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Cyclosporine pharmacokinetics in nephrotic and kidney-transplanted children

  • Pharmacokinetics and Disposition
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Abstract

The pharmacokinetic parameters of cyclosporine (CsA) were determined in 23 kidney transplant recipients and 19 children with nephrotic syndrome, after intravenous and oral administration.

The mean bioavailability was 39 %, blood clearance was 0.55 l · h-1 · kg-1 and volume of distribution at steady-stade was 2.77 l · kg-1. The absorption profile was monophasic (67 %), biphasic (29 %) or poor (4 %). The maximum blood concentration of CsA was significantly higher in children with a monophasic profile than in children with a biphasic profile (550 vs 380 ng · ml-1). Blood clearance was significantly higher in the transplant recipients than in the patients with nephrotic syndrome (0.65 vs 0.43 l · h-1 · kg-1.

Although age, haematocrit, creatinine clearance, serum albumin and cholesterol differed between the two groups, only haematocrit and creatinine clearance were significantly (negatively) correlated with CsA clearance.

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Authors and Affiliations

  1. Department of Clinical Pharmacology, Hôpital Robert Debré, 48 Boulevard Sérurier, F-75019, Paris, France

    E. Jacqz-Aigrain & C. Montes

  2. Department of Nephrology, Hôpital Robert Debré, 48 Boulevard Sérurier, F-75019, Paris, France

    P. Brun & C. Loirat

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  1. E. Jacqz-Aigrain
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  2. C. Montes
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  3. P. Brun
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  4. C. Loirat
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Jacqz-Aigrain, E., Montes, C., Brun, P. et al. Cyclosporine pharmacokinetics in nephrotic and kidney-transplanted children. Eur J Clin Pharmacol 47, 61–65 (1994). https://doi.org/10.1007/BF00193480

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  • DOI: https://doi.org/10.1007/BF00193480

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