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Specialized subregions in the cat motor cortex: A single unit analysis in the behaving animal

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Summary

  1. (1)

    Participation of the motor cortex in initiating muscle contraction in an isometric tracking task was assessed in cats trained to make accurate force adjustments using forelimb muscles, in response to a vibrissal/visual display stimulus. Behavior in the task was characterized by short reaction times. While the task was performed, recordings of single cortical units were made in zones within area 4γ defined by the effects of microstimulation in forelimb muscles and by receptive fields on the forelimb.

  2. (2)

    Two types of receptive fields with different regional distributions were observed. Cells with simple receptive fields (superficial or deep) were seen throughout the area sampled, consisting of the lateral half of the anterior and posterior sigmoid gyri. Cells whose receptive fields had complex features (directional specificity, temporal lability, multiple foci, etc.) were preferentially located in the cortex rostral to the cruciate sulcus.

  3. (3)

    The area of motor cortex rostral to the cruciate sulcus also differed from the area caudal to the cruciate sulcus in the timing of task-related activity. Neurons that were active before response onset (lead cells), and could therefore contribute to response initiation, were preferentially located in the rostral cortex, and, in general, had complex receptive fields.

  4. (4)

    Lead cells were active at a constant latency from the stimulus, rather than being timed to response onset. However, the modulation of their activity was related to both the direction and magnitude of the force response.

  5. (5)

    These results suggest that the pericruciate motor cortex of the cat contains two functional subdivisions: a caudal one concerned with ongoing movement, perhaps under the control of specific sensory inputs from the responding limb, and a rostral one involved in initiating movement. Because behaviorally relevant stimuli can rapidly activate a specialized population of cells in the rostral cortex, this area is able to participate in responses with short reaction times.

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References

  • Adkins RJ, Cegnar MR, Rafuse DD (1971) Differential effects of lesions of the anterior and posterior sigmoid gyri in cats. Brain Res 30: 411–414

    Google Scholar 

  • Alstermark B, Lundberg A, Norrsell U, Sybirska E (1981) Integration in descending motor pathways controlling the forelimb in the cat. 9. Differential behavioral defects after spinal cord lesions interrupting defined pathways from higher centers to motorneurons. Exp Brain Res 42: 299–318

    CAS  PubMed  Google Scholar 

  • Anderson P, Hagan PJ, Phillips CG, Powell TPS (1975) Mapping by microstimulation of overlapping projections from area 4 to motor units of the baboon's hand. Proc R Soc Lond B 188: 31–60

    Google Scholar 

  • Asanuma H (1975) Recent developments in the study of the columnar arrangement of neurons within the motor cortex. Physiol Rev 55: 143–156

    Google Scholar 

  • Asanuma H (1981) The pyramidal tract. In: Brooks VB (ed) Handbook of physiology, sect I: the nervous system, vol II. Motor control. American Physiological Society, Bethesda, pp 703–733

    Google Scholar 

  • Asanuma H, Stoney SD Jr, Abzug C (1968) Relationship between afferent input and motor outflow in cat motorsensory cortex. J Neurophysiol 31: 670–681

    Google Scholar 

  • Baker MA, Tyner CF, Towe AL (1971) Observations on single neurons recorded in the sigmoid gyri of awake, non-paralyzed cats. Exp Neurol 32: 388–403

    Google Scholar 

  • Benita M, Conde H, Dormont JF, Schmied A (1979) Effects of ventrolateral thalamic nucleus cooling on initiation of forelimb ballistic flexion movements by conditioned cats. Exp Brain Res 34: 435–452

    Google Scholar 

  • Brooks VB (1979) Control of intended limb movements by the lateral and intermediate cerebellum. In: Asanuma H, Wilson VJ (eds) Integration in the Nervous System. Igaku-Shoin, Tokyo, pp 321–357

    Google Scholar 

  • Brooks VB, Kozlovskaya IB, Atkin A, Horvath FE, Uno M (1973) Effects of cooling the dentate nucleus on tracking-task performance in monkeys. J Neurophysiol 36: 974–995

    Google Scholar 

  • Brooks VB, Levitt H (1964) Excitability of neurons in sigmoid gyri. Physiologist 7: 3

    Google Scholar 

  • Brooks VB, Rudomin P, Slayman CL (1961a) Sensory activation of neurons in the cat's cerebral cortex. J Neurophysiol 24: 286–301

    Google Scholar 

  • Brooks VB, Rudomin P, Slayman CL (1961b) Peripheral receptive fields of neurons in the cat's cerebral cortex. J Neurophysiol 24: 302–325

    Google Scholar 

  • Buser P, Imbert M (1961) Sensory projections to the motor cortex in cats: a microelectrode study. In Rosenbluth WA (ed) Sensory communications. MIT Press, Cambridge, MA, pp 607–626

    Google Scholar 

  • Bushnell MC, Goldberg ME, Robinson DL (1981) Behavioral enhancement of visual responses in monkey cerebral cortex. I. Modulation in posterior parietal cortex related to selective visual attention. J Neurophysiol 46: 755–772

    Google Scholar 

  • Cheney PD, Fetz EE (1980) Functional classes of primate corticomotoneuronal cells and their relation to active force. J Neurophysiol 44: 773–791

    Google Scholar 

  • Conrad B, Wiesendanger M, Matsunami K, Brooks VP (1977) Precentral unit activity related to control of arm movements. Exp Brain Res 29: 85–95

    Google Scholar 

  • Dykes RW, Rasmusson DD, Hoeltzell PB (1980) Organization of primary somatosensory cortex in the cat. J Neurophysiol 43: 1527–1546

    Google Scholar 

  • Evarts E (1981) Role of motor cortex in voluntary movement in primates. In: Brooks VB (ed) Handbook of physiology, sect I: the nervous system, vol II. Motor control. American Physiological Society, Bethesda, pp 1083–1120

    Google Scholar 

  • Evarts EV (1966) Pyramidal tract activity associated with a conditioned hand movement in the monkey. J Neurophysiol 29: 1011–1027

    Google Scholar 

  • Evarts EV (1968) Relation of pyramidal tract activity to force exerted during voluntary movement. J Neurophysiol 31: 14–27

    Google Scholar 

  • Ghez C (1979) Contributions of central programs to rapid limb movement in the cat. In: Asanuma H, Wilson VJ (eds) Integration in the nervous system, Igaku-Shoin, Tokyo, pp 305–320

    Google Scholar 

  • Ghez C, Martin J (1982) The control of rapid limb movement in the cat. III. Agonist-antagonist coupling. Exp Brain Res 45: 115–125

    Google Scholar 

  • Ghez C, Vicario D (1978a) The control of rapid limb movement in the cat. I. Response latency. Exp Brain Res 33: 173–190

    Google Scholar 

  • Ghez C, Vicario D (1978b) The control of rapid limb movement in the cat. II. Scaling of isometric force adjustments. Exp Brain Res 33: 191–203

    Google Scholar 

  • Ghez C, Vicario D, Martin JH, Yumiya H (1982) Role of the motor cortex in the initiation of voluntary motor responses in the cat. Kyoto Symposia (EEG Suppl 36) pp 409–414

  • Ghez C, Vicario D, Martin J, Yumiya H (1983) Sensory-motor processing of targeted movements in motor cortex. In: Desmedt JE (ed) Motor control in health and disease. Raven Press, New York (in press)

    Google Scholar 

  • Goldberg ME, Bushnell MC (1981) Behavioral enhancement of visual responses in monkey cerebral cortex. II. Modulation in frontal eye fields specifically related to saccades. J Neurophysiol 46: 773–787

    Google Scholar 

  • Groos WP, Ewing LK, Carter CM, Coulter JD (1978) Organization of corticospinal neurons in the cat. Brain Res 143: 393–419

    Google Scholar 

  • Hassler R, Muhs-Clement K (1964) Architektonischer Aufbau des sensomotorischen und parietalen Cortex der Katze. J Hirnforsch 6: 377–422

    Google Scholar 

  • Jennings VA, Lamour Y, Solis H (1980) Premotor neurons in the postarcuate cortex of the monkey. Soc Neurosci Abstr. 6: 157

    Google Scholar 

  • Kwan HC, MacKay WA, Murphy JT, Wong YC (1978) Spatial organization of precentral cortex in awake primates. II. Motor outputs. J Neurophysiol 41: 1120–1131

    Google Scholar 

  • Kwan HC, Mackay WA, Murphy JT, Wong YC (1981) Distribution of responses to visual cues for movement in precentral cortex of awake primates. Neurosci Lett 24: 123–128

    Google Scholar 

  • Lamour Y, Jennings VA, Solis H (1980) Functional characteristics and segregation of cutaneous neurons in precentral motor cortex (MI). Soc Neurosci Abstr 6: 158

    Google Scholar 

  • Lamarre Y, Spidalieri G, Bushy L, Lund JP (1980) Programming of initiation and execution of ballistic arm movements in the monkey. Prog Brain Res 54: 157–169

    Google Scholar 

  • Lamarre Y, Bioulac B, Jacks B (1978). Activity of precentral neurons in conscious monkeys: Effects of deafferentation and cerebellar ablation. J Physiol (Paris) 74: 253–264

    Google Scholar 

  • Lemon RN, Porter R (1976) Afferent input to movement-related precentral neurones in conscious monkeys. Proc R Soc Lond B 194: 313–339

    Google Scholar 

  • Lundberg A (1979) Integration in a propriospinal motor center controlling the forelimb in the cat. In: Asanuma H, Wilson VJ (eds) Integration in the nervous system. Igaku-Shoin, Tokyo, pp 47–64

    Google Scholar 

  • Martin J, Yumiya H, Ghez C (1981) Coding of target and response variables in cat motor cortex. Soc Neurosci Abst 7: 562

    Google Scholar 

  • Matsumura M (1979) Intracellular synaptic potentials of primate motor cortex neurons during voluntary movement. Brain Res 163: 33–48

    Google Scholar 

  • Meyer-Lohmann J, Hore J, Brooks VB (1977) Cerebellar participation in generation of prompt arm movements. J Neurophysiol 38: 871–908

    Google Scholar 

  • Nieoullon A, Rispal-Padel L (1976) Somatotopic localization in cat motor cortex. Brain Res 105: 405–422

    Google Scholar 

  • Olsson KA, Landgren S (1980) Facilitation and inhibition of jaw reflexes evoked by electrical stimulation of the cat's cerebral cortex. Exp Brain Res 39: 149–164

    Google Scholar 

  • Pappas CL, Strick PL (1979) Double representation of the distal forelimb in motor cortex. Brain Res 167: 412–416

    Google Scholar 

  • Pappas CL, Strick PL (1981) Physiological demonstration of multiple representation in the forelimb region of cat motor cortex. J Comp Neurol 200: 481–490

    Google Scholar 

  • Phillips CG (1969) Motor apparatus of the baboon's hand. Proc R Soc Lond B 173: 141–174

    Google Scholar 

  • Porter R, Lewis M McD (1975) Relationship of neuronal discharges in the precentral gyrus of monkeys to the performance of arm movements. Brain Res 98: 21–36

    Google Scholar 

  • Robinson DL, Goldberg ME, Stanton GB (1978) Parietal association cortex in the primate: sensory mechanisms and behavioral modulations. J Neurophysiol 41: 910–932

    Google Scholar 

  • Schmied A, Benita M, Conde H, Dormont JF (1979) Activity of ventrolateral thalamic neurons in relation to a simple reaction time task in the cat. Exp Brain Res 36: 285–300

    Google Scholar 

  • Smith AM, Hepp-Reymond M-C, Wyss UR (1975) Relation of activity in precentral cortical neurons to force and rate of force change during isometric contractions of finger muscles. Exp Brain Res 23: 315–332

    Google Scholar 

  • Strick PL, Preston JB (1978a) Multiple representation in the primate motor cortex. Brain Res 154: 366–370

    Google Scholar 

  • Strick PL, Preston JB (1978b) Sorting of somatosensory afferent information in primate motor cortex. Brain Res 156: 364–368

    Google Scholar 

  • Tanji J, Kurata K (1982) Comparison of movement-related activity in two cortical motor areas of primates. J Neurophysiol 48: 633–653

    Google Scholar 

  • Tanji J, Wise SP (1981) Submodality distribution in sensorimotor cortex of the unanesthetized monkey. J Neurophysiol 45: 467–481

    Google Scholar 

  • Vicario D (1981) Discharge patterns of single neurons in cat motor cortex during performance of an isometric tracking task. (Ph. D. Thesis) Rockefeller University, New York

    Google Scholar 

  • Vicario D, Martin J, Ghez C (1980) Discharge of neurons in cat motor cortex during voluntary muscle contraction. Soc Neurosci Abstr 6: 125

    Google Scholar 

  • Weinrich M, Wise SP (1982) The pre-motor cortex of the monkey. J Neurosci 2: 1329–1345

    CAS  PubMed  Google Scholar 

  • Welt C, Aschoff JC, Kameda K, Brooks VB (1967) Intracortical organization of cat's motorsensory neurons. In: Yahr MD, Purpura DP (eds) Neurophysiological basis of normal and abnormal motor activities. Raven Press, New York, pp 255–293

    Google Scholar 

  • Yin TCT, Mountcastle VB (1977) Visual input to the visuomotor mechanism of the monkey's parietal lobe. Science 197: 1381–1383

    Google Scholar 

  • Yumiya H, Ghez C (1981) Topography of differential projections to rostral and caudal cat motor cortex. Soc Neurosci Abstr 7: 562

    Google Scholar 

  • Yumiya H, Ghez C (1983) Specialized subrogions in the cat motor cortex: anatomical demonstration of differential projections to rostral and caudal sectors. Exp Brain Res (in press)

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Supported by NIH grant NS 15750. Dr. Vicario received predoctoral support from an NIH training grant to Rockefeller University

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Vicario, D.S., Martin, J.H. & Ghez, C. Specialized subregions in the cat motor cortex: A single unit analysis in the behaving animal. Exp Brain Res 51, 351–367 (1983). https://doi.org/10.1007/BF00237872

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  • DOI: https://doi.org/10.1007/BF00237872

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