Abstract
The concentration of the metabolite of the beta-blocker metipranolol was determined in the aqueous humour of 89 cataract patients. At 1, 2 or 5 h before surgery, they received one drop (30 μl) of a 0.1 % or 0.3% solution of the drug. At 1, 2 or 5 h after the application of 0.1 % metipranolol eye drops, desacetylmetipranolol concentrations of 624.55, 235.29 and 88.02 ng/ ml, respectively, were measured. At the same intervals after the instillation of 0.3% metipranolol eye drops, the respective values of 1289.20, 1120.88 and 327.36 ng/ ml were found. The metabolite concentration in the eye drops and the values measured show no consistent correlation.
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Keβler, C., Bleckmann, H. & Kleintges, G. Influence of the concentration of metipranolol eye drops on the drug concentration in human aqueous humour. Graefe's Arch Clin Exp Ophthalmol 229, 487–491 (1991). https://doi.org/10.1007/BF00166315
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DOI: https://doi.org/10.1007/BF00166315