Summary
Atopic dry skin characterized by a defect of the barrier function as determined by trans-epidermal water-loss measurements at the ultrastructural level shows an increase in membranecoating granules (MCGs). MCGs are lamellar, ovoid organelles appearing in the stratum spinosum and stratum granulosum. MCGs consist of stacks of small parallel disks that are extruded and fuse to continuous lamellae. Liposomes, i.e., unior multilamellar vesicles composed of alternating lipid and water phases are structurally similar. Moreover, they also can form continuous lamellae. While phospholipids are generally used for liposome production, skin lipids and in particular ceramides can also be used. These lipids also seem to be the major components of MCGs. Hence, it seems advisable to use liposomes made of such lipids in the treatment of atopic dry skin. Apart from the probable inherent effect liposomes of this type may also apply particularly well for the delivery of active components.
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Abbreviations
- MCG:
-
membrane-coating granule
References
Abraham W (1992) Structures formed by epidermal lipids in vitro. Semin Dermatol 11:121–128
Abraham W, Downing DT (1989) Preparation of model membranes for skin permeability studies using stratum corneum lipids. J Invest Dermatol 93:809–813
Abraham W, Downing DT (1990) Interaction between corneocytes and stratum corneum lipid liposomes in vitro. Biochim Biophys Acta 1021:119–125
Abraham W, Wertz PW, Landmann L et al. (1987) Stratum corneum lipid liposomes: calcium-induced transformation into lamellar sheets. J Invest Dermatol 88:212–214
Bangham AD (1980) Development of the liposome concept. In: Gregoriadis G, Allison AC (eds) Liposomes in biological systems. Wiley, New York, pp 1–24
Bangham AD, Standish MM, Watkins JC (1965) Diffusion of univalent ions across the lamellae of swollen phospholipids. J Mol Biol 13:238–252
Bonnekoh B, Röding J, Krueger GRF et al. (1991) Increase of lipid fluidity and suppression of proliferation resulting from liposome uptake by human keratinocytes in vitro. Br J Dermatol 124:333–340
Chapman SJ, Walsh A, Jackson SM et al. (1991) Lipids, proteins and corneocyte adhesion. Arch Dermatol Res 283:167–173
Elias PM (1981) Lipids and epidermal permeability barrier. Arch Dermatol Res 270:95–117
Elias PM (1983) Epidermal lipids, barrier function and desquamation. J Invest Dermatol 80:44s–49s
Elias PM (1991) Epidermal barrier function: intercellular lamellar lipid structures, origin, composition and metabolism. J Controlled Release 15:199–208
Elias PM, Friend DS (1975) The permeability barrier in mammalian epidermis. J Cell Biol 65:180–191
Elias PM, Goerke J, Friend DS (1977) Permeability barrier lipids: composition and influence on epidermal structure. J Invest Dermatol 69:535–546
Elias PM, Brown BE, Fritsch PO et al. (1979) Localization and composition of lipids in neonatal mouse stratum granulosum and stratum corneum. J Invest Dermatol 73:339–348
Fartasch M, Bassukas ID, Diepgen TL (1992) Disturbed extruding mechanism of lamellar bodies in dry non-eczematous skin of atopics. Br J Dermatol 127:221–227
Gray GM, White RJ (1973) Epidermal lipid liposomes: a novel nonphospholipid membrane system. Biochem Soc Trans 7:1129–1131
Hashimoto K (1971) Cementosome, a new interpretation of the membrane-coating granule. Arch Dermatol Res 240:349–364
Imokawa G, Akasaki S, Minematsu J et al. (1989) Importance of intercellular lipids in water-retention properties of stratum corneum: induction and recovery study of surfactant dry skin. Arch Dermatol Res 281:45–51
Kerscher M, Korting HC, Schäfer-Korting M (1991) Skin ceramides: structures and function. Eur J Dermatol 1:39–43
Korting HC, Zienicke H, Schäfer-Korting M et al. (1990) Liposome encapsulation improve efficiency of betamethasone dipropionate in atopic eczema but not in psoriasis vulgaris. Eur J Clin Pharmacol 39:349–351
Author deleted
Landmann L (1984) The epidermal permeability barrier. Comparison between in vivo and in vitro lipid structures. Eur J Cell Biol 33:258–264
Landmann L (1986) Die Permeabilitätsbarriere der Haut. Schweiz Rundsch Med Prax 32:927–932
Landmann L (1988) The epidermal permeability barrier. Anat Embryol 178:1–19
Landmann L, Wertz PW, Downing DT (1984) Acylglucosylceramide causes flattening and stacking of liposomes: an analogy for assembly of the epidermal permeability barrier. Biochim Biophys Acta 778:412–418
Lavker RM (1976) Membrane-coating granules: the fate of the discharged lamellae. J Ultrastruct Res 55:79–86
Matoltsy AG (1966) Membrane-coating granules of the epidermis. J Ultrastruct Res 15:510–515
Matoltsy AG, Parakkal FF (1965) Membrane-coating granules of keratinizing epithelia. J Cell Biol 24:297–307
Odland GF (1960) A submicroscopic granular component in human epidermis. J Invest Dermatol 34:11–15
Selby CC (1957) An electron microscopic study of thin sections of human skin. Superficial cell layers of footpad epidermis. J Invest Dermatol 29:131–149
Silverman S, Kearns G (1970) Ultrastructural localization of acid phosphatase in human buccal epithelium. Arch Oral Biol 15:169–177
Weiner N, Williams N, Birch G (1989) Topical delivery of liposomally encapsulated interferon evaluated in a cutaneous herpes guinea pig model. Antimicrob Agents Chemother 33:1217–1221
Weinstock M, Wilgram GF (1970) Fine structural observations on the formation and enzymatic activity of keratinosomes in mouse filiform papillae. J Ultrastruct Res 300:262–274
Werner Y (1986) The water content of the stratum corneum in patients with atopic dermatitis. Measurements with the corneometer CM 420. Acta Derm Venereol (Stockh) 66:281–284
Werner Y, Lindberg M (1985) Transepidermal water loss in dry and clinically normal skin in patients with atopic dermatitis. Acta Derm Venereol (Stockh) 65:102–105
Werner Y, Lindberg M, Forslind B (1982) The water-binding capacity of stratum corneum in dry non-eczematous skin of atopic eczema. Acta Derm Venereol (Stockh) 62:334–337
Werner Y, Lindberg M, Forslind B (1987) Membrane-coating granules in “dry” non-eczematous skin of patients with atopic dermatitis. Acta Derm Venereol (Stockh) 67:385–390
Wertz PW, Downing DT (1982) Glycolipids in mammalian epidermis: structure and function in the water barrier. Science 217:1261–1262
Wertz PW, Downing DT, Freinkel RK et al. (1984) Sphingolipids of the stratum corneum and lamellar granules of fetal rat epidermis. J Invest Dermatol 83:193–195
Wertz PW, Abraham W, Landmann L et al. (1986) Preparation of liposomes from stratum corneum lipids. J Invest Dermatol 87:582–584
Wilgram GF (1965) Das Keratinosom: Ein Faktor im Verhornungsprozeß der Haut. Hautarzt 16:377–379
Wolff K, Schreiner E (1970) Epidermal lysosomes. Electron microscopic and electron microscopic-cytochemical studies. Arch Dermatol 101:276–286
Wolff-Schreiner EC (1977) Ultrastructural cytochemistry of the epidermis. Int J Dermatol 16:77–102
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Schmid, M.H., Korting, H.C. Liposomes for atopic dry skin: the rationale for a promising approach. Clin Investig 71, 649–653 (1993). https://doi.org/10.1007/BF00184495
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DOI: https://doi.org/10.1007/BF00184495