Summary
The effect of food on the bioavailability of 6-mercaptopurine (6-MP) has been investigated. Seven patients were studied on two separate occasions. On the first occasion 6-MP was administered p. o. after an overnight fast and on the second, 15 min after a standard breakfast. 6-MP concentrations were determined by high-performance liquid chromatography. Variable plasma drug levels were observed between individual subjects in the fasting state. The peak levels of 6-MP were lower and took longer to be achieved following administration after a standard breakfast than after an overnight fast. In two subjects levels were undetectable (<20 ng/ml). In view of these observations it is suggested that 6-MP should be administered before food if maximum blood levels are to be achieved.
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References
Bosanquet AG, Gilby ED (1984) Comparison of the fed and fasting states on the absorption of melphalan in multiple myeloma. Cancer Chemother Pharmacol 12: 183
Burton NK, Aherne GW, Marks V (1984) A novel method for the quantitation of 6-mercaptopurine in human plasma using high performance liquid chromatography with fluorescence detection. J Chromatogr 309: 409
George CF (1984) Food, drugs and bioavailability. Br Med J 289: 1093
Lennard L, Rees CA, Lilleyman JS, Maddocks JL (1983) Childhood leukaemia: a relationship between intracellular mercaptopurine metabolites and neutropenia. Br J Clin Pharmacol 16: 359
Pearson ADJ, Craft AW, Eastham EJ, Aherne GW, Littleton P, Pearson GL, Campbell AN (1985) Small intestinal transit time affects methotrexate absorption in children with acute lymphoblastic leukemia. Cancer Chemother Pharmacol 14: 21
Schouten TJ, De Abreu RA, De Bruyn CHMM, Van der Kleijn E, Oosterbaan MJM, Schretlen EDAM, De Vaan GAM (1984) 6 mercaptopurine: pharmacokinetics in animals and preliminary results in children. Adv Exp Med Biol 165: 367
Zimm S, Collins JM, Riccardi R, O'Neill D, Narang PK, Chabner B, Poplack DG (1983) Variable bioavailability of oral mercaptopurine. Is maintenance chemotherapy in acute lymphoblastic leukemia being optimally delivered? N Engl J Med 308: 1005
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The authors thank the Leukaemia Research Fund and the Imperial Cancer Research Fund for their support
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Burton, N.K., Barnett, M.J., Aherne, G.W. et al. The effect of food on the oral administration of 6-mercaptopurine. Cancer Chemother. Pharmacol. 18, 90–91 (1986). https://doi.org/10.1007/BF00253074
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DOI: https://doi.org/10.1007/BF00253074