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Evidence for macrophage-mediated defluorization of a Teflon vascular graft

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Abstract

Polytetrafluoroethylene (PTFE) is a common biomaterial used for vascular grafts because it is regarded as a nondegradable material with good healing characteristics and a low complication rate, even as a long-term implant. XPS-investigation of a ruptured arterial PTFE-prosthesis with formation of a false aneurysm revealed loss of fluorine at the area of rupture, whereas fluorine was found in the morphologically intact areas in normal concentrations. Because macrophages, found in large number at the ruptured and degraded area, are capable of producing hydroperoxide radicals, it is assumed that the present case is an example of macrophage-mediated defluorization with subsequent rupture of the PTFE-prosthesis.

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References

  1. T. SOYER, M. LEMPINEN, P. COOPER, L. NORTON and B. EISEMAN, Surgery 72 (1972) 864.

    Google Scholar 

  2. H. MATSUMOTO, T. HASEGAWA, K. FUSE, M. VAMAMOTO, M. SAIGUSA, Surgery, 74 (1973) 519.

    Google Scholar 

  3. C. D. CAMPBELL, D. H. BROOKS, M. W. WEBSTER and H. T. BAHNSON, Surgery, 79 (1976) 485.

    Google Scholar 

  4. B. GUIDOIN, N. CHAKFE, S. MAUREL, T. HOW, M. BATT, M. MABOIS and C. GOSSELIN, Biomaterials 14 (1993) 678.

    Google Scholar 

  5. J. P. CAMILLERI, V. N. PHAT, P. BRUNEVEAL, V. TRICOTTET, A. BALATON, J. N. FIESINGER and J. M. CORMIER. Arch. Path. Lab. Med. 109 (1985) 833.

    Google Scholar 

  6. C. B. ANDERSON, G. E. ETHERIDGE and G. A. SICARD, Dial. Transpl. 47 (1980) 145.

    Google Scholar 

  7. M. J. FORMICHI, R. G. GUIDOIN, J. M. JAUSSERAN, J. A. AWAD, K. W. JOHNSTON, M. W. KING, R. COURBIER, M. MAROIS, C. ROULEAU, M. BATT, J. F. GIRARD and C. GOSSELIN. Ann. Vasc. Surg. 2 (1988) 14.

    Google Scholar 

  8. R. GUIDOIN, S. MAUREL, N. CHAKFE, T. HOW, Z. ZHANG, M. THERRIEN, M. FORMICHI and C. GOSSELIN, Biomaterials 14 (1993) 694.

    Google Scholar 

  9. C. F. NATHAN. J. Clin. Invest. 79 (1987) 319.

    Google Scholar 

  10. H. W. KAEBRUICK, B. F. BANDYK, T. W. BERGAMINI and J. B. TOWNE. Surgery 102 (1987) 756.

    Google Scholar 

  11. N. CHAKFE, R. GUIDOIN, M. MAROIS, P. E. ROY, Y. DOUVILLE, P. ROY, M. BATT, C. GOSSELIN. J. Biomater. Appl. 5 (1991) 227.

    Google Scholar 

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Authors and Affiliations

  1. Institute of Pathology, University of Technology, Pauwelsstr. 30, D-52057, Aachen, Germany

    S. Hauptmann, B. Klosterhalfen & C. Mittermayer

  2. Domhofklinik (Clinic of Angiology), Katschhof 3, D-52062, Aachen, Germany

    K. U. Rühlmann

  3. Macromolecular and Textile Chemistry, University of Technology, Veltmanplatz 8, D-52062, Aachen, Germany

    R. Kaufmann & H. Höcker

Authors
  1. S. Hauptmann
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  2. B. Klosterhalfen
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  3. C. Mittermayer
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  4. K. U. Rühlmann
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  5. R. Kaufmann
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  6. H. Höcker
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Hauptmann, S., Klosterhalfen, B., Mittermayer, C. et al. Evidence for macrophage-mediated defluorization of a Teflon vascular graft. J Mater Sci: Mater Med 7, 345–348 (1996). https://doi.org/10.1007/BF00154546

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  • DOI: https://doi.org/10.1007/BF00154546

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