herha
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Obe
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Herha, J., Obe, G. Chromosomal damage in epileptics on monotherapy with carbamazepine and diphenylhydantoin. Hum Genet 34, 255–263 (1976). https://doi.org/10.1007/BF00295288

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00295288

Keywords

Search

Navigation