References
Bach BA, Sherman L, Benacerraf B, Greene MI (1978) Mechanisms of regulation of cell-mediated immunity. II. Induction and suppression of delayed type hypersensitivity to azobenzenearsonate-coupled syngeneic cells. J Immunol 121: 1460
Berendt MJ, North RJ (1980) T cell mediated suppression of anti-tumor immunity. An explanation for progressive growth of an immunogenic tumor. J Exp Med 151: 69
Berzofsky JA, Richman LK (1981) Genetic control of the immune response to myoglobins IV. Inhibition of determinant-specific Ir gene-controlled antigen presentation and induction of suppression by pretreatment of presenting cells with anti-Ia antibodies. J Immunol 126: 1989
Bhan AK, Perry LL, Cantor H, McCluskey RT, Benacerraf B, Greene MI (1981) The role of T cell sets in the rejection of a methylcholanthrene-induced sarcoma (S1509a) in syngeneic mice. Am J Pathol 102: 20
Bromberg JS, Carpenter CB, Greene MI (to be published) Genetics and mode of presentation of antigenic determinants: influence on immunologic responsiveness in transplantation. Hum Immunol
Burnet M (1970) Immunological surveillance. Pergamon Press, London
Cantor H, Shen FW, Boyse EA (1976) Separation of helper T cells from suppressor T cells expressing different Ly components. II. Activation by antigen: after immunization, antigen-specific suppressor and helper activities are mediated by distinct T cell subclasses. J Exp Med 143: 1391
Cooper GM, Okenquist S, Silverman L (1980) Transforming activity of DNA of chemically transformed and normal cells. Nature 284: 418
DeLeo AB, Shiku H, Takahashi T, John M, Old LJ (1977) Cell surface antigens of chemically induced sarcomas of the mouse. I. Murine leukemia virus-related antigens and alloantigens on cultured fibroblasts and sarcoma cells: description of a unique antigen on BALB/c meth A sarcoma. J Exp Med 146: 720
Dorf ME (1981) The role of the major histocompatibility complex in immunobiology. Garland Press, New York
Drebin JA, Perry LL, Bromberg JS, Nepom JT, Benacerraf B, Greene MI (1981) The effects of antisera directed at I-region gene products on syngeneic tumor immunity. In: Nydegger UE (ed) Immunochemotherapy. Academic Press, New York, p 99
Dye ES, North RJ (1981) T cell mediated immunosuppression as an obstacle to adoptive immunotherapy of the P815 mastocytoma, and its metastases. J Exp Med 154: 1033
Eckhart W, Hutchinson MA, Hunter T (1979) An activity phosphorylating tyrosine in polyoma T antigen immuno-precipitates. Cell 18: 925
Embleton MJ, Heidelberger C (1975) Neoantigens on chemically transformed cloned C34 mouse embryo cells. Cancer Res 35: 2049
Enker WE, Jacobitz JL (1980) In vivo splenic irradiation eradicates suppressor cells causing the regression and inhibition of established tumor. Int J Cancer 25: 819
Foley EJ (1953) Properties of methycholanthrene-induced tumor in mice of the strain of origin. Cancer Res 13: 835
Fox IJ, Perry LL, Sy M-S, Benacerraf B, Greene MI (1980) The influence of ultraviolet light irradiation on the immune system. Clin Immunol Immunopathol 16: 141
Fujimoto S, Greene MI, Sehon AH (1976) Regulation of the immune response to tumor antigens. I. Immuno-suppressor cells in tumor-bearing hosts. J Immunol 116: 791
Fujimoto S, Matsuzawa TT, Nakagawa K, Tada T (1978) Cellular interaction between cytotoxic and suppressor T cells against syngeneic tumors in the mouse. Cell Immunol 38: 378
Gorer PA (1937) The genetic and antigenic basis of tumor transplantation. J Pathol 44: 691
Green WF, Colley DG (1981) Modulation of Schistosoma mansoni egg-induced granuloma formation: I-J restriction of T cell-mediated suppression in a chronic parasitic infection. Proc Natl Acad Sci USA 78: 1152
Greenberg AH, Greene MI (1976) Non-adaptive rejection of small tumor inocula as a model of immune surveillance. Nature 264: 356
Greenberg PD, Cheever MA, Fefer A (1981) Eradication of disseminated murine leukemia by chemoimmunotherapy with cyclophosphamide and adoptively transferred immune syngeneic Lyt 1+2− lymphocytes. J Exp Med 154: 952
Greene MI, Fujimoto S, Sehon AH (1977) Regulation of the immune response to tumor antigens. III. Characterization of thymic suppressor factor(s) produced by tumor-bearing hosts. J Immunol 119: 757
Greene MI, Dorf ME, Pierres A, Benacerraf B (1977) Reduction of syngeneic tumor growth by an anti-I-J alloantiserum. Proc Natl Acad Sci USA 74: 5118
Greene MI, Pierres A, Dorf ME, Benacerraf B (1977) The I-J subregion codes for determinants on suppressor factor(s) which limit the contact sensitivity response to picryl chloride. J Exp Med 146: 293
Greene MI, Sugimoto M, Benacerraf B (1978) Mechanism of regulation of cell-mediated immune responses. I. Effect of the route of immunization with TNP-coupled syngeneic cells on the induction and suppression of contact sensitivity to picryl chloride. J Immunol 120: 1604
Greene MI, Sy M-S, Nisonoff A, Benacerraf B (1980) The genetic and cellular basis of antigen and receptor-stimulated regulation. Mol Immunol 17: 857
Greene MI, Sy M-S, Kripke M, Benacerraf B (1979) Impairment of antigen-presenting cell function by ultraviolet radiation. Proc Natl Acad Sci USA 76: 6591
Greene MI, Perry LL, Kinney-Thomas E, Benjamin TL (to be published) Specific thymus derived (T) cell recognition of papova virus transformed cells. J Immunol 128
Greene MI, Nellis MJ, Sy M-S, Nisonoff A (to be published) Regulation of immunity to the azobenzenearsonate hapten. Adv Immunol 32
Hellstrom I, Hellstrom KE, Evans CA, Heppner GH, Pierce GE, Yang JPS (1969) Serum-mediated protection of neoplastic cells from inhibition by lymphocytes immune to their tumor-specific antigens. Proc Natl Acad Sci USA 62: 362
Hellström KE, Hellström I (1971) Immunological defenses against cancer. In: Good RA, Fisher DW (eds) Immunobiology. Sinauer, Sunderland, p 209
Hellström KE, Hellström I, Nepom JT (1977) Specific blocking factors — are they important? Acta Biochem Biophys 473: 121
Hellström I, Hellström KE (1978) Cyclophosphamide delays 3-methylcholanthrene sarcoma induction in mice. Nature 275: 129
Hellström KE, Hellström I, Kant JA, Tamerius JD (1978) Regression and inhibition of sarcoma growth by interference with a radiosensitive T-cell population. J Exp Med 148: 799
Hutchinson MA, Hunter T, Eckhart W (1978) Characterization of T antigens in polyoma infected and transformed cells. Cell 15: 65
Invernizzi G, Parmiani G (1975) Tumor-associated transplantation antigens of chemically induced sarcomas cross-reacting with allogeneic histocompatibility antigens, Nature 254: 713
Ito Y (1980) Organization and expression of genome of polyoma virus. In: Klein G (ed) Viral oncology. Raven Press, New York, p 447
Kanno M, Kobayashi S, Takuhisa T, Takei I, Shinohara N, Taniguchi M (1981) Monoclonal antibodies that recognize the product controlled by a gene in the I-J sub-region of the mouse H-2 complex. J Exp Med 154: 1290
Kiselow P, Hurst JA, Shiku H, Beverly PCL, Hoffman MK, Boyse EA, Oettgan HF (1975) Ly antigens as markers of functionally distinct subpopulations of thymus-derived lymphocytes of the mouse. Nature 153: 219
Klein, G., Sjögren MD, Klein E, Hellström KE (1960) Demonstration of resistance against methycholanthrene-induced sarcomas in the primary autochthonous host. Cancer Res 20: 1561
Klein G (1980) Tumor immunology. In: Fourgereau M, Dausset J (eds) Immunology 80. Academic Press New York, p 680
Kripke ML, Fisher MS (1976) Immunologic parameters of ultraviolet carcinogenesis. J Natl Cancer Inst 57: 211
Kuettner MG, Wang AL Nisonoff A (1972) Quantitative investigations of idiotypic antibodies. VI. Idiotypic specificity as a potential genetic marker for the variable regions of mouse immunoglobulin polypeptide chains. J Exp Med 135: 579
Landsteiner K (1945) The specificity of serological reactions. Harvard University Press, Cambridge
Langan T (1980) Malignant transformation and protein phosphorylation. Nature 286: 329
Loveland BE, Hogarth PM, Ceredig RH, McKenzie IFC (1981) Cells mediating graft rejection in the mouse I. Lyt-1 cells mediate skin graft rejection. J Exp Med 153: 1044
Meruelo D, Flieger N, Smith D, McDevitt HO (1980) In vivo or in vitro treatments with anti I-J alloantiserum abolish immunity to AKR leukemia. Proc Natl Acad Sci USA 77: 2178
Minami A, Kasai M, Mizushima Y, Takeichi N, Hosokawa M, Kobayashi H (1980) Characterization of immunosuppressor cells in rats immunized with solubilized tumor-associated antigens prepared from a methylcholanthrene-induced fibrosarcoma. Cancer Res 40: 2129
Minami M, Okuda K, Shuchi F, Benacerraf B, Dorf ME (1981) Analysis of T cell hybridomas I. Characterization of H-2 and Igh-restricted monoclonal suppressor factors. J Exp Med 154: 1390
Mitchison NA, Kinlen LJ (1980) Present concepts in immune surveillance. In: Fougerau M, Dausset J (eds) Immunology 80. Academic Press, New York, p. 641
Murphy DB, Herzenberg LA, Okumura K, Herzenberg LA, McDevitt HO (1976) A new I subregion (I-J) marked by a locus (Ia4) controlling surface determinants on suppressor T lymphocytes. J Exp Med 144: 699
Naor D (1979) Suppressor cells: permitters and promoters of malignancy. Adv Cancer Res 29: 35
Nepom, JT, Benacerraf B, Germain RN (1981) Analysis of Ir gene function using monoclonal antibodies: independent regulation of GAT and GLPhe T cell responses by I-A and I-E subregion products on a single accessory cell population. J Immunol 127: 31
Nepom JT, Benacerraf B, Germain RN (1981) Acquisition of syngeneic I-A determinants by T cells proliferating in response to poly(Glu60Ala30Tyr10). J Immunol 127: 888
Nisonoff A, Greene MI (1980) Regulation through idiotypic determinants of the immune response to the p-azobenzenearsonate hapten in strain A mice. In: Fourgerau M, Dausset J (ed) Immunology 80. Academic Press, New York, p 57
Old, LJ, Boyse EA, Clarke DA, Carswell E (1962) Antigenic properties of chemically induced tumors. Ann NY Acad Sci 101: 80
Old LJ (1981) Cancer immunology: the search for specificity. Cancer Res 41: 361
Perry LL, Benacerraf B, Greene MI (1978) Regulation of the immune response to tumor antigens IV. Tumor antigen-specific factor(s) bear I-J determinants and induce suppressor T cells in vivo. J Immunol 121: 2144
Perry LL, Benacerraf B, McCluskey R, Greene MI (1978) Enhanced syngeneic tumor destruction by in vivo inhibition of suppressor T cells using anti-I-J alloantisera. Am J. Pathol 92: 491
Perry LL, Dorf ME, Benacerraf B, Greene MI (1978) Regulation of immune response to tumor antigen: interference with syngeneic tumor immunity by anti I-A alloantisera. Proc Natl Acad Sci 76: 920 USA
Perry LL, Dorf ME, Bach BA Benacerraf B, Greene MI (1980) Mechanisms of regulation of cell-mediated immunity: anti I-A alloantisera interfere with induction and expression of T cell-mediated immunity to cell-bound antigen in vivo. Clin Immunol Immunpathol 15: 279
Perry LL, Kripke ML, Benacerraf B, Dorf ME, Greene MI (1980) Regulation of the immune response to tumor antigen. VIII. The effects of host-specific anti-J-J antibodies on the immune response to tumors of different origin. Cell Immunol 51: 349
Perry LL, Greene MI (1981) T cell subset interaction in the regulation of syngeneic tumor immunity. Fed Proc 40: 39
Pierres M, Germain RN, Dorf ME, Benacerraf B (1978) In vivo effects of anti-Ia alloantisera. I. Elimination of specific suppression by in vivo administration of antisera specific for I-J controlled determinants. J Exp Med 147: 656
Prehn RT, Main JM (1957) Immunity to methylcholanthrene-induced sarcomas. J Natl Cancer Inst 18 769
Reinisch CJ, Andrew SL, Schlossman SF (1977) Suppressor cell regulation of tumor immunity: abrogation by adult thymectomy. Proc Natl Acad Sci USA 74: 2989
Rosenbaum JT, Adelman NE, McDevitt HO (1981) In vivo effects of antibodies to immune response gene products. I. Haplotype-specific suppression of humoral immune responses with a monoclonal anti I-A. J Exp Med 154: 1694
Rosenberg SA, Terry WD (1977) Passive immunotherapy of cancer in animals and man. Adv Cancer Res 25: 323
Rosenthal AS, Shevach EN (1973) Function of macrophagus in antigen recognition by guinea pig T lymphocytes I. Requirement for histocompatible macrophages and lymphocytes. J Exp Med 138: 1194
Shiku H, Takahashi T, Beam MA, Old LJ, Oettgen HF (1976) Ly phenotype of cytotoxic T cells for syngeneic tumor. J Exp Med 144: 1116
Shih C, Shilo B-Z, Goldfarb MP, Dannenberg A, Weinberg RA (1979) Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin. Proc Natl Acad Sci USA 76: 5714
Shimuzu K, Shen RW (1979) Role of different T cell sets in the rejection of syngeneic chemically induced tumors. J Immunol 122: 1162
Silver J, Schaffhausen B, Benjamin T (1978) Tumor antigens induced by nontransforming mutants of polyoma virus. Cell 15: 485
Spellman CW, Daynes RA (1978) Ultraviolet light induced murine suppressor lymphocytes dictate specificity of anti-ultraviolet light tumor immune responses. Cell Immunol 38: 25
Sprent J (1980) Effects of blocking helper T cell induction in vivo with anti-Ia antibodies. Possible role of I-A/E hybrid molecules as restriction elements. J Exp Med 152: 996
Sprent J, Lerner EA, Bruce J, Symington FW (1981) Inhibition of T cell activation in vivo and with mixtures of monoclonal antibodies specific for I-A and I-A/E molecules. J Exp Med 154: 188
Steinman L, Rosenbaum JT, Sriran S, McDevitt HO (1981) In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalitis. Proc Natl Acad Sci USA 78: 7111
Sy M-S, Miller SD, Moorhead JW, Claman HN (1979) Active suppression of 1-fluoro-2,4, dinitrobenzene-immune T cells. Requirement of an auxillary T cell induced by antigen. J Exp Med 149: 1197
Sy M-S, Dietz MH, Nisonoff A, Germain RN, Benacerraf B, Greene MI (1980) Antigen and receptor-driven relatory mechanisms. V. The failure of idiotype-coupled spleen cells to induce unresponsiveness in animals lacking the appropriate VH gene is due to the lack of idiotype-matched targets. J Exp Med 152: 1226
Sy M-S, Dietz MH, Germain RN, Benacerraf B, Greene MI (1980) Antigen and receptor-driven regulatory mechanisms. IV. Idiotype-bearing I-J+ suppressor T cell factors induce second order suppressor cells which express anti-idiotype receptors. J Exp Med 151: 1183
Sy M-S, Nisonoff A, Germain RN, Benacerraf B, Greene MI (1981) Antigen and receptor driven regulatory mechanisms. VIII. Suppression of idiotype-negative, p-azobenzenearsomate-specific T cells results from the interaction of an anti-idiotypic second-order T suppressor cell with a cross-reactive idiotype positive, p-azobenzenearsonate primed T cell target. J Exp Med 153: 1415
Stutman O (1975) Tumor development after polyoma infection in athymic nude mice. J Immunol 114: 1213
Tada T, Taniguchi M, David CS (1976) Properties of the antigen-specific suppressive T-cell factor in the regulation of antibody response in the mouse. IV. Special subregion assignment of the gene(s) that codes for suppressive T cell factor in the H-2 complex. J Exp Med 144: 713
Tevethia SS, Flyer DC, Tjian R (1980) Biology of simian virus 40 (SV40) transplantation antigen (Tr Ag). VI. Mechanisms of induction of SV40 transplantation immunity in mice by purified SV40 T antigen (D2 protein). Virology 107: 13
Tilken AF, Schaaf-Lafontaine N, Van Acker A, Boccadoro M, Urbain J (1981) Reduced tumor growth after low-dose irradiation or immunization against blastic suppressor T cells. Proc Natl Acad Sci USA 78: 1809
Treisman R, Novak U, Favaloro J, Kamen R (1981) Transformation of rat cells by an altered polyoma virus genome expressing on the middle T protein. Nature 292: 595
Waltenbaugh C (1981) Regulation of immune response by I-J gene products. I. Production and characterization of anti-I-J monoclonal antibodies. J Exp Med 154: 1570
Weinberger JZ, Germain RN, Ju ST, Greene MI, Benacerraf B, Dorf ME (1979) Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. II. Demonstration of idiotypic determinants on suppressor T cells. J Exp Med 150: 761
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Supported by grant AI 16396-03 from the NIH and grant IM-277 from the American Cancer Society
Supported by Immunology Training Grant CA09141 in conjunction with the M.D. — Ph.D. Program at Harvard Medical School
Abbreviations used in this paper: ABA p-Azobenzenearsonate; ADCC Antibody-dependent cell-mediated cytotoxicity cell; APC Antigen-presenting cell; cDNA Complementary DNA sequence; CRI Cross-reactive idiotype; CTL Cytolytic thymus-derived lymphocyte; HLA Human leukocyte antigen gene complex; IV Intravenous; KLH Keyhole limpet hemocyanin; mRNA Messenger ribonucleic acid; NK Natural killer cell; NP 4-Hydroxy-3-nitrophenyl acetyl; T Thymus derived; Ts Suppressor T cell; Ts1 First order suppressor T cell; Ts2 Second order to suppressor T cell; Ts3Third order suppressor T cell; TsF1 First order suppressor T cell factor, produced by Ts1; TsF2 Second order suppressor T cell factor, produced by Ts2; UV Ultraviolet; V HHeavy chain variable region; V L Light chain variable region
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Drebin, J.A., Perry, L.L., Carter, R. et al. Regulation of the immune response to antigens on the malignant cell surface. Springer Semin Immunopathol 5, 175–192 (1982). https://doi.org/10.1007/BF00199795
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DOI: https://doi.org/10.1007/BF00199795