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Antigenic analysis of the saccharide moiety of the lipooligosaccharide of Bordetella pertussis

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Conclusions

In summary, the LOS of B. pertussis lacks the long-chain polysaccharide O antigen, and is resolved electrophoretically into two distinct bands designated LOS A and LOS B. Mice administered with anti-LOS A mAbs can be protected from fatal B. pertussis infection. These observations may indicate potential for oligosaccharides as a component of new acellular pertussis vaccines. Studies performed thus far also suggest that idiotypic profiles influence the protective value of antibodies and that several antibody-mediated effector functions may participate in the protection. Further research investigating the factors inducing protective immunity is needed for a better definition of new vaccine formulations.

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Authors and Affiliations

  1. National Laboratory for Immunology, Laboratory Centre for Disease Control, H.P.B. Bldg. 7, K1A OL2, Tunney's Pasture, Ottawa, Canada

    Bernard R. Brodeur, Denis Martin, Josée Hamel & Craig Laferrière

  2. Center for Biologies Evaluation, FDA, 20892, Bethesda, MD, USA

    Roberta D. Shahin

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  1. Bernard R. Brodeur
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  2. Denis Martin
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  3. Josée Hamel
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  4. Roberta D. Shahin
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  5. Craig Laferrière
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Brodeur, B.R., Martin, D., Hamel, J. et al. Antigenic analysis of the saccharide moiety of the lipooligosaccharide of Bordetella pertussis . Springer Semin Immunopathol 15, 205–215 (1993). https://doi.org/10.1007/BF00201101

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