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Direct visualization of death of neurones projecting to specific targets in the developing rat brain

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Summary

The fluorescent dye diamidino yellow was injected into parts of the developing visual and auditory systems in the rat. The dye was retrogradely transported by projecting neurones and was found to stain pyknotic profiles within the labelled cell populations. It is thus possible to visualize directly the death of neurones which project axons to specific and identified target regions within the nervous system.

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Authors and Affiliations

  1. Department of Anatomy and Human Biology, The University of Western Australia, 6009, Nedlands, Perth, WA, Australia

    A. R. Harvey

  2. Department of Physiology, The University of Western Australia, 6009, Nedlands, Perth, WA, Australia

    D. Robertson & K. S. Cole

Authors
  1. A. R. Harvey
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  2. D. Robertson
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  3. K. S. Cole
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Harvey, A.R., Robertson, D. & Cole, K.S. Direct visualization of death of neurones projecting to specific targets in the developing rat brain. Exp Brain Res 80, 213–217 (1990). https://doi.org/10.1007/BF00228865

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  • DOI: https://doi.org/10.1007/BF00228865

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